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- W2903086599 abstract "Evidence is accumulating that Paget's disease of bone has a slow, viral cause. The clinical presentation is highly variable, depending on the skeletal location and phase of the disease. The most common symptoms are bone pain, deformities, or pathologic fracture. Arthritic symptoms of the hip or knee, or symptoms related to nerve compression by disease-enlarged bone also occur. Plain radiographs are often pathognomonic of Paget's disease; however, in atypical cases, biopsy may be necessary to rule out neoplastic disease. The most effective medications currently used for treatment are the calcitonins and biphosphonates. Mithramycin is reserved for Paget's paraplegia or recalcitrant cases. Fracture stabilization, corrective osteotomies, and joint arthroplasties have been highly successful when carefully planned and executed. In these cases, perioperative treatment with calcitonin is recommended." @default.
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- W2903086599 date "1990-03-01" @default.
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- W2903086599 title "Special Article" @default.
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- W2903086599 doi "https://doi.org/10.1016/s0889-8529(18)30343-8" @default.
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