Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903535534> ?p ?o ?g. }
- W2903535534 abstract "Vascular endothelial growth factor receptor-3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic vascular overgrowth and ensure proper lymph vessel development. Here, we show that endothelial cell-specific depletion of integrin-linked kinase (ILK) in mouse embryos hyper-activates VEGFR3 signalling and leads to overgrowth of the jugular lymph sacs/primordial thoracic ducts, oedema and embryonic lethality. Lymphatic endothelial cell (LEC)-specific deletion of Ilk in adult mice initiates lymphatic vascular expansion in different organs, including cornea, skin and myocardium. Knockdown of ILK in human LECs triggers VEGFR3 tyrosine phosphorylation and proliferation. ILK is further found to impede interactions between VEGFR3 and β1 integrin in vitro and in vivo, and endothelial cell-specific deletion of an Itgb1 allele rescues the excessive lymphatic vascular growth observed upon ILK depletion. Finally, mechanical stimulation disrupts the assembly of ILK and β1 integrin, releasing the integrin to enable its interaction with VEGFR3. Our data suggest that ILK facilitates mechanically regulated VEGFR3 signalling via controlling its interaction with β1 integrin and thus ensures proper development of lymphatic vessels." @default.
- W2903535534 created "2018-12-11" @default.
- W2903535534 creator A5006690579 @default.
- W2903535534 creator A5017480661 @default.
- W2903535534 creator A5019382849 @default.
- W2903535534 creator A5029195429 @default.
- W2903535534 creator A5043334371 @default.
- W2903535534 creator A5052695655 @default.
- W2903535534 creator A5052954870 @default.
- W2903535534 creator A5055416673 @default.
- W2903535534 creator A5063288234 @default.
- W2903535534 creator A5068791880 @default.
- W2903535534 creator A5087985214 @default.
- W2903535534 creator A5089273180 @default.
- W2903535534 date "2018-12-05" @default.
- W2903535534 modified "2023-10-14" @default.
- W2903535534 title "Identification of<scp>ILK</scp>as a critical regulator of<scp>VEGFR</scp>3 signalling and lymphatic vascular growth" @default.
- W2903535534 cites W1489873347 @default.
- W2903535534 cites W1568237782 @default.
- W2903535534 cites W1570971207 @default.
- W2903535534 cites W1576773659 @default.
- W2903535534 cites W1600324901 @default.
- W2903535534 cites W1783353478 @default.
- W2903535534 cites W1811064827 @default.
- W2903535534 cites W1819766005 @default.
- W2903535534 cites W1839628238 @default.
- W2903535534 cites W1963494127 @default.
- W2903535534 cites W1964952370 @default.
- W2903535534 cites W1969695473 @default.
- W2903535534 cites W1971643696 @default.
- W2903535534 cites W1973096186 @default.
- W2903535534 cites W1992496728 @default.
- W2903535534 cites W1993913999 @default.
- W2903535534 cites W1994638693 @default.
- W2903535534 cites W1994695426 @default.
- W2903535534 cites W2000653676 @default.
- W2903535534 cites W2000754568 @default.
- W2903535534 cites W2001524010 @default.
- W2903535534 cites W2003450086 @default.
- W2903535534 cites W2013692456 @default.
- W2903535534 cites W2013730676 @default.
- W2903535534 cites W2017390700 @default.
- W2903535534 cites W2023052504 @default.
- W2903535534 cites W2023614421 @default.
- W2903535534 cites W2025173623 @default.
- W2903535534 cites W2025933554 @default.
- W2903535534 cites W2026642794 @default.
- W2903535534 cites W2027306387 @default.
- W2903535534 cites W2029851739 @default.
- W2903535534 cites W2030084515 @default.
- W2903535534 cites W2031050197 @default.
- W2903535534 cites W2043334949 @default.
- W2903535534 cites W2044863867 @default.
- W2903535534 cites W2047232397 @default.
- W2903535534 cites W2052133163 @default.
- W2903535534 cites W2060136332 @default.
- W2903535534 cites W2061708016 @default.
- W2903535534 cites W2062143592 @default.
- W2903535534 cites W2062679525 @default.
- W2903535534 cites W2067150213 @default.
- W2903535534 cites W2067838633 @default.
- W2903535534 cites W2067851515 @default.
- W2903535534 cites W2072889522 @default.
- W2903535534 cites W2075131851 @default.
- W2903535534 cites W2090114064 @default.
- W2903535534 cites W2090890518 @default.
- W2903535534 cites W2094385181 @default.
- W2903535534 cites W2096156778 @default.
- W2903535534 cites W2096608993 @default.
- W2903535534 cites W2097731330 @default.
- W2903535534 cites W2101244168 @default.
- W2903535534 cites W2104633662 @default.
- W2903535534 cites W2107537216 @default.
- W2903535534 cites W2108574077 @default.
- W2903535534 cites W2114712140 @default.
- W2903535534 cites W2122127644 @default.
- W2903535534 cites W2122694926 @default.
- W2903535534 cites W2123055975 @default.
- W2903535534 cites W2125156464 @default.
- W2903535534 cites W2125861553 @default.
- W2903535534 cites W2131398028 @default.
- W2903535534 cites W2134812217 @default.
- W2903535534 cites W2138019675 @default.
- W2903535534 cites W2142676428 @default.
- W2903535534 cites W2142893093 @default.
- W2903535534 cites W2146021659 @default.
- W2903535534 cites W2146500145 @default.
- W2903535534 cites W2147153812 @default.
- W2903535534 cites W2147343237 @default.
- W2903535534 cites W2148062709 @default.
- W2903535534 cites W2154410414 @default.
- W2903535534 cites W2155591311 @default.
- W2903535534 cites W2158183156 @default.
- W2903535534 cites W2160167323 @default.
- W2903535534 cites W2161020445 @default.
- W2903535534 cites W2162826750 @default.
- W2903535534 cites W2164078851 @default.
- W2903535534 cites W2167033631 @default.
- W2903535534 cites W2168616374 @default.
- W2903535534 cites W2258622567 @default.