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- W2903887369 abstract "In the era of multidrug resistant (MDR) organisms, reliable efficacy testing of novel antimicrobials during developmental stages is of paramount concern prior to introduction in clinical trials. Unfortunately, interstrain variability is often underappreciated when appraising the efficacy of innovative antimicrobials as preclinical testing of a limited number of standardized strains in unvarying conditions does not account for the vastness and potential for hyperdiversity among and within microbial populations. In this review, the importance of accounting for interstrain variability's potential to impact breadth of novel drug efficacy evaluation in the early stages of drug development will be discussed. Additionally, testing under varying microenvironmental conditions that may influence drug efficacy will be discussed. Biofilm growth, the influence of polymicrobial growth, mechanisms of antimicrobial resistance, pH, anaerobic conditions, and other virulence factors are some of critical issues that require more attention and standardization during preclinical drug efficacy evaluation. Furthermore, potential solutions for addressing this issue in pre-clinical antimicrobial development are proposed via centralization of microbial characterization and drug target databases, testing of a large number of clinical strains, inclusion of mutator strains in testing and the use of growth parameter mathematical models for testing." @default.
- W2903887369 created "2018-12-22" @default.
- W2903887369 creator A5013018406 @default.
- W2903887369 creator A5058401940 @default.
- W2903887369 date "2018-12-06" @default.
- W2903887369 modified "2023-09-26" @default.
- W2903887369 title "Underscoring interstrain variability and the impact of growth conditions on associated antimicrobial susceptibilities in preclinical testing of novel antimicrobial drugs" @default.
- W2903887369 cites W1607935844 @default.
- W2903887369 cites W1864427877 @default.
- W2903887369 cites W1923407684 @default.
- W2903887369 cites W1933255153 @default.
- W2903887369 cites W1971370246 @default.
- W2903887369 cites W1972320695 @default.
- W2903887369 cites W1986622235 @default.
- W2903887369 cites W1993830991 @default.
- W2903887369 cites W1999277244 @default.
- W2903887369 cites W2002679883 @default.
- W2903887369 cites W2011541555 @default.
- W2903887369 cites W2012021753 @default.
- W2903887369 cites W2023517595 @default.
- W2903887369 cites W2028182451 @default.
- W2903887369 cites W2031445899 @default.
- W2903887369 cites W2042455145 @default.
- W2903887369 cites W2042539157 @default.
- W2903887369 cites W2045908270 @default.
- W2903887369 cites W2049388641 @default.
- W2903887369 cites W2055323879 @default.
- W2903887369 cites W2061043907 @default.
- W2903887369 cites W2061393385 @default.
- W2903887369 cites W2063095361 @default.
- W2903887369 cites W2073556554 @default.
- W2903887369 cites W2079309983 @default.
- W2903887369 cites W2084978938 @default.
- W2903887369 cites W2091356402 @default.
- W2903887369 cites W2092449637 @default.
- W2903887369 cites W2096675722 @default.
- W2903887369 cites W2099264750 @default.
- W2903887369 cites W2101996554 @default.
- W2903887369 cites W2103517471 @default.
- W2903887369 cites W2108406129 @default.
- W2903887369 cites W2111839343 @default.
- W2903887369 cites W2117709732 @default.
- W2903887369 cites W2117737432 @default.
- W2903887369 cites W2120757054 @default.
- W2903887369 cites W2125197050 @default.
- W2903887369 cites W2125808637 @default.
- W2903887369 cites W2127535305 @default.
- W2903887369 cites W2127578241 @default.
- W2903887369 cites W2129487111 @default.
- W2903887369 cites W2130440479 @default.
- W2903887369 cites W2134738688 @default.
- W2903887369 cites W2136935910 @default.
- W2903887369 cites W2139806506 @default.
- W2903887369 cites W2140039415 @default.
- W2903887369 cites W2147115456 @default.
- W2903887369 cites W2147706925 @default.
- W2903887369 cites W2149353640 @default.
- W2903887369 cites W2150480387 @default.
- W2903887369 cites W2153303237 @default.
- W2903887369 cites W2155312322 @default.
- W2903887369 cites W2156349857 @default.
- W2903887369 cites W2166808494 @default.
- W2903887369 cites W2169286099 @default.
- W2903887369 cites W2170764510 @default.
- W2903887369 cites W2173640951 @default.
- W2903887369 cites W2261913017 @default.
- W2903887369 cites W2342579072 @default.
- W2903887369 cites W2401517036 @default.
- W2903887369 cites W2407180974 @default.
- W2903887369 cites W2411078864 @default.
- W2903887369 cites W2466645477 @default.
- W2903887369 cites W2488825137 @default.
- W2903887369 cites W2527824850 @default.
- W2903887369 cites W2529409893 @default.
- W2903887369 cites W2531070838 @default.
- W2903887369 cites W2531470489 @default.
- W2903887369 cites W2551284324 @default.
- W2903887369 cites W2570714518 @default.
- W2903887369 cites W2586291022 @default.
- W2903887369 cites W2587462805 @default.
- W2903887369 cites W2683046555 @default.
- W2903887369 cites W2735299827 @default.
- W2903887369 cites W2736356388 @default.
- W2903887369 cites W2737419044 @default.
- W2903887369 cites W2744035276 @default.
- W2903887369 cites W2749795132 @default.
- W2903887369 cites W2765346922 @default.
- W2903887369 cites W2777647006 @default.
- W2903887369 cites W2786123473 @default.
- W2903887369 cites W2794657794 @default.
- W2903887369 cites W2795956641 @default.
- W2903887369 cites W2796214870 @default.
- W2903887369 cites W2800391632 @default.
- W2903887369 doi "https://doi.org/10.1080/1040841x.2018.1538934" @default.
- W2903887369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6905375" @default.
- W2903887369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30522365" @default.
- W2903887369 hasPublicationYear "2018" @default.
- W2903887369 type Work @default.