FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903672987> ?p ?o ?g. }

• W2903672987 endingPage "117" @default.
• W2903672987 startingPage "110" @default.
• W2903672987 abstract "Sustained ventricular arrhythmias (SVAs) lead to sudden cardiac death, for which β- adrenoreceptor blockers are effective. We hypothesized that electrophysiological changes and arrhythmias by β- adrenoreceptor stimulation are crucially related to activation of small-conductance calcium-activated potassium (SK) channels via the increase in Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity. We used normotensive Wistar-Kyoto (WKY) rats and spontaneous hypertensive rats (SHRs). The latter served as a model of left ventricular hypertrophy. We performed dual optical mapping of action potentials and Ca2+ transients, and the effects of isoproterenol and apamin, an SK channel blocker, were evaluated in the Langendorff-perfused hearts. Action potential duration was abbreviated by isoproterenol (100 nM) in both WKY rats and SHRs. In contrast, the CaMKII activity was increased by isoproterenol only in SHRs. In the presence of isoproterenol, apamin prolonged the action potential duration only in SHRs (n = 10, from 116.6 ± 5.05 ms to 125.4 ± 3.80 ms, P = 0.011), which was prevented by KN-93, a CaMKII inhibitor. Increase in Ca2+ transients and shortening of Ca2+ transient duration by isoproterenol were similarly observed in both animals, which was not affected by apamin. Apamin reduced the isoproterenol-induced SVAs and maximal slope of action potential duration restitution curve specifically in SHRs. In conclusion, β- adrenoreceptor stimulation creates arrhythmogenic substrates via the CaMKII-dependent activation of SK channels in cardiac hypertrophy." @default.
• W2903672987 created "2018-12-22" @default.
• W2903672987 creator A5024947625 @default.
• W2903672987 creator A5026350330 @default.
• W2903672987 creator A5028464674 @default.
• W2903672987 creator A5037364638 @default.
• W2903672987 creator A5039655833 @default.
• W2903672987 creator A5044908712 @default.
• W2903672987 creator A5053689089 @default.
• W2903672987 creator A5054208401 @default.
• W2903672987 creator A5057319049 @default.
• W2903672987 date "2019-02-01" @default.
• W2903672987 modified "2023-10-16" @default.
• W2903672987 title "Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII" @default.
• W2903672987 cites W1518075337 @default.
• W2903672987 cites W1838179335 @default.
• W2903672987 cites W1899754108 @default.
• W2903672987 cites W1923716058 @default.
• W2903672987 cites W1967151871 @default.
• W2903672987 cites W1969154199 @default.
• W2903672987 cites W1969618035 @default.
• W2903672987 cites W1971635966 @default.
• W2903672987 cites W1974604615 @default.
• W2903672987 cites W1986061022 @default.
• W2903672987 cites W1991042645 @default.
• W2903672987 cites W1999877293 @default.
• W2903672987 cites W2027472801 @default.
• W2903672987 cites W2041414050 @default.
• W2903672987 cites W2049223044 @default.
• W2903672987 cites W2063000438 @default.
• W2903672987 cites W2064438064 @default.
• W2903672987 cites W2080066663 @default.
• W2903672987 cites W2081936272 @default.
• W2903672987 cites W2094151523 @default.
• W2903672987 cites W2094957401 @default.
• W2903672987 cites W2096477908 @default.
• W2903672987 cites W2100968549 @default.
• W2903672987 cites W2111174244 @default.
• W2903672987 cites W2114130324 @default.
• W2903672987 cites W2115475608 @default.
• W2903672987 cites W2125058889 @default.
• W2903672987 cites W2131340537 @default.
• W2903672987 cites W2152124147 @default.
• W2903672987 cites W2153624323 @default.
• W2903672987 cites W2156681652 @default.
• W2903672987 cites W2171777264 @default.
• W2903672987 cites W2339609839 @default.
• W2903672987 doi "https://doi.org/10.1016/j.ejphar.2018.12.011" @default.
• W2903672987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30529196" @default.
• W2903672987 hasPublicationYear "2019" @default.
• W2903672987 type Work @default.
• W2903672987 sameAs 2903672987 @default.
• W2903672987 citedByCount "15" @default.
• W2903672987 countsByYear W29036729872019 @default.
• W2903672987 countsByYear W29036729872020 @default.
• W2903672987 countsByYear W29036729872021 @default.
• W2903672987 countsByYear W29036729872022 @default.
• W2903672987 countsByYear W29036729872023 @default.
• W2903672987 crossrefType "journal-article" @default.
• W2903672987 hasAuthorship W2903672987A5024947625 @default.
• W2903672987 hasAuthorship W2903672987A5026350330 @default.
• W2903672987 hasAuthorship W2903672987A5028464674 @default.
• W2903672987 hasAuthorship W2903672987A5037364638 @default.
• W2903672987 hasAuthorship W2903672987A5039655833 @default.
• W2903672987 hasAuthorship W2903672987A5044908712 @default.
• W2903672987 hasAuthorship W2903672987A5053689089 @default.
• W2903672987 hasAuthorship W2903672987A5054208401 @default.
• W2903672987 hasAuthorship W2903672987A5057319049 @default.
• W2903672987 hasBestOaLocation W29036729872 @default.
• W2903672987 hasConcept C126322002 @default.
• W2903672987 hasConcept C134018914 @default.
• W2903672987 hasConcept C149786707 @default.
• W2903672987 hasConcept C170493617 @default.
• W2903672987 hasConcept C185592680 @default.
• W2903672987 hasConcept C24998067 @default.
• W2903672987 hasConcept C2776919887 @default.
• W2903672987 hasConcept C2778457506 @default.
• W2903672987 hasConcept C50254741 @default.
• W2903672987 hasConcept C519063684 @default.
• W2903672987 hasConcept C71924100 @default.
• W2903672987 hasConcept C83743174 @default.
• W2903672987 hasConceptScore W2903672987C126322002 @default.
• W2903672987 hasConceptScore W2903672987C134018914 @default.
• W2903672987 hasConceptScore W2903672987C149786707 @default.
• W2903672987 hasConceptScore W2903672987C170493617 @default.
• W2903672987 hasConceptScore W2903672987C185592680 @default.
• W2903672987 hasConceptScore W2903672987C24998067 @default.
• W2903672987 hasConceptScore W2903672987C2776919887 @default.
• W2903672987 hasConceptScore W2903672987C2778457506 @default.
• W2903672987 hasConceptScore W2903672987C50254741 @default.
• W2903672987 hasConceptScore W2903672987C519063684 @default.
• W2903672987 hasConceptScore W2903672987C71924100 @default.
• W2903672987 hasConceptScore W2903672987C83743174 @default.
• W2903672987 hasLocation W29036729871 @default.
• W2903672987 hasLocation W29036729872 @default.
• W2903672987 hasLocation W29036729873 @default.
• W2903672987 hasOpenAccess W2903672987 @default.
• W2903672987 hasPrimaryLocation W29036729871 @default.

• next