Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903801932> ?p ?o ?g. }
- W2903801932 abstract "Abstract In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this predictor by increasing its biological plausibility and replication. We re-sequence the four genes using next-generation sequencing. We predict functionality “in silico” of all identified SNPs and test it using gene reporter assays. Using functional SNPs, we develop a new predictor utilizing machine learning algorithms (Discovery Cohort, N = 131) and replicate it in two independent cohorts (Replication Cohort 1, N = 113; Replication Cohort 2, N = 113). After prioritization, four SNPs were used to develop the pharmacogenetic predictor of AP-induced EPS. The model constructed using the Naive Bayes algorithm achieved a 66% of accuracy in the Discovery Cohort, and similar performances in the replication cohorts. The result is an improved pharmacogenetic predictor of AP-induced EPS, which is more robust and generalizable than the original." @default.
- W2903801932 created "2018-12-22" @default.
- W2903801932 creator A5000615082 @default.
- W2903801932 creator A5002548433 @default.
- W2903801932 creator A5003730586 @default.
- W2903801932 creator A5005279855 @default.
- W2903801932 creator A5014661303 @default.
- W2903801932 creator A5025453526 @default.
- W2903801932 creator A5027816426 @default.
- W2903801932 creator A5029677120 @default.
- W2903801932 creator A5032713316 @default.
- W2903801932 creator A5039196986 @default.
- W2903801932 creator A5059493535 @default.
- W2903801932 creator A5085160573 @default.
- W2903801932 date "2018-12-13" @default.
- W2903801932 modified "2023-10-17" @default.
- W2903801932 title "Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipsychotics" @default.
- W2903801932 cites W1531160357 @default.
- W2903801932 cites W1786514222 @default.
- W2903801932 cites W1964866242 @default.
- W2903801932 cites W1969812568 @default.
- W2903801932 cites W1978722353 @default.
- W2903801932 cites W1979115298 @default.
- W2903801932 cites W1991883964 @default.
- W2903801932 cites W1992176272 @default.
- W2903801932 cites W1996838604 @default.
- W2903801932 cites W2008856264 @default.
- W2903801932 cites W2027382784 @default.
- W2903801932 cites W2047066646 @default.
- W2903801932 cites W2050584393 @default.
- W2903801932 cites W2069024810 @default.
- W2903801932 cites W2069849124 @default.
- W2903801932 cites W2077758934 @default.
- W2903801932 cites W2084341220 @default.
- W2903801932 cites W2085800471 @default.
- W2903801932 cites W2091310201 @default.
- W2903801932 cites W2091709203 @default.
- W2903801932 cites W2109907479 @default.
- W2903801932 cites W2112244240 @default.
- W2903801932 cites W2116594433 @default.
- W2903801932 cites W2121323687 @default.
- W2903801932 cites W2123794412 @default.
- W2903801932 cites W2130856032 @default.
- W2903801932 cites W2137263227 @default.
- W2903801932 cites W2137503082 @default.
- W2903801932 cites W2152290963 @default.
- W2903801932 cites W2154572047 @default.
- W2903801932 cites W2165379748 @default.
- W2903801932 cites W2396344501 @default.
- W2903801932 cites W2415617743 @default.
- W2903801932 cites W2501678642 @default.
- W2903801932 cites W2599420949 @default.
- W2903801932 cites W2756463960 @default.
- W2903801932 cites W2809048977 @default.
- W2903801932 cites W4240172337 @default.
- W2903801932 cites W794635120 @default.
- W2903801932 doi "https://doi.org/10.1038/s41398-018-0330-4" @default.
- W2903801932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6293322" @default.
- W2903801932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30546092" @default.
- W2903801932 hasPublicationYear "2018" @default.
- W2903801932 type Work @default.
- W2903801932 sameAs 2903801932 @default.
- W2903801932 citedByCount "10" @default.
- W2903801932 countsByYear W29038019322020 @default.
- W2903801932 countsByYear W29038019322021 @default.
- W2903801932 countsByYear W29038019322022 @default.
- W2903801932 countsByYear W29038019322023 @default.
- W2903801932 crossrefType "journal-article" @default.
- W2903801932 hasAuthorship W2903801932A5000615082 @default.
- W2903801932 hasAuthorship W2903801932A5002548433 @default.
- W2903801932 hasAuthorship W2903801932A5003730586 @default.
- W2903801932 hasAuthorship W2903801932A5005279855 @default.
- W2903801932 hasAuthorship W2903801932A5014661303 @default.
- W2903801932 hasAuthorship W2903801932A5025453526 @default.
- W2903801932 hasAuthorship W2903801932A5027816426 @default.
- W2903801932 hasAuthorship W2903801932A5029677120 @default.
- W2903801932 hasAuthorship W2903801932A5032713316 @default.
- W2903801932 hasAuthorship W2903801932A5039196986 @default.
- W2903801932 hasAuthorship W2903801932A5059493535 @default.
- W2903801932 hasAuthorship W2903801932A5085160573 @default.
- W2903801932 hasBestOaLocation W29038019321 @default.
- W2903801932 hasConcept C104317684 @default.
- W2903801932 hasConcept C118552586 @default.
- W2903801932 hasConcept C12590798 @default.
- W2903801932 hasConcept C126322002 @default.
- W2903801932 hasConcept C135763542 @default.
- W2903801932 hasConcept C153209595 @default.
- W2903801932 hasConcept C159047783 @default.
- W2903801932 hasConcept C2775905019 @default.
- W2903801932 hasConcept C2776412080 @default.
- W2903801932 hasConcept C2780494398 @default.
- W2903801932 hasConcept C31467283 @default.
- W2903801932 hasConcept C54355233 @default.
- W2903801932 hasConcept C55775858 @default.
- W2903801932 hasConcept C70721500 @default.
- W2903801932 hasConcept C71924100 @default.
- W2903801932 hasConcept C72563966 @default.
- W2903801932 hasConcept C86803240 @default.
- W2903801932 hasConceptScore W2903801932C104317684 @default.
- W2903801932 hasConceptScore W2903801932C118552586 @default.