Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903729963> ?p ?o ?g. }
- W2903729963 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There is thus an urgent unmet clinical need to develop effective anticancer drugs to treat pancreatic cancer. Here, we study the potential of repurposing monensin as an anticancer drug for chemo-resistant pancreatic cancer. Using the two commonly-used chemo-resistant pancreatic cancer cell lines PANC-1 and MiaPaCa-2, we show that monensin suppresses cell proliferation and migration, and cell cycle progression, while solicits apoptosis in pancreatic cancer lines at a low micromole range. Moreover, monensin functions synergistically with gemcitabine or EGFR inhibitor erlotinib in suppressing cell growth and inducing cell death of pancreatic cancer cells. Mechanistically, monensin suppresses numerous cancer-associated pathways, such as E2F/DP1, STAT1/2, NFkB, AP-1, Elk-1/SRF, and represses EGFR expression in pancreatic cancer lines. Furthermore, the in vivo study shows that monensin blunts PDAC xenograft tumor growth by suppressing cell proliferation via targeting EGFR pathway. Therefore, our findings demonstrate that monensin can be repurposed as an effective anti-pancreatic cancer drug even though more investigations are needed to validate its safety and anticancer efficacy in pre-clinical and clinical models." @default.
- W2903729963 created "2018-12-22" @default.
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- W2903729963 date "2018-12-01" @default.
- W2903729963 modified "2023-10-17" @default.
- W2903729963 title "Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway" @default.
- W2903729963 cites W1931508686 @default.
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- W2903729963 cites W1971475600 @default.
- W2903729963 cites W1976284083 @default.
- W2903729963 cites W2006452977 @default.
- W2903729963 cites W2006622612 @default.
- W2903729963 cites W2009946602 @default.
- W2903729963 cites W2011376064 @default.
- W2903729963 cites W2013668655 @default.
- W2903729963 cites W2013687141 @default.
- W2903729963 cites W2022936070 @default.
- W2903729963 cites W2023292535 @default.
- W2903729963 cites W2033707323 @default.
- W2903729963 cites W2041933568 @default.
- W2903729963 cites W2045233171 @default.
- W2903729963 cites W2045778161 @default.
- W2903729963 cites W2063475555 @default.
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- W2903729963 cites W2066737158 @default.
- W2903729963 cites W2067713829 @default.
- W2903729963 cites W2072194939 @default.
- W2903729963 cites W2075642848 @default.
- W2903729963 cites W2087466845 @default.
- W2903729963 cites W2089378397 @default.
- W2903729963 cites W2090641109 @default.
- W2903729963 cites W2091728033 @default.
- W2903729963 cites W2091920265 @default.
- W2903729963 cites W2094134393 @default.
- W2903729963 cites W2096439168 @default.
- W2903729963 cites W2103562758 @default.
- W2903729963 cites W2109858025 @default.
- W2903729963 cites W2112278084 @default.
- W2903729963 cites W2116144169 @default.
- W2903729963 cites W2120166815 @default.
- W2903729963 cites W2120927552 @default.
- W2903729963 cites W2122321442 @default.
- W2903729963 cites W2122364340 @default.
- W2903729963 cites W2123187034 @default.
- W2903729963 cites W2123845167 @default.
- W2903729963 cites W2128246136 @default.
- W2903729963 cites W2128542677 @default.
- W2903729963 cites W2132051926 @default.
- W2903729963 cites W2147188402 @default.
- W2903729963 cites W2148311963 @default.
- W2903729963 cites W2151285027 @default.
- W2903729963 cites W2155466257 @default.
- W2903729963 cites W2155571407 @default.
- W2903729963 cites W2158134441 @default.
- W2903729963 cites W2160391606 @default.
- W2903729963 cites W2162098634 @default.
- W2903729963 cites W2162579298 @default.
- W2903729963 cites W2192943385 @default.
- W2903729963 cites W2195407532 @default.
- W2903729963 cites W2255582474 @default.
- W2903729963 cites W2272984102 @default.
- W2903729963 cites W2285093314 @default.
- W2903729963 cites W2338107694 @default.
- W2903729963 cites W2341554061 @default.
- W2903729963 cites W2396850828 @default.
- W2903729963 cites W2402288690 @default.
- W2903729963 cites W2411216265 @default.
- W2903729963 cites W2475666993 @default.
- W2903729963 cites W2539142011 @default.