Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903476952> ?p ?o ?g. }
- W2903476952 endingPage "12559" @default.
- W2903476952 startingPage "12552" @default.
- W2903476952 abstract "Abstract Metal complexes of cyclen have been widely used to hydrolytically cleave biomolecules (proteins, RNA, DNA) and model substrates. Such cleavage reactions, however, usually require a high pH, long incubation times and enhanced temperatures. The present study combines two straightforward approaches to increase the proteolytic cleavage activity of cyclen complexes: alkylation in order to improve interactions with hydrophobic domains of proteins as well as single and double heteroatom exchange in order to increase the Lewis acidity of the metal center, in this case Cu(II). This allows reactions with BSA and Mb as model proteins to be carried out also at near‐physiological conditions. A Cu(II) complex with an alkylated oxacyclen ligand was identified as the most efficient species. Furthermore, a dioxacyclen derivative was investigated in proteolytic reactions for the first time." @default.
- W2903476952 created "2018-12-11" @default.
- W2903476952 creator A5006006016 @default.
- W2903476952 creator A5012817941 @default.
- W2903476952 creator A5054618761 @default.
- W2903476952 creator A5066810528 @default.
- W2903476952 date "2018-11-28" @default.
- W2903476952 modified "2023-09-26" @default.
- W2903476952 title "Monoalkylated Cyclen Complexes for Efficient Proteolysis: Influence of Donor Atom Exchange" @default.
- W2903476952 cites W1529662354 @default.
- W2903476952 cites W1948147649 @default.
- W2903476952 cites W1967769136 @default.
- W2903476952 cites W1973529607 @default.
- W2903476952 cites W1982301456 @default.
- W2903476952 cites W1983724195 @default.
- W2903476952 cites W1984622104 @default.
- W2903476952 cites W1988035495 @default.
- W2903476952 cites W1993362148 @default.
- W2903476952 cites W1994492355 @default.
- W2903476952 cites W2002131961 @default.
- W2903476952 cites W2002789164 @default.
- W2903476952 cites W2002879674 @default.
- W2903476952 cites W2009089889 @default.
- W2903476952 cites W2010130751 @default.
- W2903476952 cites W2023717139 @default.
- W2903476952 cites W2026075478 @default.
- W2903476952 cites W2030347038 @default.
- W2903476952 cites W2035633552 @default.
- W2903476952 cites W2049989814 @default.
- W2903476952 cites W2052878632 @default.
- W2903476952 cites W2055155126 @default.
- W2903476952 cites W2055743601 @default.
- W2903476952 cites W2056329905 @default.
- W2903476952 cites W2058889725 @default.
- W2903476952 cites W2059020082 @default.
- W2903476952 cites W2059679350 @default.
- W2903476952 cites W2069647154 @default.
- W2903476952 cites W2076047582 @default.
- W2903476952 cites W2086740942 @default.
- W2903476952 cites W2089189640 @default.
- W2903476952 cites W2090806875 @default.
- W2903476952 cites W2100837269 @default.
- W2903476952 cites W2112750511 @default.
- W2903476952 cites W2127804664 @default.
- W2903476952 cites W2131502462 @default.
- W2903476952 cites W2132889599 @default.
- W2903476952 cites W2170889355 @default.
- W2903476952 cites W2314979608 @default.
- W2903476952 cites W2417747227 @default.
- W2903476952 cites W2952362669 @default.
- W2903476952 cites W2953341981 @default.
- W2903476952 doi "https://doi.org/10.1002/slct.201800944" @default.
- W2903476952 hasPublicationYear "2018" @default.
- W2903476952 type Work @default.
- W2903476952 sameAs 2903476952 @default.
- W2903476952 citedByCount "1" @default.
- W2903476952 countsByYear W29034769522019 @default.
- W2903476952 crossrefType "journal-article" @default.
- W2903476952 hasAuthorship W2903476952A5006006016 @default.
- W2903476952 hasAuthorship W2903476952A5012817941 @default.
- W2903476952 hasAuthorship W2903476952A5054618761 @default.
- W2903476952 hasAuthorship W2903476952A5066810528 @default.
- W2903476952 hasConcept C116569031 @default.
- W2903476952 hasConcept C127413603 @default.
- W2903476952 hasConcept C161790260 @default.
- W2903476952 hasConcept C164361826 @default.
- W2903476952 hasConcept C170493617 @default.
- W2903476952 hasConcept C175156509 @default.
- W2903476952 hasConcept C178790620 @default.
- W2903476952 hasConcept C181199279 @default.
- W2903476952 hasConcept C185592680 @default.
- W2903476952 hasConcept C187320778 @default.
- W2903476952 hasConcept C19014433 @default.
- W2903476952 hasConcept C20950531 @default.
- W2903476952 hasConcept C21951064 @default.
- W2903476952 hasConcept C2777459166 @default.
- W2903476952 hasConcept C2780378348 @default.
- W2903476952 hasConcept C2781307694 @default.
- W2903476952 hasConcept C43369102 @default.
- W2903476952 hasConcept C49853544 @default.
- W2903476952 hasConcept C544153396 @default.
- W2903476952 hasConcept C55493867 @default.
- W2903476952 hasConcept C71240020 @default.
- W2903476952 hasConceptScore W2903476952C116569031 @default.
- W2903476952 hasConceptScore W2903476952C127413603 @default.
- W2903476952 hasConceptScore W2903476952C161790260 @default.
- W2903476952 hasConceptScore W2903476952C164361826 @default.
- W2903476952 hasConceptScore W2903476952C170493617 @default.
- W2903476952 hasConceptScore W2903476952C175156509 @default.
- W2903476952 hasConceptScore W2903476952C178790620 @default.
- W2903476952 hasConceptScore W2903476952C181199279 @default.
- W2903476952 hasConceptScore W2903476952C185592680 @default.
- W2903476952 hasConceptScore W2903476952C187320778 @default.
- W2903476952 hasConceptScore W2903476952C19014433 @default.
- W2903476952 hasConceptScore W2903476952C20950531 @default.
- W2903476952 hasConceptScore W2903476952C21951064 @default.
- W2903476952 hasConceptScore W2903476952C2777459166 @default.
- W2903476952 hasConceptScore W2903476952C2780378348 @default.