Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903613388> ?p ?o ?g. }
- W2903613388 endingPage "458" @default.
- W2903613388 startingPage "447" @default.
- W2903613388 abstract "Ulcerative dermatitis (UD) is an idiopathic, spontaneous and progressive disease typically affecting C57BL/6 aged mice with an unknown aetiopathogenesis. For this study, we evaluated 25 cases of UD in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice. Formalin-fixed, paraffin-embedded skin samples were submitted to morphological investigations. Immunohistochemical analysis was performed to characterize and quantify inflammatory cells using CD3, CD45/B220, CD4, CD8 and IL-17 antibodies. Mast cell-bound IgE was investigated by immunofluorescence, whereas serum and cryopreserved skin samples were collected for molecular analysis. Student's t-test (two-tailed) was performed to assess significant differences between the two groups. Affected skin showed extensive areas of ulceration and diffuse, severe and mixed inflammatory infiltrates. No relevant changes were observed in control mice. Immunohistochemical analysis showed a predominant CD3 + CD4 + leukocyte population with fewer CD45/B220 and IL-17 immunolabelled cells and mast cell-bound IgE. Increases in TNFα, IL-1β and Il-6 mRNA expression were observed in the skin of affected animals compared to controls. Serum TNFα and IL-6 did not vary between affected and control mice. Inflammatory infiltrates and cytokine expression were consistent with both Th2/IgE and Th17 differentiation, a typical pattern of a type I hypersensitivity reaction. Overall, our data suggest an allergic-based aetiopathogenesis of UD in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice." @default.
- W2903613388 created "2018-12-22" @default.
- W2903613388 creator A5001650292 @default.
- W2903613388 creator A5006866619 @default.
- W2903613388 creator A5007157411 @default.
- W2903613388 creator A5023165471 @default.
- W2903613388 creator A5023256497 @default.
- W2903613388 creator A5038935870 @default.
- W2903613388 creator A5039222343 @default.
- W2903613388 creator A5044045578 @default.
- W2903613388 creator A5082728314 @default.
- W2903613388 creator A5084789162 @default.
- W2903613388 creator A5086950734 @default.
- W2903613388 date "2018-12-06" @default.
- W2903613388 modified "2023-10-15" @default.
- W2903613388 title "Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice" @default.
- W2903613388 cites W1526931634 @default.
- W2903613388 cites W1591414362 @default.
- W2903613388 cites W1859448372 @default.
- W2903613388 cites W2002765315 @default.
- W2903613388 cites W2002797131 @default.
- W2903613388 cites W2012741656 @default.
- W2903613388 cites W2028770354 @default.
- W2903613388 cites W2034852367 @default.
- W2903613388 cites W2041315822 @default.
- W2903613388 cites W2053058303 @default.
- W2903613388 cites W2065844939 @default.
- W2903613388 cites W2068898313 @default.
- W2903613388 cites W2108615089 @default.
- W2903613388 cites W2115699865 @default.
- W2903613388 cites W2121278044 @default.
- W2903613388 cites W2137520462 @default.
- W2903613388 cites W2141011291 @default.
- W2903613388 cites W2144747469 @default.
- W2903613388 cites W2149615029 @default.
- W2903613388 cites W2165353430 @default.
- W2903613388 cites W2168337532 @default.
- W2903613388 cites W2170752797 @default.
- W2903613388 cites W2230674919 @default.
- W2903613388 cites W2289435573 @default.
- W2903613388 cites W2487896070 @default.
- W2903613388 cites W2541677614 @default.
- W2903613388 cites W2551265329 @default.
- W2903613388 cites W2606676059 @default.
- W2903613388 cites W2622468178 @default.
- W2903613388 cites W2623738179 @default.
- W2903613388 cites W2791144424 @default.
- W2903613388 cites W4253712325 @default.
- W2903613388 doi "https://doi.org/10.1177/0023677218815718" @default.
- W2903613388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30522404" @default.
- W2903613388 hasPublicationYear "2018" @default.
- W2903613388 type Work @default.
- W2903613388 sameAs 2903613388 @default.
- W2903613388 citedByCount "12" @default.
- W2903613388 countsByYear W29036133882020 @default.
- W2903613388 countsByYear W29036133882021 @default.
- W2903613388 countsByYear W29036133882022 @default.
- W2903613388 countsByYear W29036133882023 @default.
- W2903613388 crossrefType "journal-article" @default.
- W2903613388 hasAuthorship W2903613388A5001650292 @default.
- W2903613388 hasAuthorship W2903613388A5006866619 @default.
- W2903613388 hasAuthorship W2903613388A5007157411 @default.
- W2903613388 hasAuthorship W2903613388A5023165471 @default.
- W2903613388 hasAuthorship W2903613388A5023256497 @default.
- W2903613388 hasAuthorship W2903613388A5038935870 @default.
- W2903613388 hasAuthorship W2903613388A5039222343 @default.
- W2903613388 hasAuthorship W2903613388A5044045578 @default.
- W2903613388 hasAuthorship W2903613388A5082728314 @default.
- W2903613388 hasAuthorship W2903613388A5084789162 @default.
- W2903613388 hasAuthorship W2903613388A5086950734 @default.
- W2903613388 hasConcept C114684123 @default.
- W2903613388 hasConcept C141105273 @default.
- W2903613388 hasConcept C142724271 @default.
- W2903613388 hasConcept C159654299 @default.
- W2903613388 hasConcept C167672396 @default.
- W2903613388 hasConcept C203014093 @default.
- W2903613388 hasConcept C204232928 @default.
- W2903613388 hasConcept C2778236600 @default.
- W2903613388 hasConcept C2778690821 @default.
- W2903613388 hasConcept C2779726688 @default.
- W2903613388 hasConcept C2908647359 @default.
- W2903613388 hasConcept C71924100 @default.
- W2903613388 hasConcept C74172505 @default.
- W2903613388 hasConcept C8891405 @default.
- W2903613388 hasConcept C99454951 @default.
- W2903613388 hasConceptScore W2903613388C114684123 @default.
- W2903613388 hasConceptScore W2903613388C141105273 @default.
- W2903613388 hasConceptScore W2903613388C142724271 @default.
- W2903613388 hasConceptScore W2903613388C159654299 @default.
- W2903613388 hasConceptScore W2903613388C167672396 @default.
- W2903613388 hasConceptScore W2903613388C203014093 @default.
- W2903613388 hasConceptScore W2903613388C204232928 @default.
- W2903613388 hasConceptScore W2903613388C2778236600 @default.
- W2903613388 hasConceptScore W2903613388C2778690821 @default.
- W2903613388 hasConceptScore W2903613388C2779726688 @default.
- W2903613388 hasConceptScore W2903613388C2908647359 @default.
- W2903613388 hasConceptScore W2903613388C71924100 @default.
- W2903613388 hasConceptScore W2903613388C74172505 @default.