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- W2903236847 abstract "Transcription-translation feedback loops that comprise eukaryotic circadian clocks rely upon temporal delays that separate the phase of active transcription of clock genes, such as Drosophila period (per) and timeless (tim), from negative feedback by the two proteins. However, our understanding of the mechanisms involved is incomplete. Through an RNA interference screen, we found that pre-mRNA processing 4 (PRP4) kinase, a component of the U4/U5.U6 triple small nuclear ribonucleoprotein (tri-snRNP) spliceosome, and other tri-snRNP components regulate cycling of the molecular clock as well as rest:activity rhythms. Unbiased RNA-Sequencing uncovered an alternatively spliced intron in tim whose increased retention upon prp4 downregulation leads to decreased TIM levels. We demonstrate that the splicing of tim is rhythmic with a phase that parallels delayed accumulation of the protein in a 24 hr cycle. We propose that alternative splicing constitutes an important clock mechanism for delaying the daily accumulation of clock proteins, and thereby negative feedback by them. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type=decision-letter rid=SA1>see decision letter</xref>)." @default.
- W2903236847 created "2018-12-11" @default.
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- W2903236847 date "2018-12-05" @default.
- W2903236847 modified "2023-09-25" @default.
- W2903236847 title "Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila" @default.
- W2903236847 cites W1599101054 @default.
- W2903236847 cites W1908980975 @default.
- W2903236847 cites W1947483389 @default.
- W2903236847 cites W1963583940 @default.
- W2903236847 cites W1968410906 @default.
- W2903236847 cites W1972399183 @default.
- W2903236847 cites W1975635900 @default.
- W2903236847 cites W1978520851 @default.
- W2903236847 cites W1980432902 @default.
- W2903236847 cites W1987607182 @default.
- W2903236847 cites W1997932809 @default.
- W2903236847 cites W1999182669 @default.
- W2903236847 cites W2002640650 @default.
- W2903236847 cites W2005174604 @default.
- W2903236847 cites W2007059220 @default.
- W2903236847 cites W2009221497 @default.
- W2903236847 cites W2020449594 @default.
- W2903236847 cites W2021819115 @default.
- W2903236847 cites W2027324767 @default.
- W2903236847 cites W2031483444 @default.
- W2903236847 cites W2032149289 @default.
- W2903236847 cites W2040561723 @default.
- W2903236847 cites W2040617029 @default.
- W2903236847 cites W2046290772 @default.
- W2903236847 cites W2052915113 @default.
- W2903236847 cites W2056296605 @default.
- W2903236847 cites W2056393772 @default.
- W2903236847 cites W2056395995 @default.
- W2903236847 cites W2060138058 @default.
- W2903236847 cites W2064455466 @default.
- W2903236847 cites W2071307982 @default.
- W2903236847 cites W2072267291 @default.
- W2903236847 cites W2076696166 @default.
- W2903236847 cites W2077853668 @default.
- W2903236847 cites W2084548353 @default.
- W2903236847 cites W2086967162 @default.
- W2903236847 cites W2091287207 @default.
- W2903236847 cites W2091953892 @default.
- W2903236847 cites W2092940521 @default.
- W2903236847 cites W2093173577 @default.
- W2903236847 cites W2106446195 @default.
- W2903236847 cites W2112696178 @default.
- W2903236847 cites W2120418467 @default.
- W2903236847 cites W2120887723 @default.
- W2903236847 cites W2125422443 @default.
- W2903236847 cites W2126304021 @default.
- W2903236847 cites W2127032292 @default.
- W2903236847 cites W2131467952 @default.
- W2903236847 cites W2131794531 @default.
- W2903236847 cites W2141458291 @default.
- W2903236847 cites W2143350291 @default.
- W2903236847 cites W2145517507 @default.
- W2903236847 cites W2146512944 @default.
- W2903236847 cites W2146575770 @default.
- W2903236847 cites W2148529262 @default.
- W2903236847 cites W2153009644 @default.
- W2903236847 cites W2154333461 @default.
- W2903236847 cites W2157066823 @default.
- W2903236847 cites W2157561436 @default.
- W2903236847 cites W2162614828 @default.
- W2903236847 cites W2163729475 @default.
- W2903236847 cites W2166021928 @default.
- W2903236847 cites W2166082115 @default.
- W2903236847 cites W2166820820 @default.
- W2903236847 cites W2169456326 @default.
- W2903236847 cites W2171827152 @default.
- W2903236847 cites W2172189627 @default.
- W2903236847 cites W2225873253 @default.
- W2903236847 cites W2346964101 @default.
- W2903236847 cites W2564809379 @default.
- W2903236847 cites W2586842855 @default.
- W2903236847 cites W2604410021 @default.
- W2903236847 cites W2743757702 @default.
- W2903236847 cites W2788464253 @default.
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- W2903236847 doi "https://doi.org/10.7554/elife.39821" @default.
- W2903236847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6281371" @default.
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- W2903236847 hasPublicationYear "2018" @default.
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