Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903400269> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2903400269 endingPage "205" @default.
- W2903400269 startingPage "199" @default.
- W2903400269 abstract "The substitution rates of viral polymerases have been studied extensively. However less is known about the tendency of these enzymes to 'slip' during RNA synthesis to produce progeny RNAs with nucleotide insertions or deletions. We recently described the functional utilization of programmed polymerase slippage in the family Potyviridae. This slippage results in either an insertion or a substitution, depending on whether the RNA duplex realigns following the insertion. In this study we investigated whether this phenomenon is a conserved feature of superfamily I viral RdRps, by inserting a range of potyvirus-derived slip-prone sequences into a picornavirus, Theiler's murine encephalomyelitis virus (TMEV). Deep-sequencing analysis of viral transcripts indicates that the TMEV polymerase 'slips' at the sequences U6-7 and A6-7 to insert additional nucleotides. Such sequences are under-represented within picornaviral genomes, suggesting that slip-prone sequences create a fitness cost. Nonetheless, the TMEV insertional and substitutional spectrum differed from that previously determined for the potyvirus polymerase." @default.
- W2903400269 created "2018-12-11" @default.
- W2903400269 creator A5007404143 @default.
- W2903400269 creator A5035399549 @default.
- W2903400269 creator A5057018655 @default.
- W2903400269 creator A5084663192 @default.
- W2903400269 date "2019-02-01" @default.
- W2903400269 modified "2023-10-16" @default.
- W2903400269 title "Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites" @default.
- W2903400269 cites W1822236674 @default.
- W2903400269 cites W1925735392 @default.
- W2903400269 cites W1926826741 @default.
- W2903400269 cites W1978439509 @default.
- W2903400269 cites W1978996068 @default.
- W2903400269 cites W1986496785 @default.
- W2903400269 cites W1996952582 @default.
- W2903400269 cites W2002167317 @default.
- W2903400269 cites W2017990250 @default.
- W2903400269 cites W2034764834 @default.
- W2903400269 cites W2039332401 @default.
- W2903400269 cites W2045000874 @default.
- W2903400269 cites W2088925462 @default.
- W2903400269 cites W2089811119 @default.
- W2903400269 cites W2111729216 @default.
- W2903400269 cites W2121255902 @default.
- W2903400269 cites W2124369168 @default.
- W2903400269 cites W2133623408 @default.
- W2903400269 cites W2134017678 @default.
- W2903400269 cites W2331356471 @default.
- W2903400269 cites W2401460553 @default.
- W2903400269 cites W2405361759 @default.
- W2903400269 cites W2411780855 @default.
- W2903400269 doi "https://doi.org/10.1099/jgv.0.001189" @default.
- W2903400269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6591135" @default.
- W2903400269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30507373" @default.
- W2903400269 hasPublicationYear "2019" @default.
- W2903400269 type Work @default.
- W2903400269 sameAs 2903400269 @default.
- W2903400269 citedByCount "4" @default.
- W2903400269 countsByYear W29034002692021 @default.
- W2903400269 countsByYear W29034002692022 @default.
- W2903400269 countsByYear W29034002692023 @default.
- W2903400269 crossrefType "journal-article" @default.
- W2903400269 hasAuthorship W2903400269A5007404143 @default.
- W2903400269 hasAuthorship W2903400269A5035399549 @default.
- W2903400269 hasAuthorship W2903400269A5057018655 @default.
- W2903400269 hasAuthorship W2903400269A5084663192 @default.
- W2903400269 hasBestOaLocation W29034002691 @default.
- W2903400269 hasConcept C104317684 @default.
- W2903400269 hasConcept C109110057 @default.
- W2903400269 hasConcept C159047783 @default.
- W2903400269 hasConcept C2522874641 @default.
- W2903400269 hasConcept C2776449523 @default.
- W2903400269 hasConcept C2776625791 @default.
- W2903400269 hasConcept C2778009244 @default.
- W2903400269 hasConcept C2910353488 @default.
- W2903400269 hasConcept C54355233 @default.
- W2903400269 hasConcept C67705224 @default.
- W2903400269 hasConcept C82381507 @default.
- W2903400269 hasConcept C86803240 @default.
- W2903400269 hasConceptScore W2903400269C104317684 @default.
- W2903400269 hasConceptScore W2903400269C109110057 @default.
- W2903400269 hasConceptScore W2903400269C159047783 @default.
- W2903400269 hasConceptScore W2903400269C2522874641 @default.
- W2903400269 hasConceptScore W2903400269C2776449523 @default.
- W2903400269 hasConceptScore W2903400269C2776625791 @default.
- W2903400269 hasConceptScore W2903400269C2778009244 @default.
- W2903400269 hasConceptScore W2903400269C2910353488 @default.
- W2903400269 hasConceptScore W2903400269C54355233 @default.
- W2903400269 hasConceptScore W2903400269C67705224 @default.
- W2903400269 hasConceptScore W2903400269C82381507 @default.
- W2903400269 hasConceptScore W2903400269C86803240 @default.
- W2903400269 hasIssue "2" @default.
- W2903400269 hasLocation W29034002691 @default.
- W2903400269 hasLocation W29034002692 @default.
- W2903400269 hasLocation W29034002693 @default.
- W2903400269 hasLocation W29034002694 @default.
- W2903400269 hasLocation W29034002695 @default.
- W2903400269 hasOpenAccess W2903400269 @default.
- W2903400269 hasPrimaryLocation W29034002691 @default.
- W2903400269 hasRelatedWork W11958539 @default.
- W2903400269 hasRelatedWork W1243114843 @default.
- W2903400269 hasRelatedWork W1558257800 @default.
- W2903400269 hasRelatedWork W1966659060 @default.
- W2903400269 hasRelatedWork W1983008158 @default.
- W2903400269 hasRelatedWork W2141097630 @default.
- W2903400269 hasRelatedWork W2903400269 @default.
- W2903400269 hasRelatedWork W2939498534 @default.
- W2903400269 hasRelatedWork W4211202432 @default.
- W2903400269 hasRelatedWork W92017478 @default.
- W2903400269 hasVolume "100" @default.
- W2903400269 isParatext "false" @default.
- W2903400269 isRetracted "false" @default.
- W2903400269 magId "2903400269" @default.
- W2903400269 workType "article" @default.