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• W2903282258 abstract "In our approach to synthesize bioactive molecules, a series of novel N ‐heterocycles were synthesized and evaluated for their in vitro antitumor activity against a panel of three human cancer cell lines, namely, human breast cancer cell line (MCF‐7), human cervical cancer cell line (HeLa), and human prostate cancer PC‐3. The majority of the tested compounds exhibited significant cytotoxic activity toward the tested tumor cell lines. Analogues 33 , 34 , 31 , 38 , 21 , 23 , 22 , and 20 exhibited considerable cytotoxic activities comparable with standard drug 5‐fuorouracil. Compound 33 displayed superior cytotoxicity with IC 50 value of 4.12 ± 1.21 μg/mL against HeLa tumor cell line." @default.
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• W2903282258 date "2018-12-02" @default.
• W2903282258 modified "2023-09-26" @default.
• W2903282258 title "4‐Chlorothiazole‐5‐carbaldehydes as Potent Precursors for Synthesis of Some New Pendant <i>N</i> ‐heterocyces Endowed with Anti‐Tumor Activity" @default.
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• W2903282258 doi "https://doi.org/10.1002/jhet.3406" @default.
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