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• W2903142011 abstract "Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and switching to albumin in cases where crystalloids are insufficient. We evaluated hemodynamic response to crystalloids/colloids in critically ill adults. The primary research question was: “Are crystalloids sufficient for volume replacement in severe indications (intensive care unit [ICU]/critical illness)?” Randomized, controlled trials (RCTs) were identified using PubMed and EMBASE, and screened against predefined inclusion/exclusion criteria. Meta-analyses were performed on extracted data. Fifty-five RCTs (N = 27,036 patients) were eligible. Central venous pressure was significantly lower with crystalloids than with albumin, hydroxyethyl starch (HES), or gelatin (all p < .001). Mean arterial pressure was significantly lower with crystalloids vs. albumin (mean difference [MD]: −3.5 mm Hg; p = .03) or gelatin (MD: −9.2 mm Hg; p = .02). Significantly higher volumes of crystalloids were administered vs. HES (MD: +1775 mL); volume administered was numerically higher vs. albumin (MD: +1985 mL). Compared with the albumin group, cardiac index was significantly lower in the crystalloid group (MD: −0.6 L/min/m2, p < .001). All mortality and 90-day mortality were significantly lower for crystalloids compared with HES (relative risk 0.91; p = .009 and 0.9; p = .005, respectively). Crystalloids were less efficient than colloids at stabilizing resuscitation endpoints; guidance on when to switch is urgently required." @default.
• W2903142011 created "2018-12-11" @default.
• W2903142011 creator A5027973321 @default.
• W2903142011 creator A5031081653 @default.
• W2903142011 date "2019-04-01" @default.
• W2903142011 modified "2023-10-14" @default.
• W2903142011 title "Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis" @default.
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• W2903142011 doi "https://doi.org/10.1016/j.jcrc.2018.11.031" @default.
• W2903142011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30540968" @default.
• W2903142011 hasPublicationYear "2019" @default.
• W2903142011 type Work @default.

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