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- W2903476670 endingPage "8533" @default.
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- W2903476670 abstract "Intermediary metabolites have a crucial impact on basic cell functions. There is a relationship between cellular metabolism and redox balance. To maintain redox homoeostasis, the cooperation of both glutathione and nicotine adenine dinucleotides is necessary. Availability of nicotinamide adenine dinucleotide phosphate (NADPH) as a major electron donor is critical for many intracellular redox reactions. The activity of glucose-6-phosphate dehydrogenase (Zwf1p) and 6-phosphogluconate dehydrogenase (Gnd1p and Gnd2p) is responsible for NADPH formation in a pentose phosphate (PP) pathway. In this study, we examine the impact of redox homoeostasis on cellular physiology and proliferation. We have noted that the Δzwf1 mutant lacking the rate-limiting enzyme of the PP pathway shows changes in the cellular redox status caused by disorders in NADPH generation. This leads to a decrease in reproductive potential but without affecting the total lifespan of the cell. The results presented in this paper show that nicotine adenine dinucleotides play a central role in cellular physiology." @default.
- W2903476670 created "2018-12-11" @default.
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- W2903476670 date "2018-11-26" @default.
- W2903476670 modified "2023-09-30" @default.
- W2903476670 title "Disorders in NADPH generation via pentose phosphate pathway influence the reproductive potential of the <i>Saccharomyces cerevisiae</i> yeast due to changes in redox status" @default.
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- W2903476670 doi "https://doi.org/10.1002/jcb.28140" @default.
- W2903476670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30474881" @default.
- W2903476670 hasPublicationYear "2018" @default.
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