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• W2903887643 abstract "This paper presents a novel assay of biomarkers consisting of alpha-fetaprotein (AFP) via the measurements of saturation magnetization and magnetic relaxation. The biofunctionalized magnetic nanoparticles (BMNs) were anti-alpha-fetaprotein (antiAFP) coated onto dextran-coated iron oxide nanoparticles, labeled as Fe3O4-antiAFP, and then conjugated with AFP biotargets. After a complete conjugation of AFP and Fe3O4-antiAFP, the BMNs were dried for magnetic measurements. Magnetic nanoparticle images were obtained from magnetic force microscopy with details regarding the transmission electron microscopy images. Findings show that the saturation magnetization $M_{s}$ increases with a rise in the associated AFP concentration and the magnetic relaxation time $tau $ also shows a rapid increase when the concentration of AFP is lower than 0.2 ppm. Thus, we demonstrate a sensitive platform for detecting biomarkers by characterizing $M_{mathrm {s}}$ and $tau $ with a sensitivity limit of 0.03-ppm AFP. The results can be attributed to the interparticle interactions and the Neel motion of magnetic moments in BMNs." @default.
• W2903887643 created "2018-12-22" @default.
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• W2903887643 date "2019-10-15" @default.
• W2903887643 modified "2023-10-18" @default.
• W2903887643 title "Magnetic Nanoparticle Images and Assaying Biomarkers via the Magnetic Relaxation of Biofunctionalized Nanoparticles Associated With Biotargets" @default.
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• W2903887643 doi "https://doi.org/10.1109/jsen.2018.2884893" @default.
• W2903887643 hasPublicationYear "2019" @default.
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