Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903800992> ?p ?o ?g. }
- W2903800992 abstract "Rheumatic fever (RF) and its subsequent progression to rheumatic heart disease (RHD) are chronic inflammatory disorders prevalent in children and adolescents in underdeveloped countries, and a contributing factor for high morbidity and mortality rates worldwide. Their primary cause is oropharynx infection by Streptococcus pyogenes, whose acetylated residues are recognized by ficolin-1. This is the only membrane-bound, as well as soluble activator molecule of the complement lectin pathway (LP). Although LP genetic polymorphisms are associated with RF, FCN1 gene’s role remains unknown. To understand this role, we haplotyped five FCN1 promoter polymorphisms by sequence-specific amplification in 193 patients (138 with RHD and 55, RF only) and 193 controls, measuring ficolin-1 serum concentrations in 78 patients and 86 controls, using ELISA. Patients presented lower ficolin-1 serum levels (p<0.0001) but did not differ according to cardiac commitment. Control’s genotype distribution was in the Hardy-Weinberg equilibrium. Four alleles (rs2989727: c.-1981A, rs10120023: c.-542A, rs10117466: c.-144A, rs10858293: c.33T), all associated with increased FCN1 gene expression in whole blood or adipose subcutaneous tissue (p=0.000001), were also associated with increased protection against the disease. They occur within the *3C2 haplotype, associated with an increased protection against RF (OR=0.41, p<0.0001) and with higher ficolin-1 levels in patient serum (p=0.03). In addition, major alleles of these same polymorphisms comprehend the most primitive *1 haplotype, associated with increased susceptibility to RF (OR=1.76, p<0.0001). Nevertheless, instead of having a clear-cut protective role, the minor c.-1981A and c.-144A alleles were also associated with additive susceptibility to valvar stenosis and mitral insufficiency (OR=3.75, p=0.009 and OR=3.37, p=0.027, respectively). All associations were independent of age, sex or ethnicity. Thus, minor FCN1 promoter variants may play a protective role against RF, by encouraging bacteria elimination as well as increasing gene expression and protein levels. On the other hand, they may also predispose the patients to RHD symptoms, by probably contributing to chronic inflammation and tissue injury, thus emphasizing the dual importance of ficolin-1 in both conditions." @default.
- W2903800992 created "2018-12-22" @default.
- W2903800992 creator A5038430349 @default.
- W2903800992 creator A5040967172 @default.
- W2903800992 creator A5052043820 @default.
- W2903800992 creator A5073119907 @default.
- W2903800992 creator A5074761424 @default.
- W2903800992 date "2018-12-18" @default.
- W2903800992 modified "2023-09-27" @default.
- W2903800992 title "Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever" @default.
- W2903800992 cites W1487987052 @default.
- W2903800992 cites W1495490827 @default.
- W2903800992 cites W1917127040 @default.
- W2903800992 cites W1940003109 @default.
- W2903800992 cites W1970365484 @default.
- W2903800992 cites W1972951497 @default.
- W2903800992 cites W1976674928 @default.
- W2903800992 cites W1985114541 @default.
- W2903800992 cites W1994282399 @default.
- W2903800992 cites W1997754935 @default.
- W2903800992 cites W2006581388 @default.
- W2903800992 cites W2010304902 @default.
- W2903800992 cites W2015371417 @default.
- W2903800992 cites W2015690645 @default.
- W2903800992 cites W2040533157 @default.
- W2903800992 cites W2046274081 @default.
- W2903800992 cites W2062445513 @default.
- W2903800992 cites W2070589969 @default.
- W2903800992 cites W2075936958 @default.
- W2903800992 cites W2078020746 @default.
- W2903800992 cites W2080422933 @default.
- W2903800992 cites W2088925417 @default.
- W2903800992 cites W2097408755 @default.
- W2903800992 cites W2103451595 @default.
- W2903800992 cites W2117417466 @default.
- W2903800992 cites W2123797660 @default.
- W2903800992 cites W2137622855 @default.
- W2903800992 cites W2144590292 @default.
- W2903800992 cites W2148156541 @default.
- W2903800992 cites W2170805498 @default.
- W2903800992 cites W2220620362 @default.
- W2903800992 cites W2248907500 @default.
- W2903800992 cites W2343577832 @default.
- W2903800992 cites W2537987981 @default.
- W2903800992 cites W2565518336 @default.
- W2903800992 cites W2592802570 @default.
- W2903800992 cites W2607306198 @default.
- W2903800992 cites W2620424880 @default.
- W2903800992 cites W2620904777 @default.
- W2903800992 cites W2739091448 @default.
- W2903800992 cites W2751050179 @default.
- W2903800992 cites W2794605374 @default.
- W2903800992 cites W2889397971 @default.
- W2903800992 cites W2952977999 @default.
- W2903800992 cites W4211073338 @default.
- W2903800992 cites W4246616357 @default.
- W2903800992 doi "https://doi.org/10.3389/fimmu.2018.03009" @default.
- W2903800992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6305461" @default.
- W2903800992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30619357" @default.
- W2903800992 hasPublicationYear "2018" @default.
- W2903800992 type Work @default.
- W2903800992 sameAs 2903800992 @default.
- W2903800992 citedByCount "10" @default.
- W2903800992 countsByYear W29038009922019 @default.
- W2903800992 countsByYear W29038009922020 @default.
- W2903800992 countsByYear W29038009922021 @default.
- W2903800992 countsByYear W29038009922022 @default.
- W2903800992 crossrefType "journal-article" @default.
- W2903800992 hasAuthorship W2903800992A5038430349 @default.
- W2903800992 hasAuthorship W2903800992A5040967172 @default.
- W2903800992 hasAuthorship W2903800992A5052043820 @default.
- W2903800992 hasAuthorship W2903800992A5073119907 @default.
- W2903800992 hasAuthorship W2903800992A5074761424 @default.
- W2903800992 hasBestOaLocation W29038009921 @default.
- W2903800992 hasConcept C104317684 @default.
- W2903800992 hasConcept C111684460 @default.
- W2903800992 hasConcept C124594742 @default.
- W2903800992 hasConcept C126322002 @default.
- W2903800992 hasConcept C135763542 @default.
- W2903800992 hasConcept C159654299 @default.
- W2903800992 hasConcept C171279029 @default.
- W2903800992 hasConcept C180754005 @default.
- W2903800992 hasConcept C197754878 @default.
- W2903800992 hasConcept C203014093 @default.
- W2903800992 hasConcept C203880312 @default.
- W2903800992 hasConcept C2781236483 @default.
- W2903800992 hasConcept C54355233 @default.
- W2903800992 hasConcept C71924100 @default.
- W2903800992 hasConcept C86803240 @default.
- W2903800992 hasConceptScore W2903800992C104317684 @default.
- W2903800992 hasConceptScore W2903800992C111684460 @default.
- W2903800992 hasConceptScore W2903800992C124594742 @default.
- W2903800992 hasConceptScore W2903800992C126322002 @default.
- W2903800992 hasConceptScore W2903800992C135763542 @default.
- W2903800992 hasConceptScore W2903800992C159654299 @default.
- W2903800992 hasConceptScore W2903800992C171279029 @default.
- W2903800992 hasConceptScore W2903800992C180754005 @default.
- W2903800992 hasConceptScore W2903800992C197754878 @default.
- W2903800992 hasConceptScore W2903800992C203014093 @default.
- W2903800992 hasConceptScore W2903800992C203880312 @default.