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• W2903532022 abstract "MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129 Kai Liu, Yingang Zhang, Liang Liu, Qiling Yuan Department of Orthopedics, The First Affliated Hospital of Xi’an Jiaotong University, Xi’an, China Purpose: This article aimed to investigate the mechanism by which MALAT1 and miR-129 affected the development of osteosarcoma.Methods: Tumor tissues and adjacent tissues of 23 osteosarcoma patients were collected. Normal osteoblasts hFOB1.19 and osteosarcoma cells MG63 were cultured. MG63 cells were transfected and grouped: si-negative control (NC) group, si-MALAT1 group, miR-129 NC group, miR-129 mimics group, p-Empty vector group, p-MALAT1 group, p-MALAT1+ miR-129 mimics group, and p-MALAT1+ si-TGIF2 group. Luciferase reporter assay, Cell Counting Kit-8 assay, Transwell assay, quantitative reverse transcription PCR, Western blot, and Pearson correlation analysis were performed.Results: MALAT1 expression in tumor tissues and MG63 cells was increased (P" @default.
• W2903532022 created "2018-12-11" @default.
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• W2903532022 date "2018-12-01" @default.
• W2903532022 modified "2023-10-04" @default.
• W2903532022 title "<em>MALAT1 </em>promotes proliferation, migration, and invasion of MG63 cells by upregulation of <em>TGIF2 </em>via negatively regulating <em>miR-129</em>" @default.
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• W2903532022 doi "https://doi.org/10.2147/ott.s182993" @default.
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