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- W2903378618 abstract "The big conductance Ca 2+ -dependent K + channel, also known as BK, MaxiK, Slo1, or KCa1.1, is a ligand- and voltage-gated K + channel. Although structure-function studies of the past decades, involving mutagenesis and electrophysiological measurements, revealed fine details of the mechanism of BK channel gating, the exact molecular details remained unknown until the quaternary structure of the protein has been solved at a resolution of 3.5 Å using cryo-electron microscopy. In this short review, we are going to summarize these results and interpret the gating model of the BK channel in the light of the recent structural results." @default.
- W2903378618 created "2018-12-11" @default.
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- W2903378618 date "2019-06-01" @default.
- W2903378618 modified "2023-10-18" @default.
- W2903378618 title "Brief structural insight into the allosteric gating mechanism of BK (Slo1) channel" @default.
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- W2903378618 doi "https://doi.org/10.1139/cjpp-2018-0516" @default.
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