FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903404807> ?p ?o ?g. }

• W2903404807 abstract "Abstract Small interfering ribonucleic acid (siRNA)‐based gene knockdown is an effective tool for gene screening and therapeutics. However, the use of nonviral methods has remained an enormous challenge in neural cells. A strategy is reported to design artificial noncationic modular peptides with amplified affinity for siRNA via supramolecular assembly that shows efficient protein knockdown in neural cells. By solid phase synthesis, a sequence that binds specifically double‐stranded ribonucleic acid (dsRNA) with a self‐assembling peptide for particle formation is integrated. These supramolecular particles can be further functionalized with bioactive sequences without affecting their biophysical properties. The peptide carrier is found to silence efficiently up to 83% of protein expression in primary astroglial and neuronal cell cultures without cytotoxicity. In the case of neurons, a reduction in electrical activity is observed once the presynaptic protein synaptophysin is downregulated by the siRNA–peptide particles. The results demonstrate that the supramolecular particles offer an siRNA delivery platform for efficient nonviral gene screening and discovery of novel therapies for neural cells." @default.
• W2903404807 created "2018-12-11" @default.
• W2903404807 creator A5001027248 @default.
• W2903404807 creator A5004275360 @default.
• W2903404807 creator A5022237626 @default.
• W2903404807 creator A5043776462 @default.
• W2903404807 creator A5053784160 @default.
• W2903404807 creator A5057679210 @default.
• W2903404807 creator A5079222349 @default.
• W2903404807 creator A5080354885 @default.
• W2903404807 creator A5081484164 @default.
• W2903404807 creator A5083038967 @default.
• W2903404807 date "2018-12-05" @default.
• W2903404807 modified "2023-10-16" @default.
• W2903404807 title "Peptide–siRNA Supramolecular Particles for Neural Cell Transfection" @default.
• W2903404807 cites W1843302206 @default.
• W2903404807 cites W1971213127 @default.
• W2903404807 cites W1981298152 @default.
• W2903404807 cites W1984711580 @default.
• W2903404807 cites W1993501781 @default.
• W2903404807 cites W1995770815 @default.
• W2903404807 cites W2007304383 @default.
• W2903404807 cites W2015855486 @default.
• W2903404807 cites W2025971310 @default.
• W2903404807 cites W2027417866 @default.
• W2903404807 cites W2027876233 @default.
• W2903404807 cites W2029842408 @default.
• W2903404807 cites W2033212918 @default.
• W2903404807 cites W2070280888 @default.
• W2903404807 cites W2070693578 @default.
• W2903404807 cites W2076752324 @default.
• W2903404807 cites W2077102218 @default.
• W2903404807 cites W2091579099 @default.
• W2903404807 cites W2113811929 @default.
• W2903404807 cites W2117522169 @default.
• W2903404807 cites W2120820989 @default.
• W2903404807 cites W2136916247 @default.
• W2903404807 cites W2171260527 @default.
• W2903404807 cites W2282615244 @default.
• W2903404807 cites W2903404807 @default.
• W2903404807 doi "https://doi.org/10.1002/advs.201801458" @default.
• W2903404807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6364495" @default.
• W2903404807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30775231" @default.
• W2903404807 hasPublicationYear "2018" @default.
• W2903404807 type Work @default.
• W2903404807 sameAs 2903404807 @default.
• W2903404807 citedByCount "9" @default.
• W2903404807 countsByYear W29034048072020 @default.
• W2903404807 countsByYear W29034048072021 @default.
• W2903404807 countsByYear W29034048072023 @default.
• W2903404807 crossrefType "journal-article" @default.
• W2903404807 hasAuthorship W2903404807A5001027248 @default.
• W2903404807 hasAuthorship W2903404807A5004275360 @default.
• W2903404807 hasAuthorship W2903404807A5022237626 @default.
• W2903404807 hasAuthorship W2903404807A5043776462 @default.
• W2903404807 hasAuthorship W2903404807A5053784160 @default.
• W2903404807 hasAuthorship W2903404807A5057679210 @default.
• W2903404807 hasAuthorship W2903404807A5079222349 @default.
• W2903404807 hasAuthorship W2903404807A5080354885 @default.
• W2903404807 hasAuthorship W2903404807A5081484164 @default.
• W2903404807 hasAuthorship W2903404807A5083038967 @default.
• W2903404807 hasBestOaLocation W29034048071 @default.
• W2903404807 hasConcept C104317684 @default.
• W2903404807 hasConcept C115624301 @default.
• W2903404807 hasConcept C119056186 @default.
• W2903404807 hasConcept C1491633281 @default.
• W2903404807 hasConcept C153911025 @default.
• W2903404807 hasConcept C166703698 @default.
• W2903404807 hasConcept C173396325 @default.
• W2903404807 hasConcept C185592680 @default.
• W2903404807 hasConcept C22615655 @default.
• W2903404807 hasConcept C2779281246 @default.
• W2903404807 hasConcept C2992459734 @default.
• W2903404807 hasConcept C54009773 @default.
• W2903404807 hasConcept C55493867 @default.
• W2903404807 hasConcept C67705224 @default.
• W2903404807 hasConcept C8010536 @default.
• W2903404807 hasConcept C86803240 @default.
• W2903404807 hasConcept C93275456 @default.
• W2903404807 hasConcept C95444343 @default.
• W2903404807 hasConceptScore W2903404807C104317684 @default.
• W2903404807 hasConceptScore W2903404807C115624301 @default.
• W2903404807 hasConceptScore W2903404807C119056186 @default.
• W2903404807 hasConceptScore W2903404807C1491633281 @default.
• W2903404807 hasConceptScore W2903404807C153911025 @default.
• W2903404807 hasConceptScore W2903404807C166703698 @default.
• W2903404807 hasConceptScore W2903404807C173396325 @default.
• W2903404807 hasConceptScore W2903404807C185592680 @default.
• W2903404807 hasConceptScore W2903404807C22615655 @default.
• W2903404807 hasConceptScore W2903404807C2779281246 @default.
• W2903404807 hasConceptScore W2903404807C2992459734 @default.
• W2903404807 hasConceptScore W2903404807C54009773 @default.
• W2903404807 hasConceptScore W2903404807C55493867 @default.
• W2903404807 hasConceptScore W2903404807C67705224 @default.
• W2903404807 hasConceptScore W2903404807C8010536 @default.
• W2903404807 hasConceptScore W2903404807C86803240 @default.
• W2903404807 hasConceptScore W2903404807C93275456 @default.
• W2903404807 hasConceptScore W2903404807C95444343 @default.
• W2903404807 hasFunder F4320306148 @default.
• W2903404807 hasFunder F4320308306 @default.

• next