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• W2903195952 abstract "Ralstonia solanacearum, one of the most destructive plant bacterial pathogens, delivers an array of effector proteins via its type III secretion system for pathogenesis. However, the biochemical functions of most of these proteins remain unclear. RipN is a type III effector with unknown function(s) from the pathogen R. solanacearum. Here, we demonstrate that RipN is a conserved type III effector found within the R. solanacearum species complex that contains a putative Nudix hydrolase domain and has ADP-ribose/NADH pyrophosphorylase activity in vitro. Further analysis shows that RipN localizes to the endoplasmic reticulum (ER) and nucleus in Nicotiana tabacum leaf cells and Arabidopsis protoplasts, and truncation of the C-terminus of RipN results in a loss of nuclear and ER targeting. Furthermore, the expression of RipN in Arabidopsis suppresses callose deposition and the transcription of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) marker genes under flg22 treatment, and promotes bacterial growth in planta. In addition, the expression of RipN in plant cells alters NADH/NAD+, but not GSH/GSSG, ratios, and its Nudix hydrolase activity is indispensable for such biochemical function. These results suggest that RipN acts as a Nudix hydrolase, alters the NADH/NAD+ ratio of the plant and contributes to R. solanacearum virulence by suppression of PTI of the host." @default.
• W2903195952 created "2018-12-11" @default.
• W2903195952 creator A5007139271 @default.
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• W2903195952 date "2019-02-18" @default.
• W2903195952 modified "2023-10-11" @default.
• W2903195952 title "The <i>Ralstonia solanacearum</i> effector RipN suppresses plant PAMP‐triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD ⁺ ratio in <i>Arabidopsis</i>" @default.
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• W2903195952 doi "https://doi.org/10.1111/mpp.12773" @default.
• W2903195952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6637912" @default.
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