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- W2903910188 endingPage "301" @default.
- W2903910188 startingPage "293" @default.
- W2903910188 abstract "Osteoporosis is characterized by low bone mass, poor bone microarchitecture, and deteriorated bone material properties, which lead jointly to a higher bone fragility. These abnormalities are highly influenced by modifications of bone turnover. Bone turnover is characterized by formation of new bone by osteoblasts and resorption of old bone by osteoclasts. These two opposite activities are tightly coupled in time and space at the level of basic multicellular unit (BMU). During bone remodeling (after growth arrest and during aging), bone formation is preceded by bone resorption. During bone resorption, dissolution of bone mineral and catabolism of bone matrix by osteoclasts results in the formation of a resorptive cavity and the release of bone matrix components. Then, during bone formation, osteoblasts synthesize bone matrix, which fills in the resorption cavity and undergoes mineralization." @default.
- W2903910188 created "2018-12-22" @default.
- W2903910188 creator A5002843087 @default.
- W2903910188 creator A5021940540 @default.
- W2903910188 creator A5064307236 @default.
- W2903910188 date "2018-09-28" @default.
- W2903910188 modified "2023-09-27" @default.
- W2903910188 title "Biochemical Markers of Bone Turnover in Osteoporosis" @default.
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