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- W2903882079 endingPage "127" @default.
- W2903882079 startingPage "113" @default.
- W2903882079 abstract "Pancreatic carcinoma is usually diagnosed late when treatment options are limited and is considered a chemo-resistant malignancy. However, early stage, good performance status and specific patient subgroup are thought to have a more favorable prognosis. Search for novel molecular biomarkers, which could predict treatment resistance, represents a major opportunity, but also a challenge in further research. This review summarizes most aspects of individualized therapy of pancreatic cancer including promising biomarkers, BRCA-deficient pancreatic cancer and its etiology. It may be estimated that nearly a third of metastatic pancreatic ductal adenocarcinoma patients could benefit from treatment other than gold standard chemotherapy. Thus, other aspects of an individualized approach concerning the main factors for the choice of the best therapy for individual pancreatic cancer patient (surgery and chemotherapy), as well as the future directions (target therapy and immunotherapy), are also addressed." @default.
- W2903882079 created "2018-12-22" @default.
- W2903882079 creator A5009523282 @default.
- W2903882079 creator A5043871340 @default.
- W2903882079 creator A5058168544 @default.
- W2903882079 creator A5068588225 @default.
- W2903882079 creator A5090756163 @default.
- W2903882079 date "2019-01-01" @default.
- W2903882079 modified "2023-10-16" @default.
- W2903882079 title "Biomarkers and pathways of chemoresistance and chemosensitivity for personalized treatment of pancreatic adenocarcinoma" @default.
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