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• W2903609539 endingPage "19" @default.
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• W2903609539 abstract "Levetiracetam for epilepsy: an evidence map of efficacy, safety and economic profiles Zhan-Miao Yi,1–3 Cheng Wen,1,2 Ting Cai,4 Lu Xu,4 Xu-Li Zhong,5 Si-Yan Zhan,4,6 Suo-Di Zhai1,3 1Department of Pharmacy, Peking University Third Hospital, Beijing, China; 2Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University Health Science Center, Beijing, China; 3Institute for Drug Evaluation, Peking University Health Science Center, Beijing, China; 4Department of Epidemiology and Bio-statistics, School of Public Health, Peking University Health Science Center, Beijing, China; 5Department of Pharmacy, Children’s Hospital Affiliated to Capital Institute of Pediatrics, Beijing, China; 6Center for Clinical Epidemiology, Peking University Third Hospital, Beijing, China Objective: To evaluate the efficacy, safety and economics of levetiracetam (LEV) for epilepsy. Materials and methods: PubMed, Scopus, the Cochrane Library, OpenGrey.eu and ClinicalTrials.gov were searched for systematic reviews (SRs), meta-analyses, randomized controlled trials (RCTs), observational studies, case reports and economic studies published from January 2007 to April 2018. We used a bubble plot to graphically display information of included studies and conducted meta-analyses to quantitatively synthesize the evidence. Results: A total of 14,803 records were obtained. We included 30 SRs/meta-analyses, 34 RCTs, 18 observational studies, 58 case reports and 2 economic studies after the screening process. The included SRs enrolled patients with pediatric epilepsy, epilepsy in pregnancy, focal epilepsy, generalized epilepsy and refractory focal epilepsy. Meta-analysis of the included RCTs indicated that LEV was as effective as carbamazepine (CBZ; treatment for 6 months: 58.9% vs 64.8%, OR=0.76, 95% CI: 0.50–1.16; 12 months: 54.9% vs 55.5%, OR=1.24, 95% CI: 0.79–1.93), oxcarbazepine (57.7% vs 59.8%, OR=1.34, 95% CI: 0.34–5.23), phenobarbital (50.0% vs 50.9%, OR=1.20, 95% CI: 0.51–2.82) and lamotrigine (LTG; 61.5% vs 57.7%, OR=1.22, 95% CI: 0.90–1.66). SRs and observational studies indicated a low malformation rate and intrauterine death rate for pregnant women, as well as low risk of cognitive side effects. But psychiatric and behavioral side effects could not be ruled out. LEV decreased discontinuation due to adverse events compared with CBZ (OR=0.52, 95% CI: 0.41–0.65), while no difference was found when LEV was compared with placebo and LTG. Two cost-effectiveness evaluations for refractory epilepsy with decision-tree model showed US$ 76.18 per seizure-free day gained in Canada and US$ 44 per seizure-free day gained in Korea. Conclusion: LEV is as effective as CBZ, oxcarbazepine, phenobarbital and LTG and has an advantage for pregnant women and in cognitive functions. Limited evidence supports its cost-effectiveness. Registered number: PROSPERO (No CRD 42017069367). Keywords: seizure freedom, responder rate, quality of life, malformations, neurological development, psychiatric side effects, cost-effectiveness" @default.
• W2903609539 created "2018-12-22" @default.
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• W2903609539 date "2018-12-01" @default.
• W2903609539 modified "2023-10-12" @default.
• W2903609539 title "Levetiracetam for epilepsy: an evidence map of efficacy, safety and economic profiles" @default.
• W2903609539 cites W1125934959 @default.
• W2903609539 cites W1534724830 @default.
• W2903609539 cites W1551261327 @default.
• W2903609539 cites W1571442295 @default.
• W2903609539 cites W1576738253 @default.
• W2903609539 cites W1578004315 @default.
• W2903609539 cites W1651229387 @default.
• W2903609539 cites W1792817040 @default.
• W2903609539 cites W1842398590 @default.
• W2903609539 cites W1845718879 @default.
• W2903609539 cites W1913135426 @default.
• W2903609539 cites W1954945547 @default.
• W2903609539 cites W1964133387 @default.
• W2903609539 cites W1966077613 @default.
• W2903609539 cites W1966327062 @default.
• W2903609539 cites W1969413070 @default.
• W2903609539 cites W1969812621 @default.
• W2903609539 cites W1970167469 @default.
• W2903609539 cites W1970717865 @default.
• W2903609539 cites W1973044275 @default.
• W2903609539 cites W1978928505 @default.
• W2903609539 cites W1979026877 @default.
• W2903609539 cites W1981726207 @default.
• W2903609539 cites W1983105593 @default.
• W2903609539 cites W1984528114 @default.
• W2903609539 cites W1984941261 @default.
• W2903609539 cites W1988893543 @default.
• W2903609539 cites W1989054396 @default.
• W2903609539 cites W1990392556 @default.
• W2903609539 cites W1990977317 @default.
• W2903609539 cites W1993594627 @default.
• W2903609539 cites W1995793067 @default.
• W2903609539 cites W2001310603 @default.
• W2903609539 cites W2003235935 @default.
• W2903609539 cites W2005553101 @default.
• W2903609539 cites W2008864222 @default.
• W2903609539 cites W2009169779 @default.
• W2903609539 cites W2012659256 @default.
• W2903609539 cites W2012779361 @default.
• W2903609539 cites W2016430881 @default.
• W2903609539 cites W2020534571 @default.
• W2903609539 cites W2020538649 @default.
• W2903609539 cites W2021928140 @default.
• W2903609539 cites W2028500192 @default.
• W2903609539 cites W2029348262 @default.
• W2903609539 cites W2037281862 @default.
• W2903609539 cites W2037497822 @default.
• W2903609539 cites W2038172763 @default.
• W2903609539 cites W2040989089 @default.
• W2903609539 cites W2044725131 @default.
• W2903609539 cites W2046070122 @default.
• W2903609539 cites W2048050407 @default.
• W2903609539 cites W2048095005 @default.
• W2903609539 cites W2050673014 @default.
• W2903609539 cites W2052378771 @default.
• W2903609539 cites W2054181432 @default.
• W2903609539 cites W2054260662 @default.
• W2903609539 cites W2055427002 @default.
• W2903609539 cites W2059129785 @default.
• W2903609539 cites W2062160060 @default.
• W2903609539 cites W2063051675 @default.
• W2903609539 cites W2066622149 @default.
• W2903609539 cites W2068954171 @default.
• W2903609539 cites W2069646872 @default.
• W2903609539 cites W2076116463 @default.
• W2903609539 cites W2076516456 @default.
• W2903609539 cites W2079523027 @default.
• W2903609539 cites W2083722381 @default.
• W2903609539 cites W2087243332 @default.
• W2903609539 cites W2089652468 @default.
• W2903609539 cites W2090568688 @default.
• W2903609539 cites W2090583124 @default.
• W2903609539 cites W2091411426 @default.
• W2903609539 cites W2093094710 @default.
• W2903609539 cites W2093099810 @default.
• W2903609539 cites W2094952358 @default.
• W2903609539 cites W2097462102 @default.
• W2903609539 cites W2098923148 @default.
• W2903609539 cites W2098988883 @default.
• W2903609539 cites W2103375566 @default.
• W2903609539 cites W2104308964 @default.
• W2903609539 cites W2113048868 @default.
• W2903609539 cites W2117091900 @default.
• W2903609539 cites W2119790985 @default.
• W2903609539 cites W2120143658 @default.
• W2903609539 cites W2128086159 @default.

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