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• W2903190154 abstract "16S rRNA gene sequencing studies revealed that sex influences the taxonomic composition of gut bacteria in humans and rodents. The idea that sex-dependent differences in gut microbes are driven by sex steroid levels is supported by studies demonstrating that the gut microbiome diverges after puberty and that gonadectomy results in an altered gut microbiome. Recent studies demonstrated that changes in the gut microbiome are linked with androgen excess in women with PCOS and in female rodent models of the disorder. Studies reported that PCOS was associated with decreased alpha diversity and changes in the relative abundance of specific bacteria from the Bacteroidaceae, Clostridiaceae, Erysipelotrichidae, Lachnospiraceae, Lactobacillaceae, Porphyromonadaceae, Prevotellaceae, Ruminococcaceae, and S24-7 families previously linked with metabolic dysregulation. Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the gut microbiome may play a role in pathological situations of hormonal excess, such as PCOS. Indeed, studies demonstrated that PCOS is associated with decreased alpha diversity and changes in specific Bacteroidetes and Firmicutes, previously associated with metabolic dysregulation. These studies suggest that androgens may regulate the gut microbiome in females and that hyperandrogenism may be linked with a gut ‘dysbiosis’ in PCOS. Future mechanistic studies will be required to elucidate how sex steroids regulate the composition and function of the gut microbial community and what the consequences of this regulation are for the host. Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the gut microbiome may play a role in pathological situations of hormonal excess, such as PCOS. Indeed, studies demonstrated that PCOS is associated with decreased alpha diversity and changes in specific Bacteroidetes and Firmicutes, previously associated with metabolic dysregulation. These studies suggest that androgens may regulate the gut microbiome in females and that hyperandrogenism may be linked with a gut ‘dysbiosis’ in PCOS. Future mechanistic studies will be required to elucidate how sex steroids regulate the composition and function of the gut microbial community and what the consequences of this regulation are for the host. steroid hormone signaling which causes transient effects on specific cellular processes that are reversible upon removal of the hormone. represents the number of different species within a specific community or individual sample. gram-negative bacteria that are one of the two predominant phyla present in the mammalian gut. represents how similar one community or individual sample is to another. enzyme synthesized in gut bacteria that deconjugates host-derived molecules such as bilirubin, neurotransmitters, and hormones that were previously conjugated in the liver. mostly gram-positive bacteria that are one of the two predominant phyla present in the mammalian gut. non-steroidal inhibitor of aromatase (the enzyme responsible for the conversion of testosterone to estrogen). also known as endotoxin, LPS is the major component of the outer membrane of gram-negative bacteria. LPS activation of Toll-like receptor 4 results in cytokine production and activation of the innate immune system. exposure to sex steroid hormones during development (e.g., in prenatal or early postnatal periods), which has been shown to result in permanent changes in tissues and organs such as the brain. universal primers containing distinct barcodes are used to amplify a region of the bacterial 16S ribosomal RNA gene in fecal or cecum samples and the resulting amplicons are pooled, purified, and sequenced." @default.
• W2903190154 created "2018-12-11" @default.
• W2903190154 creator A5042178162 @default.
• W2903190154 date "2019-01-01" @default.
• W2903190154 modified "2023-10-11" @default.
• W2903190154 title "Sex, Microbes, and Polycystic Ovary Syndrome" @default.
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• W2903190154 doi "https://doi.org/10.1016/j.tem.2018.11.001" @default.
• W2903190154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309599" @default.
• W2903190154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30503354" @default.
• W2903190154 hasPublicationYear "2019" @default.
• W2903190154 type Work @default.
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