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- W2903844399 abstract "The purpose of this study is to use a retrospective cohort of burn patients to evaluate the contribution of oxandrolone on burn care outcomes. Longitudinal clinical data is used to analyze outcomes from a new perspective. Our random-effects longitudinal regression analysis model used temporal clinical data to evaluate oxandrolone’s impact on outcomes (oxandrolone/non-oxandrolone n = 50/11, median length of stay [LOS] = 42.2/39.3, mean weight (kg) = 192.2/207.6, mean initial prealbumin (mg/dL) 10.1/7.5). The resultant predictive models (p < 0.001) described how certain factors influence clinically significant outcomes via a robust data analysis method. LOS was predicted and extended by a greater magnitude of 3rd-degree versus 2nd-degree burns (1.01 versus 0.85 additional days for each %TBSA, p < 0.001). Weight was decreased by LOS (145.2 g lost per day, p < 0.001). Oxandrolone improved prealbumin (3.503 mg/dL increase, p < 0.001) but instead did not influence patient weight (p > 0.05) nor LOS (5.27 days shortening, p = 0.361). Prealbumin over time was also influenced by initial value (0.293 mg/dL, p = 0.003), LOS (0.072 mg/dL increase per additional day, p < 0.001), and the presence of inhalation injury (2.652 mg/dL decrease if present, p = 0.009). Oxandrolone appears to benefit anabolic protein production. It is difficult to isolate the role of oxandrolone on major outcomes due to the concomitant influence of other variables." @default.
- W2903844399 created "2018-12-22" @default.
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- W2903844399 date "2019-06-01" @default.
- W2903844399 modified "2023-10-12" @default.
- W2903844399 title "Assessment of the impact of oxandrolone on outcomes in burn injured patients" @default.
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- W2903844399 doi "https://doi.org/10.1016/j.burns.2018.11.001" @default.
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