FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903332451> ?p ?o ?g. }

• W2903332451 endingPage "14" @default.
• W2903332451 startingPage "1" @default.
• W2903332451 abstract "Abstract DNA methylation is a regulatory mechanism in epigenetics that is frequently altered during human carcinogenesis. To detect critical methylation events associated with gastric cancer (GC), we compared three DNA methylomes from gastric mucosa (GM), intestinal metaplasia (IM), and gastric tumor (GT) cells that were microscopically dissected from an intestinal-type early gastric cancer (EGC) using methylated DNA binding domain sequencing (MBD-seq) and reduced representation bisulfite sequencing (RRBS) analysis. In this study, we focused on differentially methylated promoters (DMPs) that could be directly associated with gene expression. We detected 2,761 and 677 DMPs between the GT and GM by MBD-seq and RRBS, respectively, and for a total of 3,035 DMPs. Then, 514 (17%) of all DMPs were detected in the IM genome, which is a precancer of GC, supporting that some DMPs might represent an early event in gastric carcinogenesis. A pathway analysis of all DMPs demonstrated that 59 G protein-coupled receptor (GPCR) genes linked to the hypermethylated DMPs were significantly enriched in a neuroactive ligand–receptor interaction pathway. Furthermore, among the 59 GPCRs, six GI hormone receptor genes ( NPY1R , PPYR1 , PTGDR , PTGER2 , PTGER3 , and SSTR2 ) that play an inhibitory role in the secretion of gastrin or gastric acid were selected and validated as potential biomarkers for the diagnosis or prognosis of GC patients in two cohorts. These data suggest that the loss of function of gastrointestinal (GI) hormone receptors by promoter methylation may lead to gastric carcinogenesis because gastrin and gastric acid have been known to play a role in cell differentiation and carcinogenesis in the GI tract." @default.
• W2903332451 created "2018-12-11" @default.
• W2903332451 creator A5011116102 @default.
• W2903332451 creator A5025966040 @default.
• W2903332451 creator A5027841724 @default.
• W2903332451 creator A5033237694 @default.
• W2903332451 creator A5045574858 @default.
• W2903332451 creator A5046877370 @default.
• W2903332451 creator A5061875704 @default.
• W2903332451 creator A5084979248 @default.
• W2903332451 creator A5087350067 @default.
• W2903332451 creator A5088879960 @default.
• W2903332451 date "2018-12-01" @default.
• W2903332451 modified "2023-10-18" @default.
• W2903332451 title "Whole genome MBD-seq and RRBS analyses reveal that hypermethylation of gastrointestinal hormone receptors is associated with gastric carcinogenesis" @default.
• W2903332451 cites W1579447084 @default.
• W2903332451 cites W1814803903 @default.
• W2903332451 cites W1834156594 @default.
• W2903332451 cites W1929849064 @default.
• W2903332451 cites W1964451561 @default.
• W2903332451 cites W1964790941 @default.
• W2903332451 cites W1971617142 @default.
• W2903332451 cites W1976029788 @default.
• W2903332451 cites W1979585972 @default.
• W2903332451 cites W1998530387 @default.
• W2903332451 cites W2010461078 @default.
• W2903332451 cites W2011178667 @default.
• W2903332451 cites W2018546683 @default.
• W2903332451 cites W2029868343 @default.
• W2903332451 cites W2030049101 @default.
• W2903332451 cites W2037269030 @default.
• W2903332451 cites W2045807857 @default.
• W2903332451 cites W2052370666 @default.
• W2903332451 cites W2057388590 @default.
• W2903332451 cites W2060731557 @default.
• W2903332451 cites W2073136505 @default.
• W2903332451 cites W2080232093 @default.
• W2903332451 cites W2082514964 @default.
• W2903332451 cites W2093086547 @default.
• W2903332451 cites W2093203122 @default.
• W2903332451 cites W2108818515 @default.
• W2903332451 cites W2118699447 @default.
• W2903332451 cites W2123750815 @default.
• W2903332451 cites W2124059811 @default.
• W2903332451 cites W2126547130 @default.
• W2903332451 cites W2136342095 @default.
• W2903332451 cites W2137991416 @default.
• W2903332451 cites W2146237899 @default.
• W2903332451 cites W2148521032 @default.
• W2903332451 cites W2158217645 @default.
• W2903332451 cites W2158774461 @default.
• W2903332451 cites W2160504871 @default.
• W2903332451 cites W2161817637 @default.
• W2903332451 cites W2162229956 @default.
• W2903332451 cites W2163128444 @default.
• W2903332451 cites W2167665777 @default.
• W2903332451 cites W2257647775 @default.
• W2903332451 cites W2262529275 @default.
• W2903332451 cites W2338576041 @default.
• W2903332451 cites W2443232691 @default.
• W2903332451 cites W2521981506 @default.
• W2903332451 cites W4211231408 @default.
• W2903332451 cites W1993200218 @default.
• W2903332451 doi "https://doi.org/10.1038/s12276-018-0179-x" @default.
• W2903332451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6277407" @default.
• W2903332451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30510283" @default.
• W2903332451 hasPublicationYear "2018" @default.
• W2903332451 type Work @default.
• W2903332451 sameAs 2903332451 @default.
• W2903332451 citedByCount "13" @default.
• W2903332451 countsByYear W29033324512019 @default.
• W2903332451 countsByYear W29033324512020 @default.
• W2903332451 countsByYear W29033324512021 @default.
• W2903332451 countsByYear W29033324512022 @default.
• W2903332451 countsByYear W29033324512023 @default.
• W2903332451 crossrefType "journal-article" @default.
• W2903332451 hasAuthorship W2903332451A5011116102 @default.
• W2903332451 hasAuthorship W2903332451A5025966040 @default.
• W2903332451 hasAuthorship W2903332451A5027841724 @default.
• W2903332451 hasAuthorship W2903332451A5033237694 @default.
• W2903332451 hasAuthorship W2903332451A5045574858 @default.
• W2903332451 hasAuthorship W2903332451A5046877370 @default.
• W2903332451 hasAuthorship W2903332451A5061875704 @default.
• W2903332451 hasAuthorship W2903332451A5084979248 @default.
• W2903332451 hasAuthorship W2903332451A5087350067 @default.
• W2903332451 hasAuthorship W2903332451A5088879960 @default.
• W2903332451 hasBestOaLocation W29033324511 @default.
• W2903332451 hasConcept C104317684 @default.
• W2903332451 hasConcept C116114238 @default.
• W2903332451 hasConcept C121608353 @default.
• W2903332451 hasConcept C134018914 @default.
• W2903332451 hasConcept C150194340 @default.
• W2903332451 hasConcept C153911025 @default.
• W2903332451 hasConcept C190727270 @default.
• W2903332451 hasConcept C2776986829 @default.
• W2903332451 hasConcept C33288867 @default.
• W2903332451 hasConcept C41091548 @default.
• W2903332451 hasConcept C49039625 @default.

• next