Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903865818> ?p ?o ?g. }
- W2903865818 startingPage "493163" @default.
- W2903865818 abstract "ABSTRACT Protecting the nervous system from chronic effects of physical and chemical stress is a pressing clinical challenge, which has sparked intense efforts to identify molecular inhibitors of axon destruction. Yet, one caveat of such strategy is the extent of unintended deleterious effects of blocking axon degeneration systemically. Here we use genetics and pharmacology in zebrafish to show that elimination of the obligate pro-degenerative protein Sarm1 is compatible with neural homeostasis and function, and is glioprotective. Severed axons lacking Sarm1 subsist independently of Schwann-cell support. Regenerating axons in Sarm1 mutants do not reseal with non-degradable axon segments and regain connectivity with peripheral synaptic targets to enable sensorimotor recovery, suggesting that neural-circuit repair is not contingent upon expeditious clearance of damaged axons. Unexpectedly, we found that Sarm1 deficiency increases Schwann-cell resistance to toxicity by diverse chemotherapeutic agents after nerve injury. Our findings anticipate that pharmacological interventions targeting Sarm1 are promising strategies to reduce chronic consequences of neurotrauma." @default.
- W2903865818 created "2018-12-22" @default.
- W2903865818 creator A5002936823 @default.
- W2903865818 creator A5019067997 @default.
- W2903865818 creator A5031219085 @default.
- W2903865818 creator A5040427965 @default.
- W2903865818 creator A5059611385 @default.
- W2903865818 creator A5061123414 @default.
- W2903865818 date "2018-12-11" @default.
- W2903865818 modified "2023-09-23" @default.
- W2903865818 title "Systemic loss of Sarm1 is glioprotective after neurotrauma" @default.
- W2903865818 cites W1235744636 @default.
- W2903865818 cites W1488615278 @default.
- W2903865818 cites W1511198581 @default.
- W2903865818 cites W1538169063 @default.
- W2903865818 cites W1541486590 @default.
- W2903865818 cites W1964863958 @default.
- W2903865818 cites W1969552240 @default.
- W2903865818 cites W1971978102 @default.
- W2903865818 cites W1972814736 @default.
- W2903865818 cites W1973848776 @default.
- W2903865818 cites W1976391205 @default.
- W2903865818 cites W1981239255 @default.
- W2903865818 cites W1983000625 @default.
- W2903865818 cites W1983082992 @default.
- W2903865818 cites W1989239695 @default.
- W2903865818 cites W1993737194 @default.
- W2903865818 cites W1995184879 @default.
- W2903865818 cites W1995860861 @default.
- W2903865818 cites W1997393571 @default.
- W2903865818 cites W1999838520 @default.
- W2903865818 cites W2007531137 @default.
- W2903865818 cites W2009125262 @default.
- W2903865818 cites W2010145940 @default.
- W2903865818 cites W2013093493 @default.
- W2903865818 cites W2014526583 @default.
- W2903865818 cites W2024470896 @default.
- W2903865818 cites W2028787575 @default.
- W2903865818 cites W2030047746 @default.
- W2903865818 cites W2032300647 @default.
- W2903865818 cites W2037829284 @default.
- W2903865818 cites W2038566549 @default.
- W2903865818 cites W2040120130 @default.
- W2903865818 cites W2041355051 @default.
- W2903865818 cites W2042776153 @default.
- W2903865818 cites W2049242177 @default.
- W2903865818 cites W2049646029 @default.
- W2903865818 cites W2050935187 @default.
- W2903865818 cites W2054041060 @default.
- W2903865818 cites W2061107749 @default.
- W2903865818 cites W2062200458 @default.
- W2903865818 cites W2069028571 @default.
- W2903865818 cites W2070381140 @default.
- W2903865818 cites W2070697754 @default.
- W2903865818 cites W2075581714 @default.
- W2903865818 cites W2075925391 @default.
- W2903865818 cites W2090057285 @default.
- W2903865818 cites W2095042810 @default.
- W2903865818 cites W2102232105 @default.
- W2903865818 cites W2110756863 @default.
- W2903865818 cites W2114546997 @default.
- W2903865818 cites W2124774927 @default.
- W2903865818 cites W2126117726 @default.
- W2903865818 cites W2132948621 @default.
- W2903865818 cites W2147490281 @default.
- W2903865818 cites W2150044044 @default.
- W2903865818 cites W2152913938 @default.
- W2903865818 cites W2168486196 @default.
- W2903865818 cites W2176923893 @default.
- W2903865818 cites W2194524172 @default.
- W2903865818 cites W2197934318 @default.
- W2903865818 cites W2256016639 @default.
- W2903865818 cites W2277158176 @default.
- W2903865818 cites W2310994509 @default.
- W2903865818 cites W2319311345 @default.
- W2903865818 cites W2333873972 @default.
- W2903865818 cites W2345128728 @default.
- W2903865818 cites W2381661296 @default.
- W2903865818 cites W2418107006 @default.
- W2903865818 cites W2477716363 @default.
- W2903865818 cites W2483712829 @default.
- W2903865818 cites W2509253943 @default.
- W2903865818 cites W2525723585 @default.
- W2903865818 cites W2526709841 @default.
- W2903865818 cites W2531683815 @default.
- W2903865818 cites W2537687146 @default.
- W2903865818 cites W2545586732 @default.
- W2903865818 cites W2553036254 @default.
- W2903865818 cites W2575965072 @default.
- W2903865818 cites W2578314205 @default.
- W2903865818 cites W2591563223 @default.
- W2903865818 cites W2610196480 @default.
- W2903865818 cites W2613942025 @default.
- W2903865818 cites W2621150072 @default.
- W2903865818 cites W2734623137 @default.
- W2903865818 cites W2734756181 @default.
- W2903865818 cites W2738432120 @default.
- W2903865818 cites W2750650202 @default.
- W2903865818 cites W2756633005 @default.