FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903094977> ?p ?o ?g. }

• W2903094977 endingPage "340" @default.
• W2903094977 startingPage "330" @default.
• W2903094977 abstract "Second-generation basal insulin analogues (e.g. insulin degludec, insulin glargine 300 U/mL), were designed to further extend the duration of insulin action and reduce within-day and day-to-day variability, and consequently hypoglycaemia risk, versus earlier long-acting basal insulins. This review examines the pharmacokinetic/pharmacodynamic characteristics of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL), and their influence on clinical outcomes.Available pharmacokinetic/pharmacodynamic publications comparing insulin degludec and insulin glargine were reviewed.Both insulin degludec and insulin glargine 300 U/mL have more prolonged and stable pharmacokinetic/pharmacodynamic profiles than the earlier basal insulin analogue, insulin glargine 100 U/mL. Insulin glargine 300 U/mL (0.4 U/kg, morning) showed a more stable pharmacodynamic profile (20% lower within-day variability [P = 0.047]) and more even 24-h distribution (over each 6-h quartile) than insulin degludec 100 U/mL, whereas the supratherapeutic 0.6 U/kg dose demonstrated a similar, albeit non-significant, trend. In contrast, a second clamp study indicated lower day-to-day variability in the 24-h glucose-lowering effect (variance ratio 3.70, P < 0.0001), and more even dosing over each 6-h quartile, with insulin degludec 200 U/mL versus insulin glargine 300 U/mL (0.4 U/kg, evening). Methodological differences and differences in bioequivalence that may explain these discrepancies are discussed.Compared with earlier insulin analogues, second-generation basal insulins have improved pharmacokinetic/pharmacodynamic profiles that translate into clinical benefits, primarily reduced nocturnal-hypoglycaemia risk. Additional head-to-head comparisons of insulin degludec and insulin glargine 300 U/mL at bioequivalent doses, utilising continuous glucose monitoring and/or real-world evidence, are required to elucidate the differences in their pharmacological and clinical profiles." @default.
• W2903094977 created "2018-12-11" @default.
• W2903094977 creator A5030285366 @default.
• W2903094977 creator A5053050150 @default.
• W2903094977 creator A5054058644 @default.
• W2903094977 creator A5057323309 @default.
• W2903094977 creator A5078134786 @default.
• W2903094977 date "2019-09-01" @default.
• W2903094977 modified "2023-10-13" @default.
• W2903094977 title "Clinical relevance of pharmacokinetic and pharmacodynamic profiles of insulin degludec (100, 200 U/mL) and insulin glargine (100, 300 U/mL) – a review of evidence and clinical interpretation" @default.
• W2903094977 cites W1545770620 @default.
• W2903094977 cites W1565099151 @default.
• W2903094977 cites W1657095721 @default.
• W2903094977 cites W1658549429 @default.
• W2903094977 cites W1849264946 @default.
• W2903094977 cites W1981378897 @default.
• W2903094977 cites W2009042585 @default.
• W2903094977 cites W2016846562 @default.
• W2903094977 cites W2032996048 @default.
• W2903094977 cites W2038913714 @default.
• W2903094977 cites W2045319808 @default.
• W2903094977 cites W2061111352 @default.
• W2903094977 cites W2065510740 @default.
• W2903094977 cites W2066104891 @default.
• W2903094977 cites W2074588733 @default.
• W2903094977 cites W2080243591 @default.
• W2903094977 cites W2081755201 @default.
• W2903094977 cites W2089128745 @default.
• W2903094977 cites W2100633491 @default.
• W2903094977 cites W2100950755 @default.
• W2903094977 cites W2101427076 @default.
• W2903094977 cites W2118222360 @default.
• W2903094977 cites W2120910580 @default.
• W2903094977 cites W2122994980 @default.
• W2903094977 cites W2127521907 @default.
• W2903094977 cites W2133839434 @default.
• W2903094977 cites W2136164787 @default.
• W2903094977 cites W2137630151 @default.
• W2903094977 cites W2139040359 @default.
• W2903094977 cites W2142372141 @default.
• W2903094977 cites W2146550252 @default.
• W2903094977 cites W2150451787 @default.
• W2903094977 cites W2150617942 @default.
• W2903094977 cites W2194278435 @default.
• W2903094977 cites W2196199310 @default.
• W2903094977 cites W2211234866 @default.
• W2903094977 cites W2261116511 @default.
• W2903094977 cites W2278471634 @default.
• W2903094977 cites W2463897233 @default.
• W2903094977 cites W2474717831 @default.
• W2903094977 cites W2581151970 @default.
• W2903094977 cites W2586985323 @default.
• W2903094977 cites W2603131458 @default.
• W2903094977 cites W2624946723 @default.
• W2903094977 cites W2625031949 @default.
• W2903094977 cites W2724102092 @default.
• W2903094977 cites W2769528241 @default.
• W2903094977 cites W2770468706 @default.
• W2903094977 cites W2803400088 @default.
• W2903094977 cites W2887818979 @default.
• W2903094977 cites W2916155351 @default.
• W2903094977 cites W4230570152 @default.
• W2903094977 cites W4243765000 @default.
• W2903094977 doi "https://doi.org/10.1016/j.diabet.2018.11.004" @default.
• W2903094977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30496834" @default.
• W2903094977 hasPublicationYear "2019" @default.
• W2903094977 type Work @default.
• W2903094977 sameAs 2903094977 @default.
• W2903094977 citedByCount "12" @default.
• W2903094977 countsByYear W29030949772020 @default.
• W2903094977 countsByYear W29030949772021 @default.
• W2903094977 countsByYear W29030949772022 @default.
• W2903094977 countsByYear W29030949772023 @default.
• W2903094977 crossrefType "journal-article" @default.
• W2903094977 hasAuthorship W2903094977A5030285366 @default.
• W2903094977 hasAuthorship W2903094977A5053050150 @default.
• W2903094977 hasAuthorship W2903094977A5054058644 @default.
• W2903094977 hasAuthorship W2903094977A5057323309 @default.
• W2903094977 hasAuthorship W2903094977A5078134786 @default.
• W2903094977 hasBestOaLocation W29030949772 @default.
• W2903094977 hasConcept C111113717 @default.
• W2903094977 hasConcept C112705442 @default.
• W2903094977 hasConcept C126322002 @default.
• W2903094977 hasConcept C134018914 @default.
• W2903094977 hasConcept C2775927303 @default.
• W2903094977 hasConcept C2778024521 @default.
• W2903094977 hasConcept C2779306644 @default.
• W2903094977 hasConcept C2779920387 @default.
• W2903094977 hasConcept C2780668416 @default.
• W2903094977 hasConcept C71924100 @default.
• W2903094977 hasConcept C98274493 @default.
• W2903094977 hasConceptScore W2903094977C111113717 @default.
• W2903094977 hasConceptScore W2903094977C112705442 @default.
• W2903094977 hasConceptScore W2903094977C126322002 @default.
• W2903094977 hasConceptScore W2903094977C134018914 @default.
• W2903094977 hasConceptScore W2903094977C2775927303 @default.
• W2903094977 hasConceptScore W2903094977C2778024521 @default.
• W2903094977 hasConceptScore W2903094977C2779306644 @default.

• next