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• W2903397549 abstract "Aster incisus is a common flower found in almost all regions of South Korea. In the current study, we investigated the potential antioxidant and anti-inflammatory properties of the Aster incisus methanol extract in LPS-stimulated RAW 264.7 cells. We analyzed the phytochemicals contained in the extract by GC-MS. GC-MS results showed that the Aster incisus extract contains 9 known compounds. Later on, DPPH assay, WST-1 assay, nitric oxide (NO) assay, Western blot, and RT-PCR were conducted to investigate the anti-inflammatory effects of the extract. Our WST-1 assay results revealed that Aster incisus did not affect the viability of all tested cell lines up to a concentration of 200 μ g/ml; therefore, lower concentrations (50 μ g/ml and 150 μ g/ml) were used for further assays. Aster incisus scavenged DPPH and inhibited the production of NO. Aster incisus also reduced significantly the production of inflammation-related enzymes (iNOS, Cox-2) and cytokines (TNF α , IL-1 β , and IL-6) and the gene expression of the proinflammatory cytokines. Additionally, further Western blot results indicated that Aster incisus inhibited the expression of p-PI3K, p-I κ B α , p-p65 NF- κ B, p-ERK1/2, p-SAPK/JNK, and p-Akt. Our results demonstrated that Aster incisus suppressed the expression of the inflammation mediators through the regulation of NF- κ B, MAPK, and Akt pathways." @default.
• W2903397549 created "2018-12-11" @default.
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• W2903397549 date "2018-11-29" @default.
• W2903397549 modified "2023-10-17" @default.
• W2903397549 title "Anti-Inflammatory Effects of <i>Aster incisus</i> through the Inhibition of NF-<i>κ</i>B, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages" @default.
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• W2903397549 doi "https://doi.org/10.1155/2018/4675204" @default.
• W2903397549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6304821" @default.
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