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- W2903326024 abstract "The lipin phosphatidic acid phosphatase (PAP) enzymes are required for triacylglycerol (TAG) synthesis from glycerol 3-phosphate in most mammalian tissues. The 3 lipin proteins (lipin 1, lipin 2, and lipin 3) each have PAP activity, but have distinct tissue distributions, with lipin 1 being the predominant PAP enzyme in many metabolic tissues. One exception is the small intestine, which is unique in expressing exclusively lipin 2 and lipin 3. TAG synthesis in small intestinal enterocytes utilizes 2-monoacylglycerol and does not require the PAP reaction, making the role of lipin proteins in enterocytes unclear. Enterocyte TAGs are stored transiently as cytosolic lipid droplets or incorporated into lipoproteins (chylomicrons) for secretion. We determined that lipin enzymes are critical for chylomicron biogenesis, through regulation of membrane phospholipid composition and association of apolipoprotein B48 with nascent chylomicron particles. Lipin 2/3 deficiency caused phosphatidic acid accumulation and mammalian target of rapamycin complex 1 (mTORC1) activation, which were associated with enhanced protein levels of a key phospholipid biosynthetic enzyme (CTP:phosphocholine cytidylyltransferase α) and altered membrane phospholipid composition. Impaired chylomicron synthesis in lipin 2/3 deficiency could be rescued by normalizing phospholipid synthesis levels. These data implicate lipin 2/3 as a control point for enterocyte phospholipid homeostasis and chylomicron biogenesis." @default.
- W2903326024 created "2018-12-11" @default.
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- W2903326024 date "2018-12-03" @default.
- W2903326024 modified "2023-10-12" @default.
- W2903326024 title "Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis" @default.
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- W2903326024 cites W1531695174 @default.
- W2903326024 cites W1898926425 @default.
- W2903326024 cites W1965033589 @default.
- W2903326024 cites W1976336399 @default.
- W2903326024 cites W1977709885 @default.
- W2903326024 cites W1982501876 @default.
- W2903326024 cites W1989595226 @default.
- W2903326024 cites W1996152427 @default.
- W2903326024 cites W1996612836 @default.
- W2903326024 cites W1997826161 @default.
- W2903326024 cites W1998384937 @default.
- W2903326024 cites W1998682759 @default.
- W2903326024 cites W1998719511 @default.
- W2903326024 cites W2000860796 @default.
- W2903326024 cites W2008688211 @default.
- W2903326024 cites W2011846912 @default.
- W2903326024 cites W2015218125 @default.
- W2903326024 cites W2020725477 @default.
- W2903326024 cites W2021728577 @default.
- W2903326024 cites W2023053172 @default.
- W2903326024 cites W2042652626 @default.
- W2903326024 cites W2044073767 @default.
- W2903326024 cites W2045893219 @default.
- W2903326024 cites W2052660293 @default.
- W2903326024 cites W2054014705 @default.
- W2903326024 cites W2059336743 @default.
- W2903326024 cites W2064815984 @default.
- W2903326024 cites W2068992647 @default.
- W2903326024 cites W2069633173 @default.
- W2903326024 cites W2073667659 @default.
- W2903326024 cites W2074727438 @default.
- W2903326024 cites W2080508595 @default.
- W2903326024 cites W2089441009 @default.
- W2903326024 cites W2091055429 @default.
- W2903326024 cites W2101293019 @default.
- W2903326024 cites W2120177943 @default.
- W2903326024 cites W2121550703 @default.
- W2903326024 cites W2129202635 @default.
- W2903326024 cites W2131970062 @default.
- W2903326024 cites W2135635187 @default.
- W2903326024 cites W2136331587 @default.
- W2903326024 cites W2137207158 @default.
- W2903326024 cites W2137885556 @default.
- W2903326024 cites W2139766250 @default.
- W2903326024 cites W2139890430 @default.
- W2903326024 cites W2141597250 @default.
- W2903326024 cites W2143628817 @default.
- W2903326024 cites W2144235090 @default.
- W2903326024 cites W2147086344 @default.
- W2903326024 cites W2152311269 @default.
- W2903326024 cites W2160662703 @default.
- W2903326024 cites W2162089651 @default.
- W2903326024 cites W2169276971 @default.
- W2903326024 cites W2170150986 @default.
- W2903326024 cites W2171613228 @default.
- W2903326024 cites W2190370833 @default.
- W2903326024 cites W2265009122 @default.
- W2903326024 cites W2293516780 @default.
- W2903326024 cites W2337088385 @default.
- W2903326024 cites W2417831971 @default.
- W2903326024 cites W2567439679 @default.
- W2903326024 cites W2589276620 @default.
- W2903326024 cites W2606913462 @default.
- W2903326024 cites W2653563074 @default.
- W2903326024 cites W2762054879 @default.
- W2903326024 cites W2884095185 @default.
- W2903326024 cites W305041615 @default.
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- W2903326024 doi "https://doi.org/10.1172/jci122595" @default.
- W2903326024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6307960" @default.
- W2903326024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30507612" @default.
- W2903326024 hasPublicationYear "2018" @default.
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