Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903710086> ?p ?o ?g. }
- W2903710086 endingPage "1801586" @default.
- W2903710086 startingPage "1801586" @default.
- W2903710086 abstract "Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of the disease progression. Poor clinical outcomes are displayed due to the irreversible damages caused by early microglia abnormality which triggers disease development before identical symptoms emerge. Based on the crosstalk between microglia and brain microenvironment, a reactive oxygen species (ROS)-responsive polymeric micelle system (Ab-PEG-LysB/curcumin (APLB/CUR)) is reported to normalize the oxidative and inflammatory microenvironment and reeducate microglia from an early phase of AD. Through an β-amyloid (Aβ) transportation-mimicked pathway, the micelles can accumulate into the diseased regions and exert synergistic effects of polymer-based ROS scavenging and cargo-based Aβ inhibition upon microenvironment stimuli. This multitarget strategy exhibits gradual correction of the brain microenvironment, efficient neuroprotection, and microglia modulation, leading to decreased Aβ plaque burdens and consequently enhanced cognitive functions in APPswe/PSEN1dE9 model mice. The results indicate that microglia can be exploited as an early target for AD treatment and their states can be controlled via microenvironment modulation." @default.
- W2903710086 created "2018-12-22" @default.
- W2903710086 creator A5003753200 @default.
- W2903710086 creator A5010710133 @default.
- W2903710086 creator A5011051920 @default.
- W2903710086 creator A5011738757 @default.
- W2903710086 creator A5028289642 @default.
- W2903710086 creator A5030370802 @default.
- W2903710086 creator A5035548239 @default.
- W2903710086 creator A5047750943 @default.
- W2903710086 creator A5058555426 @default.
- W2903710086 creator A5063815177 @default.
- W2903710086 creator A5066081927 @default.
- W2903710086 creator A5071773009 @default.
- W2903710086 creator A5076461726 @default.
- W2903710086 creator A5077280689 @default.
- W2903710086 creator A5080456024 @default.
- W2903710086 date "2018-12-12" @default.
- W2903710086 modified "2023-10-16" @default.
- W2903710086 title "Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia" @default.
- W2903710086 cites W1512719559 @default.
- W2903710086 cites W1542215809 @default.
- W2903710086 cites W1581535372 @default.
- W2903710086 cites W1841850981 @default.
- W2903710086 cites W1964117773 @default.
- W2903710086 cites W1968030855 @default.
- W2903710086 cites W1972165428 @default.
- W2903710086 cites W1991457465 @default.
- W2903710086 cites W2002181764 @default.
- W2903710086 cites W2003813921 @default.
- W2903710086 cites W2004349171 @default.
- W2903710086 cites W2015989345 @default.
- W2903710086 cites W2016664803 @default.
- W2903710086 cites W2017615265 @default.
- W2903710086 cites W2041851050 @default.
- W2903710086 cites W2042466570 @default.
- W2903710086 cites W2043183526 @default.
- W2903710086 cites W2044558227 @default.
- W2903710086 cites W2050794707 @default.
- W2903710086 cites W2052340241 @default.
- W2903710086 cites W2053571233 @default.
- W2903710086 cites W2053704338 @default.
- W2903710086 cites W2055219455 @default.
- W2903710086 cites W2056633438 @default.
- W2903710086 cites W2062034516 @default.
- W2903710086 cites W2064874359 @default.
- W2903710086 cites W2066942909 @default.
- W2903710086 cites W2069119383 @default.
- W2903710086 cites W2080225612 @default.
- W2903710086 cites W2086831255 @default.
- W2903710086 cites W2096989330 @default.
- W2903710086 cites W2119324011 @default.
- W2903710086 cites W2129267808 @default.
- W2903710086 cites W2141262291 @default.
- W2903710086 cites W2155068136 @default.
- W2903710086 cites W2186930964 @default.
- W2903710086 cites W2224546733 @default.
- W2903710086 cites W2238023223 @default.
- W2903710086 cites W2260346813 @default.
- W2903710086 cites W2266035838 @default.
- W2903710086 cites W2310415701 @default.
- W2903710086 cites W2314634699 @default.
- W2903710086 cites W2379046857 @default.
- W2903710086 cites W2479991625 @default.
- W2903710086 cites W2516246660 @default.
- W2903710086 cites W2534155637 @default.
- W2903710086 cites W2544301137 @default.
- W2903710086 cites W2598134302 @default.
- W2903710086 cites W2602280786 @default.
- W2903710086 cites W2602597722 @default.
- W2903710086 cites W2619332462 @default.
- W2903710086 cites W2785098723 @default.
- W2903710086 cites W2903710086 @default.
- W2903710086 cites W4241175784 @default.
- W2903710086 cites W4247759744 @default.
- W2903710086 cites W883464414 @default.
- W2903710086 doi "https://doi.org/10.1002/advs.201801586" @default.
- W2903710086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6382295" @default.
- W2903710086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30828531" @default.
- W2903710086 hasPublicationYear "2018" @default.
- W2903710086 type Work @default.
- W2903710086 sameAs 2903710086 @default.
- W2903710086 citedByCount "77" @default.
- W2903710086 countsByYear W29037100862019 @default.
- W2903710086 countsByYear W29037100862020 @default.
- W2903710086 countsByYear W29037100862021 @default.
- W2903710086 countsByYear W29037100862022 @default.
- W2903710086 countsByYear W29037100862023 @default.
- W2903710086 crossrefType "journal-article" @default.
- W2903710086 hasAuthorship W2903710086A5003753200 @default.
- W2903710086 hasAuthorship W2903710086A5010710133 @default.
- W2903710086 hasAuthorship W2903710086A5011051920 @default.
- W2903710086 hasAuthorship W2903710086A5011738757 @default.
- W2903710086 hasAuthorship W2903710086A5028289642 @default.
- W2903710086 hasAuthorship W2903710086A5030370802 @default.
- W2903710086 hasAuthorship W2903710086A5035548239 @default.
- W2903710086 hasAuthorship W2903710086A5047750943 @default.
- W2903710086 hasAuthorship W2903710086A5058555426 @default.