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- W2903513170 abstract "Obesity and atrial fibrillation have risen to epidemic levels worldwide and may continue to grow over the next decades. Emerging evidence suggests that obesity promotes atrial and ventricular arrhythmias. This has led to trials employing various strategies with the ultimate goal of decreasing the atrial arrhythmic burden in obese patients. The effectiveness of these interventions remains to be determined. Obesity is defined by the expansion of adipose mass, making adipocytes a prime candidate to mediate the pro-arrhythmogenic effects of obesity. The molecular mechanisms linking obesity and adipocytes to increased arrhythmogenicity in both the atria and ventricles remain poorly understood. In this focused review, we highlight areas of potential molecular interplay between adipocytes and cardiomyocytes. The effects of adipocytes may be direct, local or remote. Direct effect refers to adipocyte or fatty infiltration of the atrial and ventricular myocardium itself, possibly causing increased dispersion of normal myocardial electrical signals and fibrotic substrate of adipocytes that promote reentry or adipocytes serving as a direct source of aberrant signals. Local effects may originate from nearby adipose depots, specifically epicardial adipose tissue (EAT) and pericardial adipose tissue, which may play a role in the secretion of adipokines and chemokines that can incite inflammation given the direct contact and disrupt the conduction system. Adipocytes can also have a remote effect on the myocardium arising from their systemic secretion of adipokines, cytokines and metabolites. These factors may lead to mitochondrial dysfunction, oxidative stress, autophagy, mitophagy, autonomic dysfunction, and cardiomyocyte death to ultimately produce a pro-arrhythmogenic state. By better understanding the molecular mechanisms connecting dysfunctional adipocytes and arrhythmias, novel therapies may be developed to sever the link between obesity and arrhythmias." @default.
- W2903513170 created "2018-12-11" @default.
- W2903513170 creator A5011588619 @default.
- W2903513170 creator A5034330473 @default.
- W2903513170 creator A5037928999 @default.
- W2903513170 creator A5046740115 @default.
- W2903513170 date "2018-12-05" @default.
- W2903513170 modified "2023-10-16" @default.
- W2903513170 title "Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions" @default.
- W2903513170 cites W1122828333 @default.
- W2903513170 cites W122674692 @default.
- W2903513170 cites W140098974 @default.
- W2903513170 cites W1492107490 @default.
- W2903513170 cites W1523693806 @default.
- W2903513170 cites W1694069654 @default.
- W2903513170 cites W1735188324 @default.
- W2903513170 cites W1771411253 @default.
- W2903513170 cites W1965569235 @default.
- W2903513170 cites W1966140207 @default.
- W2903513170 cites W1967898940 @default.
- W2903513170 cites W1967964480 @default.
- W2903513170 cites W1971404519 @default.
- W2903513170 cites W1975203323 @default.
- W2903513170 cites W1976967218 @default.
- W2903513170 cites W1979225600 @default.
- W2903513170 cites W1981747612 @default.
- W2903513170 cites W1984456316 @default.
- W2903513170 cites W1986511194 @default.
- W2903513170 cites W1987240861 @default.
- W2903513170 cites W1988123856 @default.
- W2903513170 cites W1990417844 @default.
- W2903513170 cites W1994823455 @default.
- W2903513170 cites W1998855918 @default.
- W2903513170 cites W2001197934 @default.
- W2903513170 cites W2008150005 @default.
- W2903513170 cites W2018825408 @default.
- W2903513170 cites W2019002843 @default.
- W2903513170 cites W2019870695 @default.
- W2903513170 cites W2023263797 @default.
- W2903513170 cites W2025444835 @default.
- W2903513170 cites W2026310866 @default.
- W2903513170 cites W2029827227 @default.
- W2903513170 cites W2032520632 @default.
- W2903513170 cites W2039577288 @default.
- W2903513170 cites W2041448329 @default.
- W2903513170 cites W2042091812 @default.
- W2903513170 cites W2042447698 @default.
- W2903513170 cites W2044779639 @default.
- W2903513170 cites W2049514014 @default.
- W2903513170 cites W2053382717 @default.
- W2903513170 cites W2069650182 @default.
- W2903513170 cites W2081166327 @default.
- W2903513170 cites W2081602781 @default.
- W2903513170 cites W2082652795 @default.
- W2903513170 cites W2087513437 @default.
- W2903513170 cites W2088120774 @default.
- W2903513170 cites W2091997631 @default.
- W2903513170 cites W2095471709 @default.
- W2903513170 cites W2098267336 @default.
- W2903513170 cites W2099831545 @default.
- W2903513170 cites W2103613140 @default.
- W2903513170 cites W2104380511 @default.
- W2903513170 cites W2106201098 @default.
- W2903513170 cites W2106774419 @default.
- W2903513170 cites W2109396853 @default.
- W2903513170 cites W2109815357 @default.
- W2903513170 cites W2119174768 @default.
- W2903513170 cites W2124692765 @default.
- W2903513170 cites W2124821727 @default.
- W2903513170 cites W2127777817 @default.
- W2903513170 cites W2128206941 @default.
- W2903513170 cites W2130306265 @default.
- W2903513170 cites W2130734884 @default.
- W2903513170 cites W2134803072 @default.
- W2903513170 cites W2136746143 @default.
- W2903513170 cites W2137603919 @default.
- W2903513170 cites W2139959600 @default.
- W2903513170 cites W2142480862 @default.
- W2903513170 cites W2150232019 @default.
- W2903513170 cites W2151265492 @default.
- W2903513170 cites W2160477565 @default.
- W2903513170 cites W2164671913 @default.
- W2903513170 cites W2165334726 @default.
- W2903513170 cites W2167117819 @default.
- W2903513170 cites W2169030657 @default.
- W2903513170 cites W2169507034 @default.
- W2903513170 cites W2170399575 @default.
- W2903513170 cites W2174206013 @default.
- W2903513170 cites W2192055987 @default.
- W2903513170 cites W2199961666 @default.
- W2903513170 cites W2204493932 @default.
- W2903513170 cites W2206025985 @default.
- W2903513170 cites W2219311098 @default.
- W2903513170 cites W2247891525 @default.
- W2903513170 cites W2254631758 @default.
- W2903513170 cites W2261565943 @default.
- W2903513170 cites W2269684859 @default.
- W2903513170 cites W2277256895 @default.
- W2903513170 cites W2291100365 @default.
- W2903513170 cites W2332777704 @default.