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- W2903468637 abstract "INTRODUCTION:Preeclampsia is pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 weeks of gestation. It is a leading cause of maternal and foetal mortality and morbidity. Preeclampsia affects 3-5% of all the pregnancies. Soluble fms like tyrosine kinase 1, an anti angiogenic factor is involved in vasoconstriction and endothelial dysfunction responsible for the development of preeclampsia.AIM & OBJECTIVES:PRIMARY OBJECTIVE:To find the association between soluble fms like tyrosine kinase 1 and incidence of preeclampsia in primi gravida.SECONDARY OBJECTIVE:1. To determine the predictive value of soluble fms like tyrosine kinase 1 for preeclampsia.2. To determine whether early screening can be done for preeclampsia using soluble fms like tyrosine kinase 1.MATERIALS AND METHODS:This is a prospective study conducted in Thanjavur medical college hospital and allied institutions. Blood and urine samples were collected from primigravida patientsattending department of Obstetrics and Gynecology, TMCH/RMH and analyzed for soluble fms like tyrosine kinase 1, liver enzymes , platelet count and urine for protein.Soluble fms like tyrosine kinase 1 is estimated by sandwich elisa method.INCLUSION CRITERIA:All Primi Gravida pateints attending department of Obstetrics and Gynecology, TMCH/RMH.EXCLUSION CRITERIA:Known cases of Diabetic, Hypertensive and Hepatic disease,Known patients with proteinuria, Known patients with other organ dysfunction.DISCUSSION:Increase in placental derived soluble fms-like tyrosine kinase 1 (sFlt-1) is responsible for the signs and symptoms of Preeclampsia, and increased levels of these circulatingmarkers are associated with Preeclampsia. In our study, we focused only on primigravida, because nulliparity itself is a main risk factor for the development of Preeclampsia. If we look into distribution of study population according to Preeclampsia and SFLT levels through Pearson’s Chi-square with continuity correction (69.348, p value: < 0.001), there is a statistically significant association between elevated SFLT levels and occurrence of Preeclampsia with 86.4% of Pre-eclampsia & Eclampsia patients showing elevated SFLT levels.CONCLUSION:From this study, It is found that the primigravida with increased serum sFlt levels developed Preeclampsia in the later pregnancy and few of them developed Eclampsia also. So, serum sFlt levels can be used to predict the occurrence of both Preeclampsia and also progression to Eclampsia." @default.
- W2903468637 created "2018-12-11" @default.
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- W2903468637 date "2016-04-01" @default.
- W2903468637 modified "2023-09-27" @default.
- W2903468637 title "A study of Soluble FMS like Tyrosine Kinase 1 as predictive marker of preeclampsia in primigravida" @default.
- W2903468637 hasPublicationYear "2016" @default.
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