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- W290383716 abstract "Intellectual disability (ID) is a broad disorder characterized by early onset limitations in intellectual functioning and adaptive behavior. Genetic and functional studies have revealed a role for epigenetics in the underlying pathology of ID. ID can result from aberrant epigenetic silencing of important neuronal genes or from mutations in core members of the epigenetic machinery. Aberrant epigenetic silencing occurs in the nucleotide repeat disorder, fragile X syndrome, and in the imprinting disorders Angelman syndrome and Prader–Willi syndrome. Mutations in epigenetic regulators are found in a diverse array of ID disorders, including Rett syndrome, ATR-X syndrome, Rubenstein–Taybi syndrome, and Kleefstra syndrome. There are over 30 ID genes encoding proteins that have a direct role in modification of chromatin structure, and these proteins participate in DNA methylation, ATP-dependent chromatin remodeling, and posttranslational modification of histones. Recent studies are beginning to reveal a complex role for epigenetic regulators in human cognition." @default.
- W290383716 created "2016-06-24" @default.
- W290383716 creator A5014291283 @default.
- W290383716 creator A5047120336 @default.
- W290383716 date "2014-01-01" @default.
- W290383716 modified "2023-10-16" @default.
- W290383716 title "Epigenetics in Intellectual Disability" @default.
- W290383716 cites W1541050437 @default.
- W290383716 cites W1559742681 @default.
- W290383716 cites W1559859249 @default.
- W290383716 cites W1917476040 @default.
- W290383716 cites W1963557285 @default.
- W290383716 cites W1964444099 @default.
- W290383716 cites W1968916422 @default.
- W290383716 cites W1973214775 @default.
- W290383716 cites W1974850149 @default.
- W290383716 cites W1975728749 @default.
- W290383716 cites W1979833232 @default.
- W290383716 cites W1980726773 @default.
- W290383716 cites W1981615602 @default.
- W290383716 cites W1982946759 @default.
- W290383716 cites W1985513877 @default.
- W290383716 cites W1991378696 @default.
- W290383716 cites W1992577657 @default.
- W290383716 cites W1993401016 @default.
- W290383716 cites W1995021156 @default.
- W290383716 cites W1997233598 @default.
- W290383716 cites W1998224364 @default.
- W290383716 cites W2001420461 @default.
- W290383716 cites W2001704867 @default.
- W290383716 cites W2001747783 @default.
- W290383716 cites W2001936578 @default.
- W290383716 cites W2002676132 @default.
- W290383716 cites W2007686616 @default.
- W290383716 cites W2008865929 @default.
- W290383716 cites W2019904951 @default.
- W290383716 cites W2020725656 @default.
- W290383716 cites W2024190224 @default.
- W290383716 cites W2024663595 @default.
- W290383716 cites W2026496218 @default.
- W290383716 cites W2031926951 @default.
- W290383716 cites W2032814455 @default.
- W290383716 cites W2035638429 @default.
- W290383716 cites W2039180361 @default.
- W290383716 cites W2039276157 @default.
- W290383716 cites W2040675004 @default.
- W290383716 cites W2041120010 @default.
- W290383716 cites W2041221704 @default.
- W290383716 cites W2041623568 @default.
- W290383716 cites W2047573503 @default.
- W290383716 cites W2048222359 @default.
- W290383716 cites W2051013729 @default.
- W290383716 cites W2056556069 @default.
- W290383716 cites W2058601962 @default.
- W290383716 cites W2060870400 @default.
- W290383716 cites W2062113306 @default.
- W290383716 cites W2064756496 @default.
- W290383716 cites W2065364505 @default.
- W290383716 cites W2068194528 @default.
- W290383716 cites W2069351794 @default.
- W290383716 cites W2069852012 @default.
- W290383716 cites W2070855223 @default.
- W290383716 cites W2072106835 @default.
- W290383716 cites W2072587374 @default.
- W290383716 cites W2072924157 @default.
- W290383716 cites W2074169344 @default.
- W290383716 cites W2075059777 @default.
- W290383716 cites W2075764106 @default.
- W290383716 cites W2076312647 @default.
- W290383716 cites W2080571195 @default.
- W290383716 cites W2081737839 @default.
- W290383716 cites W2081756408 @default.
- W290383716 cites W2083548220 @default.
- W290383716 cites W2086554513 @default.
- W290383716 cites W2086626128 @default.
- W290383716 cites W2089360863 @default.
- W290383716 cites W2090220750 @default.
- W290383716 cites W2090611194 @default.
- W290383716 cites W2090760765 @default.
- W290383716 cites W2091605994 @default.
- W290383716 cites W2092027270 @default.
- W290383716 cites W2092710299 @default.
- W290383716 cites W2093443640 @default.
- W290383716 cites W2098419288 @default.
- W290383716 cites W2098682209 @default.
- W290383716 cites W2100663971 @default.
- W290383716 cites W2102858085 @default.
- W290383716 cites W2107902316 @default.
- W290383716 cites W2108196925 @default.
- W290383716 cites W2112445327 @default.
- W290383716 cites W2113486281 @default.
- W290383716 cites W2115818350 @default.
- W290383716 cites W2119787118 @default.
- W290383716 cites W2121012521 @default.
- W290383716 cites W2121444603 @default.
- W290383716 cites W2121910267 @default.
- W290383716 cites W2123324115 @default.
- W290383716 cites W2123824748 @default.