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• W2903447153 abstract "Three new manganese complexes trans-[Mn(P–NH–NH–P)(CO)2][Br], (14) P–NH–NH–P = (S,S)-PPh2CH2CH2NH–CHPhCHPhNHCH2CH2PPh2), fac-[Mn(P′–NH–NH2)(CO)3][Br], (15) P′–NH–NH2 = (S,S)-PPh2(C6H4)NHCHPhCHPhNH2, and syn-mer-Mn(P–NH–NH2)(CO)2Br, (16) P–NH–NH2 = (S,S)-PPh2CH2CH2NHCHPhCHPhNH2 were synthesized and tested for the asymmetric transfer hydrogenation (ATH) of acetophenone in 2-PrOH. The ligands have stereogenic centers derived from the starting diamine, (S,S)-DPEN. Complex 16 was shown by NOE NMR experiments to have Mn–Br syn to the N–H of the secondary amine. Only the precatalyst 16, upon reaction with potassium tert-butoxide (KOtBu) in 2-PrOH, generated an active system at 80 °C for the ATH of acetophenone to 1-phenylethanol in an enantiomeric excess (ee) of 42% and thus was selected for further investigation into the mechanism of transfer hydrogenation. The corresponding amido complex Mn(P–N–NH2)(CO)2 (17), a borohydride complex syn-mer-Mn(P–NH–NH2)(CO)2(BH4) (18), and an ethoxide complex anti-mer-Mn(P–NH–NH2)(CO)2(OEt) (19′) were independently synthesized and tested in the ATH of acetophenone. The amido complex 17 and the borohydride complex 18 displayed similar activity to 16 activated in basic 2-PrOH, but the anti NH OEt complex 19′ was completely inactive. This result suggested that the NH effect, as described by Noyori, was required to obtain catalytic activity. The syn NH BH4 manganese complex is one of the most active manganese ATH catalysts to date and can hydrogenate a variety of aromatic ketones, including base-sensitive substrates such as p-acetylbenzoate ethyl ester." @default.
• W2903447153 created "2018-12-11" @default.
• W2903447153 creator A5027788433 @default.
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• W2903447153 date "2018-12-05" @default.
• W2903447153 modified "2023-10-01" @default.
• W2903447153 title "Asymmetric Transfer Hydrogenation of Ketones with Well-Defined Manganese(I) PNN and PNNP Complexes" @default.
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• W2903447153 doi "https://doi.org/10.1021/acs.organomet.8b00625" @default.
• W2903447153 hasPublicationYear "2018" @default.
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