FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903889077> ?p ?o ?g. }

• W2903889077 endingPage "8271" @default.
• W2903889077 startingPage "8259" @default.
• W2903889077 abstract "Oxidative stress is important for the calcium oxalate (CaOx)-induced kidney stone formation. Sirtuin 3 (SIRT3) plays an essential role in the amelioration of oxidative damages. This study aims to explore the effect of SIRT3 on the formation of CaOx-induced kidney stones and the underlying mechanism. SIRT3 expression in renal tissues was detected by immunohistochemistry. Apoptosis in renal tissues was examined by TUNEL staining. Crystal-cell adherence and cell apoptosis in HK-2 cells were assessed by analyzing Ca2+ concentration and by the flow cytometry analysis, respectively. Protein expression of SIRT3, nuclear factor erythroid 2-related factor (NRF2), heme oxygenase-1 (HO-1), and Bax in renal tissues or HK-2 cells was examined by Western blot analysis. Renal pathological changes and the adhesion of CaOx crystals in the kidneys were examined by hematoxylin-eosin and von Kossa staining, respectively. Human kidneys with stones showed enhanced renal apoptosis, downregulated SIRT3 expression, and upregulated NRF2/HO-1 expression, compared with the controls. Furthermore, SIRT3 overexpression inhibited the CaOx-induced promotion of crystal-cell adherence and cell apoptosis in human proximal tubular cell line HK-2 cells, which was reversed by the NRF2 knockdown. Moreover, our in vivo assay further confirmed that SIRT3 overexpression alleviated the glyoxylate administration-induced renal damage, renal apoptosis, and crystals deposition in the kidneys from the stone model mice, which was also associated with its activation of the NRF2/HO-1 pathway. Our findings support the notion that overexpression of SIRT3 may inhibit the formation of CaOx-induced kidney stones, at least in part, through regulating the NRF2/HO-1 signaling pathway." @default.
• W2903889077 created "2018-12-22" @default.
• W2903889077 creator A5024063242 @default.
• W2903889077 creator A5025160212 @default.
• W2903889077 creator A5034058657 @default.
• W2903889077 creator A5039519985 @default.
• W2903889077 creator A5055033429 @default.
• W2903889077 creator A5066716873 @default.
• W2903889077 creator A5083417334 @default.
• W2903889077 date "2018-12-12" @default.
• W2903889077 modified "2023-09-26" @default.
• W2903889077 title "SIRT3 inhibited the formation of calcium oxalate‐induced kidney stones through regulating NRF2/HO‐1 signaling pathway" @default.
• W2903889077 cites W1501561366 @default.
• W2903889077 cites W1762535185 @default.
• W2903889077 cites W1965431364 @default.
• W2903889077 cites W1965976089 @default.
• W2903889077 cites W1970009760 @default.
• W2903889077 cites W1989785500 @default.
• W2903889077 cites W2013688634 @default.
• W2903889077 cites W2018038176 @default.
• W2903889077 cites W2031004071 @default.
• W2903889077 cites W2043137911 @default.
• W2903889077 cites W2044155459 @default.
• W2903889077 cites W2063229731 @default.
• W2903889077 cites W2072250666 @default.
• W2903889077 cites W2084708023 @default.
• W2903889077 cites W2087439645 @default.
• W2903889077 cites W2101580126 @default.
• W2903889077 cites W2109163960 @default.
• W2903889077 cites W2283410229 @default.
• W2903889077 cites W2343492981 @default.
• W2903889077 cites W2407882320 @default.
• W2903889077 cites W2474043843 @default.
• W2903889077 cites W2508124992 @default.
• W2903889077 cites W2566024396 @default.
• W2903889077 cites W2580712761 @default.
• W2903889077 cites W2581822489 @default.
• W2903889077 cites W2593979922 @default.
• W2903889077 cites W2752569292 @default.
• W2903889077 cites W2769545777 @default.
• W2903889077 cites W2804946677 @default.
• W2903889077 cites W2806892533 @default.
• W2903889077 doi "https://doi.org/10.1002/jcb.28109" @default.
• W2903889077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30548662" @default.
• W2903889077 hasPublicationYear "2018" @default.
• W2903889077 type Work @default.
• W2903889077 sameAs 2903889077 @default.
• W2903889077 citedByCount "16" @default.
• W2903889077 countsByYear W29038890772019 @default.
• W2903889077 countsByYear W29038890772020 @default.
• W2903889077 countsByYear W29038890772021 @default.
• W2903889077 countsByYear W29038890772022 @default.
• W2903889077 countsByYear W29038890772023 @default.
• W2903889077 crossrefType "journal-article" @default.
• W2903889077 hasAuthorship W2903889077A5024063242 @default.
• W2903889077 hasAuthorship W2903889077A5025160212 @default.
• W2903889077 hasAuthorship W2903889077A5034058657 @default.
• W2903889077 hasAuthorship W2903889077A5039519985 @default.
• W2903889077 hasAuthorship W2903889077A5055033429 @default.
• W2903889077 hasAuthorship W2903889077A5066716873 @default.
• W2903889077 hasAuthorship W2903889077A5083417334 @default.
• W2903889077 hasConcept C104317684 @default.
• W2903889077 hasConcept C119157956 @default.
• W2903889077 hasConcept C134018914 @default.
• W2903889077 hasConcept C138488276 @default.
• W2903889077 hasConcept C153911025 @default.
• W2903889077 hasConcept C185592680 @default.
• W2903889077 hasConcept C190283241 @default.
• W2903889077 hasConcept C2776151105 @default.
• W2903889077 hasConcept C2776179656 @default.
• W2903889077 hasConcept C2780091579 @default.
• W2903889077 hasConcept C2780561631 @default.
• W2903889077 hasConcept C55493867 @default.
• W2903889077 hasConcept C77411442 @default.
• W2903889077 hasConcept C86803240 @default.
• W2903889077 hasConcept C95444343 @default.
• W2903889077 hasConceptScore W2903889077C104317684 @default.
• W2903889077 hasConceptScore W2903889077C119157956 @default.
• W2903889077 hasConceptScore W2903889077C134018914 @default.
• W2903889077 hasConceptScore W2903889077C138488276 @default.
• W2903889077 hasConceptScore W2903889077C153911025 @default.
• W2903889077 hasConceptScore W2903889077C185592680 @default.
• W2903889077 hasConceptScore W2903889077C190283241 @default.
• W2903889077 hasConceptScore W2903889077C2776151105 @default.
• W2903889077 hasConceptScore W2903889077C2776179656 @default.
• W2903889077 hasConceptScore W2903889077C2780091579 @default.
• W2903889077 hasConceptScore W2903889077C2780561631 @default.
• W2903889077 hasConceptScore W2903889077C55493867 @default.
• W2903889077 hasConceptScore W2903889077C77411442 @default.
• W2903889077 hasConceptScore W2903889077C86803240 @default.
• W2903889077 hasConceptScore W2903889077C95444343 @default.
• W2903889077 hasIssue "5" @default.
• W2903889077 hasLocation W29038890771 @default.
• W2903889077 hasLocation W29038890772 @default.
• W2903889077 hasOpenAccess W2903889077 @default.
• W2903889077 hasPrimaryLocation W29038890771 @default.
• W2903889077 hasRelatedWork W1975693372 @default.
• W2903889077 hasRelatedWork W2327960937 @default.

• next