Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903238853> ?p ?o ?g. }
- W2903238853 endingPage "1511" @default.
- W2903238853 startingPage "1499" @default.
- W2903238853 abstract "Aberrant expression of noncoding RNAs plays a critical role during tumorigenesis. To uncover novel functions of long non-coding RNA (lncRNA) in lung adenocarcinoma, we used a microarray-based screen identifying LINC00673 with elevated expression in matched tumor versus normal tissue. We report that loss of LINC00673 is sufficient to trigger cellular senescence, a tumor suppressive mechanism associated with permanent cell cycle arrest, both in lung cancer and normal cells in a p53-dependent manner. LINC00673-depleted cells fail to efficiently transit from G1- to S-phase. Using a quantitative proteomics approach, we confirm the modulation of senescence-associated genes as a result of LINC00673 knockdown. In addition, we uncover that depletion of p53 in normal and tumor cells is sufficient to overcome LINC00673-mediated cell cycle arrest and cellular senescence. Furthermore, we report that overexpression of LINC00673 reduces p53 translation and contributes to the bypass of Ras-induced senescence. In summary, our findings highlight LINC00673 as a crucial regulator of proliferation and cellular senescence in lung cancer." @default.
- W2903238853 created "2018-12-11" @default.
- W2903238853 creator A5016216382 @default.
- W2903238853 creator A5024274370 @default.
- W2903238853 creator A5035147308 @default.
- W2903238853 creator A5035438953 @default.
- W2903238853 creator A5035465677 @default.
- W2903238853 creator A5040695029 @default.
- W2903238853 creator A5041701276 @default.
- W2903238853 creator A5042195436 @default.
- W2903238853 creator A5042590633 @default.
- W2903238853 creator A5046577049 @default.
- W2903238853 creator A5065509965 @default.
- W2903238853 creator A5067961756 @default.
- W2903238853 creator A5072920250 @default.
- W2903238853 creator A5085505239 @default.
- W2903238853 creator A5086486331 @default.
- W2903238853 date "2018-12-02" @default.
- W2903238853 modified "2023-10-01" @default.
- W2903238853 title "Targeting <i>LINC00673</i> expression triggers cellular senescence in lung cancer" @default.
- W2903238853 cites W1843014747 @default.
- W2903238853 cites W1913646446 @default.
- W2903238853 cites W1926685779 @default.
- W2903238853 cites W1954825675 @default.
- W2903238853 cites W1957438118 @default.
- W2903238853 cites W1964113455 @default.
- W2903238853 cites W1970924670 @default.
- W2903238853 cites W1972295452 @default.
- W2903238853 cites W1975288407 @default.
- W2903238853 cites W1976149758 @default.
- W2903238853 cites W1977972521 @default.
- W2903238853 cites W1978888457 @default.
- W2903238853 cites W1979101646 @default.
- W2903238853 cites W1980886467 @default.
- W2903238853 cites W1980914060 @default.
- W2903238853 cites W1982395176 @default.
- W2903238853 cites W1984952409 @default.
- W2903238853 cites W1989652106 @default.
- W2903238853 cites W2003521072 @default.
- W2903238853 cites W2003553455 @default.
- W2903238853 cites W2016489352 @default.
- W2903238853 cites W2019562165 @default.
- W2903238853 cites W2027065741 @default.
- W2903238853 cites W2030658020 @default.
- W2903238853 cites W2040618717 @default.
- W2903238853 cites W2041156660 @default.
- W2903238853 cites W2045518196 @default.
- W2903238853 cites W2050901509 @default.
- W2903238853 cites W2050982262 @default.
- W2903238853 cites W2058886425 @default.
- W2903238853 cites W2061881549 @default.
- W2903238853 cites W2067117191 @default.
- W2903238853 cites W2071271349 @default.
- W2903238853 cites W2071462293 @default.
- W2903238853 cites W2079588819 @default.
- W2903238853 cites W2080769506 @default.
- W2903238853 cites W2082663907 @default.
- W2903238853 cites W2087377443 @default.
- W2903238853 cites W2087404852 @default.
- W2903238853 cites W2088293068 @default.
- W2903238853 cites W2095469838 @default.
- W2903238853 cites W2100441605 @default.
- W2903238853 cites W2103235451 @default.
- W2903238853 cites W2104908670 @default.
- W2903238853 cites W2108796882 @default.
- W2903238853 cites W2115852450 @default.
- W2903238853 cites W2116437342 @default.
- W2903238853 cites W2118603880 @default.
- W2903238853 cites W2121371748 @default.
- W2903238853 cites W2124614845 @default.
- W2903238853 cites W2124954099 @default.
- W2903238853 cites W2130313087 @default.
- W2903238853 cites W2130687298 @default.
- W2903238853 cites W2133444314 @default.
- W2903238853 cites W2136086657 @default.
- W2903238853 cites W2150740687 @default.
- W2903238853 cites W2150748567 @default.
- W2903238853 cites W2151221689 @default.
- W2903238853 cites W2156150950 @default.
- W2903238853 cites W2158936746 @default.
- W2903238853 cites W2159380507 @default.
- W2903238853 cites W2160333540 @default.
- W2903238853 cites W2160671118 @default.
- W2903238853 cites W2161811833 @default.
- W2903238853 cites W2162189448 @default.
- W2903238853 cites W2166810745 @default.
- W2903238853 cites W2170634473 @default.
- W2903238853 cites W2254791612 @default.
- W2903238853 cites W2309190920 @default.
- W2903238853 cites W2320228714 @default.
- W2903238853 cites W2397759082 @default.
- W2903238853 cites W2401641277 @default.
- W2903238853 cites W2566306318 @default.
- W2903238853 cites W2582886239 @default.
- W2903238853 cites W2597282914 @default.
- W2903238853 cites W2735000611 @default.
- W2903238853 cites W2755439655 @default.
- W2903238853 cites W2917837889 @default.