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- W2903589812 abstract "Summary Background Melasma is an acquired, chronic, recurrent hypermelanosis that occurs exclusively in areas exposed to the sun. Its treatment can be very challenging. Tranexamic acid (TA) is an inhibitor of plasmin, and it is a synthetic derivative of the amino acid lysine that reversibly blocks binding sites on the plasminogen molecule, inhibiting the plasminogen activator from converting plasminogen to plasmin. Aims This study evaluated the efficacy of oral TA in the treatment of melasma in patients from a philanthropic dermatological clinic. Patients/Methods This was a monocentric, randomized, double‐blind, controlled clinical trial. Patients with facial melasma were randomly divided into the following two groups: A (TA 250 mg orally twice daily) or B (oral placebo twice daily). Evaluations were performed before and after 12 weeks of treatment with photographs, colorimetry, MELASQoL, and MASI. All patients were instructed to use tinted sunscreen (SPF 50). Results Of the 47 patients selected, 37 completed the study, with 20 in group A and 17 in group B; the patients consisted of one male and 36 females, and the mean age was 43.97 years old. Based on the four methods of evaluation, the melasma in 50% of patients in group A improved versus only 5.9% of patients in group B ( P < 0.005). There was an improvement according to all evaluation methods in the treatment group. No patient had severe side effects. Conclusions We conclude that tranexamic acid was effective in 50% of patients according to four methods of evaluation when compared to the placebo." @default.
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- W2903589812 date "2018-12-09" @default.
- W2903589812 modified "2023-10-02" @default.
- W2903589812 title "Evaluation of oral tranexamic acid in the treatment of melasma" @default.
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- W2903589812 doi "https://doi.org/10.1111/jocd.12830" @default.
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