FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2903889319> ?p ?o ?g. }

• W2903889319 endingPage "647" @default.
• W2903889319 startingPage "634" @default.
• W2903889319 abstract "Recent studies have shown the efficacy of autologous haematopoietic stem cell transplantation [HSCT] in severely refractory Crohn’s disease [CD] patients. HSCT is thought to eliminate auto-reactive cells; however, no specific studies of immune reconstitution in CD patients are available. We followed a group of CD patients [n = 18] receiving autologous HSCT, with 50% of them achieving endoscopic drug-free remission. To elucidate the mechanisms driving efficacy, we monitored changes after HSCT in blood and intestine immune-cell composition. CD patients [n = 22] receiving anti-tumour necrosis factor [TNF]-α were included for comparison. Severe immune ablation followed by HSCT induced dramatic changes in both peripheral blood T and B cells in all patients regardless of the efficacy of the treatment. Endoscopic remission at week 52 following HSCT was associated with significant intestinal transcriptional changes. A comparison of the remission signature with that of anti-TNFα identified both common and unique genes in the HSCT-induced response. Based on deconvolution analysis of intestinal biopsy transcriptome data, we show that response to HSCT, but not to anti-TNFα, is associated with an expansion of naïve B-cells, as seen in blood, and a decrease in the memory resting T-cell content. As expected, endoscopic remission, in response to both HSCT and anti-TNFα, led to a significant reduction in intestinal neutrophil and M1 macrophage content. Peripheral blood immune remodelling after HSCT does not predict efficacy. In contrast, a profound intestinal T-cell depletion that is maintained long after transplant is associated with mucosal healing following HSCT, but not anti-TNFα." @default.
• W2903889319 created "2018-12-22" @default.
• W2903889319 creator A5001406662 @default.
• W2903889319 creator A5006827357 @default.
• W2903889319 creator A5008552726 @default.
• W2903889319 creator A5010303736 @default.
• W2903889319 creator A5015665559 @default.
• W2903889319 creator A5016235381 @default.
• W2903889319 creator A5027265955 @default.
• W2903889319 creator A5039924630 @default.
• W2903889319 creator A5040354010 @default.
• W2903889319 creator A5046775079 @default.
• W2903889319 creator A5046862803 @default.
• W2903889319 creator A5048807291 @default.
• W2903889319 creator A5050738791 @default.
• W2903889319 creator A5066635109 @default.
• W2903889319 creator A5076935487 @default.
• W2903889319 creator A5080119173 @default.
• W2903889319 creator A5083030179 @default.
• W2903889319 creator A5084515363 @default.
• W2903889319 date "2018-12-06" @default.
• W2903889319 modified "2023-10-15" @default.
• W2903889319 title "Differences in Peripheral and Tissue Immune Cell Populations Following Haematopoietic Stem Cell Transplantation in Crohn’s Disease Patients" @default.
• W2903889319 cites W118686632 @default.
• W2903889319 cites W1481612531 @default.
• W2903889319 cites W1545946482 @default.
• W2903889319 cites W1573380982 @default.
• W2903889319 cites W1922746363 @default.
• W2903889319 cites W1969584481 @default.
• W2903889319 cites W1970860090 @default.
• W2903889319 cites W1985987855 @default.
• W2903889319 cites W1992683442 @default.
• W2903889319 cites W2021047585 @default.
• W2903889319 cites W2041288820 @default.
• W2903889319 cites W2046234296 @default.
• W2903889319 cites W2048175139 @default.
• W2903889319 cites W2049216452 @default.
• W2903889319 cites W2067112635 @default.
• W2903889319 cites W2077531651 @default.
• W2903889319 cites W2078578609 @default.
• W2903889319 cites W2078843571 @default.
• W2903889319 cites W2107663968 @default.
• W2903889319 cites W2119693087 @default.
• W2903889319 cites W2125701590 @default.
• W2903889319 cites W2128735729 @default.
• W2903889319 cites W2131727303 @default.
• W2903889319 cites W2133672526 @default.
• W2903889319 cites W2168654564 @default.
• W2903889319 cites W2201119837 @default.
• W2903889319 cites W2202486845 @default.
• W2903889319 cites W2290604176 @default.
• W2903889319 cites W2411597002 @default.
• W2903889319 cites W2585938789 @default.
• W2903889319 cites W2598029054 @default.
• W2903889319 cites W2604317799 @default.
• W2903889319 cites W2606558706 @default.
• W2903889319 cites W2608128228 @default.
• W2903889319 cites W2796319877 @default.
• W2903889319 cites W4233817719 @default.
• W2903889319 doi "https://doi.org/10.1093/ecco-jcc/jjy203" @default.
• W2903889319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6486491" @default.
• W2903889319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30521002" @default.
• W2903889319 hasPublicationYear "2018" @default.
• W2903889319 type Work @default.
• W2903889319 sameAs 2903889319 @default.
• W2903889319 citedByCount "14" @default.
• W2903889319 countsByYear W29038893192020 @default.
• W2903889319 countsByYear W29038893192021 @default.
• W2903889319 countsByYear W29038893192022 @default.
• W2903889319 countsByYear W29038893192023 @default.
• W2903889319 crossrefType "journal-article" @default.
• W2903889319 hasAuthorship W2903889319A5001406662 @default.
• W2903889319 hasAuthorship W2903889319A5006827357 @default.
• W2903889319 hasAuthorship W2903889319A5008552726 @default.
• W2903889319 hasAuthorship W2903889319A5010303736 @default.
• W2903889319 hasAuthorship W2903889319A5015665559 @default.
• W2903889319 hasAuthorship W2903889319A5016235381 @default.
• W2903889319 hasAuthorship W2903889319A5027265955 @default.
• W2903889319 hasAuthorship W2903889319A5039924630 @default.
• W2903889319 hasAuthorship W2903889319A5040354010 @default.
• W2903889319 hasAuthorship W2903889319A5046775079 @default.
• W2903889319 hasAuthorship W2903889319A5046862803 @default.
• W2903889319 hasAuthorship W2903889319A5048807291 @default.
• W2903889319 hasAuthorship W2903889319A5050738791 @default.
• W2903889319 hasAuthorship W2903889319A5066635109 @default.
• W2903889319 hasAuthorship W2903889319A5076935487 @default.
• W2903889319 hasAuthorship W2903889319A5080119173 @default.
• W2903889319 hasAuthorship W2903889319A5083030179 @default.
• W2903889319 hasAuthorship W2903889319A5084515363 @default.
• W2903889319 hasBestOaLocation W29038893191 @default.
• W2903889319 hasConcept C109159458 @default.
• W2903889319 hasConcept C126322002 @default.
• W2903889319 hasConcept C17991360 @default.
• W2903889319 hasConcept C203014093 @default.
• W2903889319 hasConcept C2777408962 @default.
• W2903889319 hasConcept C2779972918 @default.
• W2903889319 hasConcept C28328180 @default.
• W2903889319 hasConcept C2911091166 @default.

• next