FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903814629> ?p ?o ?g. }

• W2903814629 endingPage "442" @default.
• W2903814629 startingPage "433" @default.
• W2903814629 abstract "Tumour-infiltrating immune cells are a source of important prognostic information for patients with resectable colon cancer. We developed a novel immune model based on systematic assessments of the immune landscape inferred from bulk tumor transcriptomes of stage I-III colon cancer patients. The Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) algorithm was used to estimate the fraction of 22 immune cell types from six microarray public datasets. The random forest method and least absolute shrinkage and selection operator model were then used to establish immunoscores for diagnosis and prognosis. By comparing immune cell compositions in samples of 870 colon cancer patients and 70 normal controls, we constructed a diagnostic model, designated the diagnostic immune risk score (dIRS), that showed high specificity and sensitivity in both the training [area under the curve (AUC) = 0.98, p < 0.001] and validation (AUC 0.96, p < 0.001) sets. We also established a prognostic immune risk score (pIRS) that was found to be an independent prognostic factor for relapse-free survival in every series (training: HR 2.23; validation: HR 1.65; entire: HR 2.01; p < 0.001 for all), which showed better prognostic value than TNM stage. In addition, integration of the pIRS with clinical characteristics in a composite nomogram showed improved accuracy of relapse risk prediction, providing a higher net benefit than TNM stage, with well-fitted calibration curves. The proposed dIRS and pIRS models represent promising novel signatures for the diagnosis and prognosis prediction of colon cancer." @default.
• W2903814629 created "2018-12-22" @default.
• W2903814629 creator A5006442888 @default.
• W2903814629 creator A5025156575 @default.
• W2903814629 creator A5029741432 @default.
• W2903814629 creator A5032770876 @default.
• W2903814629 creator A5066349538 @default.
• W2903814629 creator A5072732141 @default.
• W2903814629 creator A5072833248 @default.
• W2903814629 creator A5078104866 @default.
• W2903814629 creator A5080964631 @default.
• W2903814629 date "2018-12-19" @default.
• W2903814629 modified "2023-10-10" @default.
• W2903814629 title "Immune cell infiltration as a biomarker for the diagnosis and prognosis of stage I–III colon cancer" @default.
• W2903814629 cites W1859257957 @default.
• W2903814629 cites W1934094702 @default.
• W2903814629 cites W1969096316 @default.
• W2903814629 cites W1985987855 @default.
• W2903814629 cites W2008539574 @default.
• W2903814629 cites W2021733365 @default.
• W2903814629 cites W2031102273 @default.
• W2903814629 cites W2049491375 @default.
• W2903814629 cites W2065974896 @default.
• W2903814629 cites W2073618702 @default.
• W2903814629 cites W2076910098 @default.
• W2903814629 cites W2091415498 @default.
• W2903814629 cites W2098026442 @default.
• W2903814629 cites W2130410032 @default.
• W2903814629 cites W2131072420 @default.
• W2903814629 cites W2142300779 @default.
• W2903814629 cites W2170989872 @default.
• W2903814629 cites W2567668099 @default.
• W2903814629 cites W2591483854 @default.
• W2903814629 cites W2593635330 @default.
• W2903814629 cites W2604847258 @default.
• W2903814629 cites W2622499649 @default.
• W2903814629 cites W2736312236 @default.
• W2903814629 cites W2764195238 @default.
• W2903814629 cites W2773278295 @default.
• W2903814629 cites W2789878273 @default.
• W2903814629 cites W2794165001 @default.
• W2903814629 cites W2802206159 @default.
• W2903814629 cites W2802343656 @default.
• W2903814629 cites W4239180165 @default.
• W2903814629 doi "https://doi.org/10.1007/s00262-018-2289-7" @default.
• W2903814629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6426802" @default.
• W2903814629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30564892" @default.
• W2903814629 hasPublicationYear "2018" @default.
• W2903814629 type Work @default.
• W2903814629 sameAs 2903814629 @default.
• W2903814629 citedByCount "176" @default.
• W2903814629 countsByYear W29038146292019 @default.
• W2903814629 countsByYear W29038146292020 @default.
• W2903814629 countsByYear W29038146292021 @default.
• W2903814629 countsByYear W29038146292022 @default.
• W2903814629 countsByYear W29038146292023 @default.
• W2903814629 crossrefType "journal-article" @default.
• W2903814629 hasAuthorship W2903814629A5006442888 @default.
• W2903814629 hasAuthorship W2903814629A5025156575 @default.
• W2903814629 hasAuthorship W2903814629A5029741432 @default.
• W2903814629 hasAuthorship W2903814629A5032770876 @default.
• W2903814629 hasAuthorship W2903814629A5066349538 @default.
• W2903814629 hasAuthorship W2903814629A5072732141 @default.
• W2903814629 hasAuthorship W2903814629A5072833248 @default.
• W2903814629 hasAuthorship W2903814629A5078104866 @default.
• W2903814629 hasAuthorship W2903814629A5080964631 @default.
• W2903814629 hasBestOaLocation W29038146291 @default.
• W2903814629 hasConcept C10515644 @default.
• W2903814629 hasConcept C121608353 @default.
• W2903814629 hasConcept C126322002 @default.
• W2903814629 hasConcept C143998085 @default.
• W2903814629 hasConcept C146357865 @default.
• W2903814629 hasConcept C151730666 @default.
• W2903814629 hasConcept C203014093 @default.
• W2903814629 hasConcept C2776808855 @default.
• W2903814629 hasConcept C3018130915 @default.
• W2903814629 hasConcept C34626388 @default.
• W2903814629 hasConcept C526805850 @default.
• W2903814629 hasConcept C58471807 @default.
• W2903814629 hasConcept C71924100 @default.
• W2903814629 hasConcept C86803240 @default.
• W2903814629 hasConcept C8891405 @default.
• W2903814629 hasConceptScore W2903814629C10515644 @default.
• W2903814629 hasConceptScore W2903814629C121608353 @default.
• W2903814629 hasConceptScore W2903814629C126322002 @default.
• W2903814629 hasConceptScore W2903814629C143998085 @default.
• W2903814629 hasConceptScore W2903814629C146357865 @default.
• W2903814629 hasConceptScore W2903814629C151730666 @default.
• W2903814629 hasConceptScore W2903814629C203014093 @default.
• W2903814629 hasConceptScore W2903814629C2776808855 @default.
• W2903814629 hasConceptScore W2903814629C3018130915 @default.
• W2903814629 hasConceptScore W2903814629C34626388 @default.
• W2903814629 hasConceptScore W2903814629C526805850 @default.
• W2903814629 hasConceptScore W2903814629C58471807 @default.
• W2903814629 hasConceptScore W2903814629C71924100 @default.
• W2903814629 hasConceptScore W2903814629C86803240 @default.
• W2903814629 hasConceptScore W2903814629C8891405 @default.
• W2903814629 hasFunder F4320321001 @default.

• next