Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903780065> ?p ?o ?g. }
- W2903780065 endingPage "2339" @default.
- W2903780065 startingPage "2332" @default.
- W2903780065 abstract "Herpes simplex virus (HSV) infection has been recognized as the most common mucosal disease in humans, manifesting as a life-threatening infection especially for patients with compromised immunity. When combined with the emergence of resistance due to the long-term use of classical antiviral agents, these threats make novel therapeutics for HSV a clinically necessity. We therefore designed and synthesized a series of Janus-type nucleosides by combining the natural genetic alphabets into a singular nucleoside structural unit. We also synthesized a series of new compounds and systematically evaluated their antiviral activity and structure-antiviral activity relationship. The results indicated that both nucleosides and their related intermediates exhibited high anti-HSV-1 activity. Compounds HY17 and HY19, in particular, possessed excellent anti-HSV-1 activity with IC50 values of 0.05 and 0.04 µg/mL, respectively. They also showed broad-spectrum antiviral activity against a multitude of diverse viruses, such as HSV-2, influenza virus A (H3N2), CVB3, HBV, HCV, and HPV. These results suggest that once their mechanisms are fully elucidated, these compounds will prove to be promising candidates as antiviral agents." @default.
- W2903780065 created "2018-12-22" @default.
- W2903780065 creator A5023319759 @default.
- W2903780065 creator A5024124001 @default.
- W2903780065 creator A5056257750 @default.
- W2903780065 creator A5061363517 @default.
- W2903780065 creator A5072053252 @default.
- W2903780065 date "2019-06-01" @default.
- W2903780065 modified "2023-10-18" @default.
- W2903780065 title "Antiviral activities of Janus-type nucleosides and their related oxime-intermediates" @default.
- W2903780065 cites W1156271275 @default.
- W2903780065 cites W1651633793 @default.
- W2903780065 cites W1966198935 @default.
- W2903780065 cites W1973635345 @default.
- W2903780065 cites W1984390216 @default.
- W2903780065 cites W1984755034 @default.
- W2903780065 cites W1992119953 @default.
- W2903780065 cites W1999489724 @default.
- W2903780065 cites W2002161745 @default.
- W2903780065 cites W2004154524 @default.
- W2903780065 cites W2013444064 @default.
- W2903780065 cites W2042507293 @default.
- W2903780065 cites W2045624262 @default.
- W2903780065 cites W2047983769 @default.
- W2903780065 cites W2053948008 @default.
- W2903780065 cites W2065308091 @default.
- W2903780065 cites W2066350610 @default.
- W2903780065 cites W2077661958 @default.
- W2903780065 cites W2083725908 @default.
- W2903780065 cites W2090634114 @default.
- W2903780065 cites W2098751609 @default.
- W2903780065 cites W2115761229 @default.
- W2903780065 cites W2127714783 @default.
- W2903780065 cites W2141574711 @default.
- W2903780065 cites W2151273227 @default.
- W2903780065 cites W2151670363 @default.
- W2903780065 cites W2156244991 @default.
- W2903780065 cites W2156699301 @default.
- W2903780065 cites W2198528112 @default.
- W2903780065 cites W2263859901 @default.
- W2903780065 cites W2280297988 @default.
- W2903780065 cites W2400227769 @default.
- W2903780065 cites W2481374159 @default.
- W2903780065 cites W2504945102 @default.
- W2903780065 cites W2549858084 @default.
- W2903780065 cites W2625206471 @default.
- W2903780065 cites W2735607153 @default.
- W2903780065 cites W2792074753 @default.
- W2903780065 cites W2792464589 @default.
- W2903780065 cites W2875816355 @default.
- W2903780065 cites W4251762852 @default.
- W2903780065 doi "https://doi.org/10.1016/j.bmc.2018.12.014" @default.
- W2903780065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30578076" @default.
- W2903780065 hasPublicationYear "2019" @default.
- W2903780065 type Work @default.
- W2903780065 sameAs 2903780065 @default.
- W2903780065 citedByCount "6" @default.
- W2903780065 countsByYear W29037800652020 @default.
- W2903780065 countsByYear W29037800652021 @default.
- W2903780065 countsByYear W29037800652022 @default.
- W2903780065 countsByYear W29037800652023 @default.
- W2903780065 crossrefType "journal-article" @default.
- W2903780065 hasAuthorship W2903780065A5023319759 @default.
- W2903780065 hasAuthorship W2903780065A5024124001 @default.
- W2903780065 hasAuthorship W2903780065A5056257750 @default.
- W2903780065 hasAuthorship W2903780065A5061363517 @default.
- W2903780065 hasAuthorship W2903780065A5072053252 @default.
- W2903780065 hasConcept C159047783 @default.
- W2903780065 hasConcept C185592680 @default.
- W2903780065 hasConcept C193042331 @default.
- W2903780065 hasConcept C202751555 @default.
- W2903780065 hasConcept C21951064 @default.
- W2903780065 hasConcept C2522874641 @default.
- W2903780065 hasConcept C2776543447 @default.
- W2903780065 hasConcept C2781196997 @default.
- W2903780065 hasConcept C3020442560 @default.
- W2903780065 hasConcept C55493867 @default.
- W2903780065 hasConcept C71240020 @default.
- W2903780065 hasConcept C86803240 @default.
- W2903780065 hasConceptScore W2903780065C159047783 @default.
- W2903780065 hasConceptScore W2903780065C185592680 @default.
- W2903780065 hasConceptScore W2903780065C193042331 @default.
- W2903780065 hasConceptScore W2903780065C202751555 @default.
- W2903780065 hasConceptScore W2903780065C21951064 @default.
- W2903780065 hasConceptScore W2903780065C2522874641 @default.
- W2903780065 hasConceptScore W2903780065C2776543447 @default.
- W2903780065 hasConceptScore W2903780065C2781196997 @default.
- W2903780065 hasConceptScore W2903780065C3020442560 @default.
- W2903780065 hasConceptScore W2903780065C55493867 @default.
- W2903780065 hasConceptScore W2903780065C71240020 @default.
- W2903780065 hasConceptScore W2903780065C86803240 @default.
- W2903780065 hasFunder F4320321001 @default.
- W2903780065 hasIssue "12" @default.
- W2903780065 hasLocation W29037800651 @default.
- W2903780065 hasLocation W29037800652 @default.
- W2903780065 hasOpenAccess W2903780065 @default.
- W2903780065 hasPrimaryLocation W29037800651 @default.
- W2903780065 hasRelatedWork W1972241043 @default.