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- W2903294363 abstract "Summary Pf filamentous prophages are prevalent among clinical and environmental Pseudomonas aeruginosa isolates. Pf4 and Pf5 prophages are integrated into the host genomes of PAO1 and PA14, respectively, and play an important role in biofilm development. However, the genetic factors that directly control the lysis‐lysogeny switch in Pf prophages remain unclear. Here, we identified and characterized the excisionase genes in Pf4 and Pf5 (named xisF4 and xisF5 , respectively). XisF4 and XisF5 represent two major subfamilies of functional excisionases and are commonly found in Pf prophages. While both of them can significantly promote prophage excision, only XisF5 is essential for Pf5 excision. XisF4 activates Pf4 phage replication by upregulating the phage initiator gene ( PA0727 ). In addition, xisF4 and the neighboring phage repressor c gene pf4r are transcribed divergently and their 5′‐untranslated regions overlap. XisF4 and Pf4r not only auto‐activate their own expression but also repress each other. Furthermore, two H‐NS family proteins, MvaT and MvaU, coordinately repress Pf4 production by directly repressing xisF4 . Collectively, we reveal that Pf prophage excisionases cooperate in controlling lysogeny and phage production." @default.
- W2903294363 created "2018-12-11" @default.
- W2903294363 creator A5013881064 @default.
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- W2903294363 creator A5082971893 @default.
- W2903294363 date "2018-12-12" @default.
- W2903294363 modified "2023-10-18" @default.
- W2903294363 title "Excisionase in Pf filamentous prophage controls lysis‐lysogeny decision‐making in <i>Pseudomonas aeruginosa</i>" @default.
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- W2903294363 doi "https://doi.org/10.1111/mmi.14170" @default.
- W2903294363 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7379572" @default.
- W2903294363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30475408" @default.
- W2903294363 hasPublicationYear "2018" @default.
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