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- W2903315036 endingPage "12596" @default.
- W2903315036 startingPage "12576" @default.
- W2903315036 abstract "Abstract Temperature regulation is an indispensable physiological activity critical for animal survival. However, relatively little is known about the origin of thermoregulatory regimes in a phylogenetic context, or the genetic mechanisms driving the evolution of these regimes. Using bats as a study system, we examined the evolution of three thermoregulatory regimes (hibernation, daily heterothermy, and homeothermy) in relation to the evolution of leptin, a protein implicated in regulation of torpor bouts in mammals, including bats. A threshold model was used to test for a correlation between lineages with positively selected lep, the gene encoding leptin, and the thermoregulatory regimes of those lineages. Although evidence for episodic positive selection of lep was found, positive selection was not correlated with lineages of heterothermic bats, a finding that contradicts results from previous studies. Evidence from our ancestral state reconstructions suggests that the most recent common ancestor of bats used daily heterothermy and that the presence of hibernation is highly unlikely at this node. Hibernation likely evolved independently at least four times in bats—once in the common ancestor of Vespertilionidae and Molossidae, once in the clade containing Rhinolophidae and Rhinopomatidae, and again independently in the lineages leading to Taphozous melanopogon and Mystacina tuberculata . Our reconstructions revealed that thermoregulatory regimes never transitioned directly from hibernation to homeothermy, or the reverse, in the evolutionary history of bats. This, in addition to recent evidence that heterothermy is best described along a continuum, suggests that thermoregulatory regimes in mammals are best represented as an ordered continuous trait (homeothermy ← → daily torpor ← → hibernation) rather than as the three discrete regimes that evolve in an unordered fashion. These results have important implications for methodological approaches in future physiological and evolutionary research." @default.
- W2903315036 created "2018-12-11" @default.
- W2903315036 creator A5025782207 @default.
- W2903315036 creator A5031622809 @default.
- W2903315036 creator A5060910133 @default.
- W2903315036 date "2018-11-28" @default.
- W2903315036 modified "2023-09-25" @default.
- W2903315036 title "Hibernation in bats (Mammalia: Chiroptera) did not evolve through positive selection of leptin" @default.
- W2903315036 cites W111662785 @default.
- W2903315036 cites W1481560909 @default.
- W2903315036 cites W1489679817 @default.
- W2903315036 cites W1494816515 @default.
- W2903315036 cites W1605984840 @default.
- W2903315036 cites W1761291506 @default.
- W2903315036 cites W1818355168 @default.
- W2903315036 cites W1881892409 @default.
- W2903315036 cites W1888865019 @default.
- W2903315036 cites W1900804070 @default.
- W2903315036 cites W1908559221 @default.
- W2903315036 cites W1965063038 @default.
- W2903315036 cites W1966349957 @default.
- W2903315036 cites W1967072590 @default.
- W2903315036 cites W1968675556 @default.
- W2903315036 cites W1969481941 @default.
- W2903315036 cites W1971094641 @default.
- W2903315036 cites W1973175580 @default.
- W2903315036 cites W1974581784 @default.
- W2903315036 cites W1976851581 @default.
- W2903315036 cites W1977049832 @default.
- W2903315036 cites W1977483949 @default.
- W2903315036 cites W1978270447 @default.
- W2903315036 cites W1979448743 @default.
- W2903315036 cites W1980700473 @default.
- W2903315036 cites W1981417442 @default.
- W2903315036 cites W1982167713 @default.
- W2903315036 cites W1983227991 @default.
- W2903315036 cites W1983736454 @default.
- W2903315036 cites W1983899854 @default.
- W2903315036 cites W1988608740 @default.
- W2903315036 cites W1992714434 @default.
- W2903315036 cites W1993633083 @default.
- W2903315036 cites W1994433056 @default.
- W2903315036 cites W1995671390 @default.
- W2903315036 cites W1996704250 @default.
- W2903315036 cites W1997655974 @default.
- W2903315036 cites W1999689684 @default.
- W2903315036 cites W2005353575 @default.
- W2903315036 cites W2010235693 @default.
- W2903315036 cites W2011212474 @default.
- W2903315036 cites W2011733436 @default.
- W2903315036 cites W2013172881 @default.
- W2903315036 cites W2014152801 @default.
- W2903315036 cites W2018868598 @default.
- W2903315036 cites W2019760571 @default.
- W2903315036 cites W2022733476 @default.
- W2903315036 cites W2024401943 @default.
- W2903315036 cites W2024844093 @default.
- W2903315036 cites W2025942236 @default.
- W2903315036 cites W2026965565 @default.
- W2903315036 cites W2027717797 @default.
- W2903315036 cites W2029549914 @default.
- W2903315036 cites W2032088933 @default.
- W2903315036 cites W2032674526 @default.
- W2903315036 cites W2033980801 @default.
- W2903315036 cites W2035176358 @default.
- W2903315036 cites W2042106843 @default.
- W2903315036 cites W2042594196 @default.
- W2903315036 cites W2042829320 @default.
- W2903315036 cites W2043723572 @default.
- W2903315036 cites W2044044562 @default.
- W2903315036 cites W2044929577 @default.
- W2903315036 cites W2045185453 @default.
- W2903315036 cites W2047863167 @default.
- W2903315036 cites W2059451672 @default.
- W2903315036 cites W2059564770 @default.
- W2903315036 cites W2060138288 @default.
- W2903315036 cites W2061173653 @default.
- W2903315036 cites W2062302492 @default.
- W2903315036 cites W2063294979 @default.
- W2903315036 cites W2063497067 @default.
- W2903315036 cites W2064365050 @default.
- W2903315036 cites W2064916053 @default.
- W2903315036 cites W2073508111 @default.
- W2903315036 cites W2074657110 @default.
- W2903315036 cites W2075158663 @default.
- W2903315036 cites W2076782363 @default.
- W2903315036 cites W2077239328 @default.
- W2903315036 cites W2077595219 @default.
- W2903315036 cites W2077607945 @default.
- W2903315036 cites W2078409267 @default.
- W2903315036 cites W2079434977 @default.
- W2903315036 cites W2082717652 @default.
- W2903315036 cites W2083203579 @default.
- W2903315036 cites W2085006201 @default.
- W2903315036 cites W2087133453 @default.
- W2903315036 cites W2091963542 @default.
- W2903315036 cites W2092124336 @default.
- W2903315036 cites W2092803574 @default.