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- W2903545930 abstract "Cefuroxime, a second-generation cephalosporin antibiotic, was synthesized from 7-amino cephalosporinic acid (7-ACA) and ( Z )-2-methoxyimino-2-(furyl-2-yl) acetic acid ammonium salt (SMIA) as starting materials. The total yield of cefuroxime synthesized via the 4-step scheme was 42%. The novel feature of this study was the use of oxalyl chloride activating reagent which replaced phosphoryl chloride in the activation of SMIA. The result showed that the yield was 90% in the reaction time of 1.5 hours. Especially, this synthesis can be considered as a green process because the waste water only contained NH 4 Cl, CO and CO 2 non-toxic compounds." @default.
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- W2903545930 date "2018-09-03" @default.
- W2903545930 modified "2023-09-23" @default.
- W2903545930 title "A Novel Synthesis of Cefuroxime from 7-amino Cephalosporanic Acid (7-ACA)" @default.
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