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• W2903124027 startingPage "40" @default.
• W2903124027 abstract "ATP-binding cassette (ABC) transporters are involved in a large number of processes and contribute to various human genetic diseases. Among other functions, ABC proteins are involved in the transport of multiple drugs through cells. Most of the genes coding for these transporters are highly polymorphic and DNA variants in these genes can affect the normal functioning of these proteins, affecting the way drugs are transported, increasing or decreasing drug levels. These changes in the intracellular and extracellular drug levels may be associated with altered drug effectiveness or severe drug-induced adverse events. This review presents a state-of-art of the most pharmacogenetics clinically relevant ABC transporters closed to the clinical implementation." @default.
• W2903124027 created "2018-12-11" @default.
• W2903124027 creator A5065955565 @default.
• W2903124027 date "2018-12-05" @default.
• W2903124027 modified "2023-09-30" @default.
• W2903124027 title "ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics" @default.
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• W2903124027 doi "https://doi.org/10.3390/jpm8040040" @default.
• W2903124027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313650" @default.
• W2903124027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30563187" @default.
• W2903124027 hasPublicationYear "2018" @default.
• W2903124027 type Work @default.
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