FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903260342> ?p ?o ?g. }

• W2903260342 abstract "Abstract Insulin deficiency in type 1 diabetes (T1D) is generally considered a consequence of specific beta-cell loss. Since healthy pancreatic islets consist of ~65% beta cells, this would lead to reduced islet size if the beta cells are not replaced by other cells or tissue. The number of islets per pancreas volume (islet density) would not be affected. In this study, we compared the islet density, size, and size distribution in subjects with recent-onset or long-standing T1D, with that in matched non-diabetic subjects. Results show that subjects with T1D, regardless of disease duration, had a dramatically reduced islet number per mm 2 , while the islet size was similar in all groups. Insulin-negative islets in T1D subjects were dominated by glucagon-positive cells that frequently had lost the alpha-cell transcription factor ARX while instead expressing PDX1, normally expressed in beta cells. Based on our findings, we propose that failure during childhood to establish a sufficient islet number to reach the beta-cell mass needed to cope with episodes of increased insulin demand contributes to T1D susceptibility. Exhaustion induced by relative lack of beta cells could then potentially drive beta-cell dedifferentiation to alpha-cells, explaining the preserved islet size observed in T1D compared to controls." @default.
• W2903260342 created "2018-12-11" @default.
• W2903260342 creator A5006823994 @default.
• W2903260342 creator A5021685227 @default.
• W2903260342 creator A5044921536 @default.
• W2903260342 creator A5052605298 @default.
• W2903260342 creator A5055673489 @default.
• W2903260342 creator A5076033234 @default.
• W2903260342 creator A5090718680 @default.
• W2903260342 date "2018-11-29" @default.
• W2903260342 modified "2023-09-27" @default.
• W2903260342 title "Characterization of the endocrine pancreas in Type 1 Diabetes: islet size is maintained but islet number is markedly reduced" @default.
• W2903260342 cites W1967766455 @default.
• W2903260342 cites W2007611342 @default.
• W2903260342 cites W2036682769 @default.
• W2903260342 cites W2044949683 @default.
• W2903260342 cites W2088945279 @default.
• W2903260342 cites W2129976178 @default.
• W2903260342 cites W2132289617 @default.
• W2903260342 cites W2140655516 @default.
• W2903260342 cites W2148147368 @default.
• W2903260342 cites W2149895222 @default.
• W2903260342 cites W2151338950 @default.
• W2903260342 cites W2152704466 @default.
• W2903260342 cites W2159852644 @default.
• W2903260342 cites W2164051346 @default.
• W2903260342 cites W2166770877 @default.
• W2903260342 cites W2175468670 @default.
• W2903260342 cites W2199891677 @default.
• W2903260342 cites W2330788525 @default.
• W2903260342 cites W2331012321 @default.
• W2903260342 cites W2562863032 @default.
• W2903260342 cites W2581716463 @default.
• W2903260342 cites W2789611122 @default.
• W2903260342 doi "https://doi.org/10.1101/480509" @default.
• W2903260342 hasPublicationYear "2018" @default.
• W2903260342 type Work @default.
• W2903260342 sameAs 2903260342 @default.
• W2903260342 citedByCount "2" @default.
• W2903260342 countsByYear W29032603422019 @default.
• W2903260342 crossrefType "posted-content" @default.
• W2903260342 hasAuthorship W2903260342A5006823994 @default.
• W2903260342 hasAuthorship W2903260342A5021685227 @default.
• W2903260342 hasAuthorship W2903260342A5044921536 @default.
• W2903260342 hasAuthorship W2903260342A5052605298 @default.
• W2903260342 hasAuthorship W2903260342A5055673489 @default.
• W2903260342 hasAuthorship W2903260342A5076033234 @default.
• W2903260342 hasAuthorship W2903260342A5090718680 @default.
• W2903260342 hasBestOaLocation W29032603421 @default.
• W2903260342 hasConcept C126322002 @default.
• W2903260342 hasConcept C134018914 @default.
• W2903260342 hasConcept C165220095 @default.
• W2903260342 hasConcept C199360897 @default.
• W2903260342 hasConcept C2776174256 @default.
• W2903260342 hasConcept C2776828364 @default.
• W2903260342 hasConcept C2778563252 @default.
• W2903260342 hasConcept C2778764654 @default.
• W2903260342 hasConcept C2779050171 @default.
• W2903260342 hasConcept C2779306644 @default.
• W2903260342 hasConcept C2781232474 @default.
• W2903260342 hasConcept C41008148 @default.
• W2903260342 hasConcept C46699223 @default.
• W2903260342 hasConcept C555293320 @default.
• W2903260342 hasConcept C71315377 @default.
• W2903260342 hasConcept C71924100 @default.
• W2903260342 hasConcept C86803240 @default.
• W2903260342 hasConceptScore W2903260342C126322002 @default.
• W2903260342 hasConceptScore W2903260342C134018914 @default.
• W2903260342 hasConceptScore W2903260342C165220095 @default.
• W2903260342 hasConceptScore W2903260342C199360897 @default.
• W2903260342 hasConceptScore W2903260342C2776174256 @default.
• W2903260342 hasConceptScore W2903260342C2776828364 @default.
• W2903260342 hasConceptScore W2903260342C2778563252 @default.
• W2903260342 hasConceptScore W2903260342C2778764654 @default.
• W2903260342 hasConceptScore W2903260342C2779050171 @default.
• W2903260342 hasConceptScore W2903260342C2779306644 @default.
• W2903260342 hasConceptScore W2903260342C2781232474 @default.
• W2903260342 hasConceptScore W2903260342C41008148 @default.
• W2903260342 hasConceptScore W2903260342C46699223 @default.
• W2903260342 hasConceptScore W2903260342C555293320 @default.
• W2903260342 hasConceptScore W2903260342C71315377 @default.
• W2903260342 hasConceptScore W2903260342C71924100 @default.
• W2903260342 hasConceptScore W2903260342C86803240 @default.
• W2903260342 hasLocation W29032603421 @default.
• W2903260342 hasLocation W29032603422 @default.
• W2903260342 hasOpenAccess W2903260342 @default.
• W2903260342 hasPrimaryLocation W29032603421 @default.
• W2903260342 hasRelatedWork W1583213500 @default.
• W2903260342 hasRelatedWork W1981564790 @default.
• W2903260342 hasRelatedWork W1984592363 @default.
• W2903260342 hasRelatedWork W2017797235 @default.
• W2903260342 hasRelatedWork W2024312973 @default.
• W2903260342 hasRelatedWork W2028699422 @default.
• W2903260342 hasRelatedWork W2084878141 @default.
• W2903260342 hasRelatedWork W2402098708 @default.
• W2903260342 hasRelatedWork W2406617150 @default.
• W2903260342 hasRelatedWork W2971921045 @default.
• W2903260342 isParatext "false" @default.
• W2903260342 isRetracted "false" @default.
• W2903260342 magId "2903260342" @default.

• next