FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903504014> ?p ?o ?g. }

• W2903504014 endingPage "1256" @default.
• W2903504014 startingPage "1250" @default.
• W2903504014 abstract "Venomous snakes have endogenous proteins that neutralize the toxicity of their venom components. We previously identified five small serum proteins (SSP-1-SSP-5) from a highly venomous snake belonging to the family Viperidae as inhibitors of various toxins from snake venom. The endogenous inhibitors belong to the prostate secretory protein of 94 amino acids (PSP94) family. SSP-2 interacts with triflin, which is a member of the cysteine-rich secretory protein (CRISP) family that blocks smooth muscle contraction. However, the structural basis for the interaction and the biological roles of these inhibitors are largely unknown. Here, we determined the crystal structure of the SSP-2-triflin complex at 2.3 Å resolution. A concave region centrally located in the N-terminal domain of triflin is fully occupied by the terminal β-strands of SSP-2. SSP-2 does not bind tightly to the C-terminal cysteine-rich domain of triflin; this domain is thought to be responsible for its channel-blocker function. Instead, the cysteine-rich domain is tilted 7.7° upon binding to SSP-2, and the inhibitor appears to sterically hinder triflin binding to calcium channels. These results help explain how an endogenous inhibitor prevents the venomous protein from maintaining homeostasis in the host. Furthermore, this interaction also sheds light on the binding interface between the human homologues PSP94 and CRISP-3, which are up-regulated in prostate and ovarian cancers." @default.
• W2903504014 created "2018-12-11" @default.
• W2903504014 creator A5005161958 @default.
• W2903504014 creator A5012401478 @default.
• W2903504014 creator A5023168058 @default.
• W2903504014 creator A5030511788 @default.
• W2903504014 creator A5042597121 @default.
• W2903504014 creator A5046296830 @default.
• W2903504014 creator A5064277838 @default.
• W2903504014 creator A5065748566 @default.
• W2903504014 creator A5069517444 @default.
• W2903504014 creator A5085189861 @default.
• W2903504014 date "2019-01-01" @default.
• W2903504014 modified "2023-10-16" @default.
• W2903504014 title "Crystal structure of the complex between venom toxin and serum inhibitor from Viperidae snake" @default.
• W2903504014 cites W1522825458 @default.
• W2903504014 cites W1539796472 @default.
• W2903504014 cites W1801249858 @default.
• W2903504014 cites W1871924278 @default.
• W2903504014 cites W1932417500 @default.
• W2903504014 cites W1965760623 @default.
• W2903504014 cites W1966432727 @default.
• W2903504014 cites W1969672293 @default.
• W2903504014 cites W1970757301 @default.
• W2903504014 cites W1978751114 @default.
• W2903504014 cites W1978774979 @default.
• W2903504014 cites W1980338102 @default.
• W2903504014 cites W1980835782 @default.
• W2903504014 cites W1987164523 @default.
• W2903504014 cites W2007413963 @default.
• W2903504014 cites W2011374678 @default.
• W2903504014 cites W2016381427 @default.
• W2903504014 cites W2030116431 @default.
• W2903504014 cites W2034318405 @default.
• W2903504014 cites W2035503835 @default.
• W2903504014 cites W2038840577 @default.
• W2903504014 cites W2058146153 @default.
• W2903504014 cites W2072281435 @default.
• W2903504014 cites W2075770210 @default.
• W2903504014 cites W2076280242 @default.
• W2903504014 cites W2087791127 @default.
• W2903504014 cites W2097493124 @default.
• W2903504014 cites W2109993406 @default.
• W2903504014 cites W2117250036 @default.
• W2903504014 cites W2117673203 @default.
• W2903504014 cites W2144081223 @default.
• W2903504014 cites W2150469567 @default.
• W2903504014 cites W2154714625 @default.
• W2903504014 cites W2180229411 @default.
• W2903504014 cites W2584528756 @default.
• W2903504014 doi "https://doi.org/10.1074/jbc.ra118.006840" @default.
• W2903504014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6349104" @default.
• W2903504014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30504218" @default.
• W2903504014 hasPublicationYear "2019" @default.
• W2903504014 type Work @default.
• W2903504014 sameAs 2903504014 @default.
• W2903504014 citedByCount "10" @default.
• W2903504014 countsByYear W29035040142019 @default.
• W2903504014 countsByYear W29035040142020 @default.
• W2903504014 countsByYear W29035040142021 @default.
• W2903504014 countsByYear W29035040142022 @default.
• W2903504014 crossrefType "journal-article" @default.
• W2903504014 hasAuthorship W2903504014A5005161958 @default.
• W2903504014 hasAuthorship W2903504014A5012401478 @default.
• W2903504014 hasAuthorship W2903504014A5023168058 @default.
• W2903504014 hasAuthorship W2903504014A5030511788 @default.
• W2903504014 hasAuthorship W2903504014A5042597121 @default.
• W2903504014 hasAuthorship W2903504014A5046296830 @default.
• W2903504014 hasAuthorship W2903504014A5064277838 @default.
• W2903504014 hasAuthorship W2903504014A5065748566 @default.
• W2903504014 hasAuthorship W2903504014A5069517444 @default.
• W2903504014 hasAuthorship W2903504014A5085189861 @default.
• W2903504014 hasBestOaLocation W29035040141 @default.
• W2903504014 hasConcept C104317684 @default.
• W2903504014 hasConcept C144292202 @default.
• W2903504014 hasConcept C16613235 @default.
• W2903504014 hasConcept C167625842 @default.
• W2903504014 hasConcept C181199279 @default.
• W2903504014 hasConcept C2776725428 @default.
• W2903504014 hasConcept C2777367657 @default.
• W2903504014 hasConcept C2779201268 @default.
• W2903504014 hasConcept C2779231127 @default.
• W2903504014 hasConcept C2779448229 @default.
• W2903504014 hasConcept C2780331750 @default.
• W2903504014 hasConcept C47701112 @default.
• W2903504014 hasConcept C55493867 @default.
• W2903504014 hasConcept C86803240 @default.
• W2903504014 hasConceptScore W2903504014C104317684 @default.
• W2903504014 hasConceptScore W2903504014C144292202 @default.
• W2903504014 hasConceptScore W2903504014C16613235 @default.
• W2903504014 hasConceptScore W2903504014C167625842 @default.
• W2903504014 hasConceptScore W2903504014C181199279 @default.
• W2903504014 hasConceptScore W2903504014C2776725428 @default.
• W2903504014 hasConceptScore W2903504014C2777367657 @default.
• W2903504014 hasConceptScore W2903504014C2779201268 @default.
• W2903504014 hasConceptScore W2903504014C2779231127 @default.
• W2903504014 hasConceptScore W2903504014C2779448229 @default.
• W2903504014 hasConceptScore W2903504014C2780331750 @default.

• next