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- W2903358295 abstract "Background/Aim: Most melanomas develop in hypoxic conditions. Since hypoxia via HIF-1 induces glycolysis, a process essential for malignant melanoma growth/survival, the goal of this study was to analyze the influence of hypoxia on the expression of HIF-1 target genes involved in glucose metabolism. Materials and Methods: The response of melanoma cell lines to hypoxic conditions was analyzed by RT-PCR and western blotting. A Kaplan–Meier survival analysis for patients with high and low expression level of PFKFB4 was performed. Further analysis of patients9 data was performed using the R/Bioconductor environment. Results: Induction of PFKFB4 gene expression can be considered a crucial mechanism behind glycolysis enhancement in hypoxic melanoma cells. Analysis of a publicly available database revealed that high PFKFB4 expression contributes to poor prognosis of melanoma patients. Conclusion: Currently available anti-melanoma therapeutic strategies may significantly benefit from agents targeting PFKFB4 activity." @default.
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- W2903358295 date "2018-11-30" @default.
- W2903358295 modified "2023-10-12" @default.
- W2903358295 title "Analysis of Malignant Melanoma Cell Lines Exposed to Hypoxia Reveals the Importance of <i>PFKFB4</i> Overexpression for Disease Progression" @default.
- W2903358295 doi "https://doi.org/10.21873/anticanres.13044" @default.
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