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• W2903322966 endingPage "101612" @default.
• W2903322966 startingPage "101612" @default.
• W2903322966 abstract "Subjective cognitive decline (SCD) patients are considered as a risk population for preclinical Alzheimer's Disease (AD). Supporting this idea, previous studies in SCD populations report subtle alterations in various cognitive and neuroimaging biomarkers that are typically affected during AD progression. To extend these observations, the present study examined whether SCD patients show atrophy of cholinergic basal forebrain nuclei (chBFN), analogous with recent findings in prodromal and clinical AD patients. We assessed volume reductions of the chBFN in 24 SCD subjects compared to 49 matched controls on 3D-T1-weighted MR images based on a postmortem derived atlas. Furthermore, we assessed whether chBFN atrophy was linked with cognitive, structural and metabolic biomarker alterations we previously reported in this SCD cohort: Using correlation analyses we tested for associations between the volumes of the chBFN with the hippocampal gray matter volume, and posterior medial glucose consumption, and the trajectory of verbal memory performance. The SCD cases showed a significant total volume reduction of the chBFN, with largest effect sizes in the Ch1/2 and Ch4p subdivisions of the chBFN. The latter was associated with a reduced glucose metabolism in the precuneus for the SCD group only. These data show an early involvement of the cholinergic basal forebrain nuclei in SCD predominantly in Ch1/2 and Ch4p which supports the conceptual link between SCD and preclinical AD." @default.
• W2903322966 created "2018-12-11" @default.
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• W2903322966 date "2019-01-01" @default.
• W2903322966 modified "2023-10-13" @default.
• W2903322966 title "Subregional volume reduction of the cholinergic forebrain in subjective cognitive decline (SCD)" @default.
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• W2903322966 cites W1867921149 @default.
• W2903322966 cites W1969694170 @default.
• W2903322966 cites W1970858190 @default.
• W2903322966 cites W1974446489 @default.
• W2903322966 cites W1978599499 @default.
• W2903322966 cites W1980111435 @default.
• W2903322966 cites W1980657066 @default.
• W2903322966 cites W1980939518 @default.
• W2903322966 cites W1981036614 @default.
• W2903322966 cites W1982064952 @default.
• W2903322966 cites W1987033987 @default.
• W2903322966 cites W1990331183 @default.
• W2903322966 cites W1995779519 @default.
• W2903322966 cites W1997160768 @default.
• W2903322966 cites W1997807985 @default.
• W2903322966 cites W2000555003 @default.
• W2903322966 cites W2000658130 @default.
• W2903322966 cites W2001526304 @default.
• W2903322966 cites W2011195206 @default.
• W2903322966 cites W2012582740 @default.
• W2903322966 cites W2013854477 @default.
• W2903322966 cites W2014349545 @default.
• W2903322966 cites W2018434736 @default.
• W2903322966 cites W2025543844 @default.
• W2903322966 cites W2032687881 @default.
• W2903322966 cites W2033729598 @default.
• W2903322966 cites W2034491173 @default.
• W2903322966 cites W2041826751 @default.
• W2903322966 cites W2042250149 @default.
• W2903322966 cites W2046250855 @default.
• W2903322966 cites W2048505725 @default.
• W2903322966 cites W2049100671 @default.
• W2903322966 cites W2052412310 @default.
• W2903322966 cites W2053231405 @default.
• W2903322966 cites W2054899104 @default.
• W2903322966 cites W2062151508 @default.
• W2903322966 cites W2067495470 @default.
• W2903322966 cites W2080071110 @default.
• W2903322966 cites W2080374512 @default.
• W2903322966 cites W2082506470 @default.
• W2903322966 cites W2085781805 @default.
• W2903322966 cites W2097750812 @default.
• W2903322966 cites W2098732596 @default.
• W2903322966 cites W2101081940 @default.
• W2903322966 cites W2102099319 @default.
• W2903322966 cites W2104227586 @default.
• W2903322966 cites W2107537187 @default.
• W2903322966 cites W2109140840 @default.
• W2903322966 cites W2111464173 @default.
• W2903322966 cites W2111493525 @default.
• W2903322966 cites W2111774300 @default.
• W2903322966 cites W2118421222 @default.
• W2903322966 cites W2127591453 @default.
• W2903322966 cites W2129497119 @default.
• W2903322966 cites W2136631323 @default.
• W2903322966 cites W2141650485 @default.
• W2903322966 cites W2142904655 @default.
• W2903322966 cites W2144631174 @default.
• W2903322966 cites W2148555056 @default.
• W2903322966 cites W2150223607 @default.
• W2903322966 cites W2152185487 @default.
• W2903322966 cites W2155298532 @default.
• W2903322966 cites W2158415185 @default.
• W2903322966 cites W2158766477 @default.
• W2903322966 cites W2160475077 @default.
• W2903322966 cites W2164856255 @default.
• W2903322966 cites W2167834847 @default.
• W2903322966 cites W2168745915 @default.
• W2903322966 cites W2171449979 @default.
• W2903322966 cites W2171487159 @default.
• W2903322966 cites W2402726961 @default.
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• W2903322966 doi "https://doi.org/10.1016/j.nicl.2018.101612" @default.
• W2903322966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6413297" @default.
• W2903322966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30555006" @default.
• W2903322966 hasPublicationYear "2019" @default.
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