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• W2903488796 abstract "Antigen 16 (CD19) is an optimal target for targeted cellular therapy against all B-cell non-Hodgkin lymphomas (B-NHL)/chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and B-cell acute lymphoblastic leukemia (B-ALL). However, targeting CD19 can result in prolonged B-cell aplasia. Given the clinical experience with the anti-CD20 monoclonal antibody rituximab with temporary B-cell aplasia, severe clinical consequence has not been observed. Intravenous gamma globulin has proven to effectively supplement humoral immunity in hypogammaglobulinemic patients. Genetically engineered recombinant T-cell receptors directed against a specific tumor antigen (chimeric antigen receptors, CARs) can recognize and kill tumor cell targets. This review will focus on the clinical experience of targeting CD19 with CAR-modified T cells (19-CAR-T) for B-cell lymphomas, excluding CLL/SLL and multiple myeloma which are covered in other chapters of this book." @default.
• W2903488796 created "2018-12-11" @default.
• W2903488796 creator A5034628611 @default.
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• W2903488796 date "2018-11-28" @default.
• W2903488796 modified "2023-10-16" @default.
• W2903488796 title "Chimeric Antigen Receptor T Cells for Lymphomas: Methods, Data, and Challenges" @default.
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• W2903488796 doi "https://doi.org/10.1007/978-3-319-54368-0_6" @default.
• W2903488796 hasPublicationYear "2018" @default.
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