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- W2903894274 abstract "Aim: Differential pulse polarography was used for the concurrent analysis of the coadministered dantrolene (DAN) and indomethacin (IND) in plasma. Materials & methods: DAN and IND, Hanging mercury drop electrode and Britton–Robinson buffer at pH 5 were used. In plasma, cathodic reduction of DAN nitro group and its active metabolite at -0.2 V was done. IND was analyzed after carbonyl group reduction at -1.1 V. Results: Drugs determination in rat plasma with good recoveries and low limit of quantitation was done. Application to trace analysis of drugs in rat plasma was done with C max and T max determination. Conclusion: This technique shows high sensitivity, simplicity and low cost. The method is US FDA validated and it is applicable to human level." @default.
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- W2903894274 date "2019-01-01" @default.
- W2903894274 modified "2023-09-27" @default.
- W2903894274 title "Voltammetric analysis of dantrolene and its active metabolite with indomethacin in rat plasma" @default.
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- W2903894274 doi "https://doi.org/10.4155/bio-2018-0165" @default.
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